Single-incision sleeve plus bypass shows short-term safety and metabolic improvement in 3 patients with obesity and T2DMSILSG-JJB Procedure Shows Promise for Weight Loss and Diabetes

BackgroundSingle-incision laparoscopic sleeve gastrectomy plus jejunojejunal bypass (SILSG-JJB) is a novel modification of metabolic bariatric surgery. Clinical experience with this approach remains limited, particularly in patients with severe obesity and type 2 diabetes mellitus (T2DM).Case presentationWe present a case series of three female patients aged 23–30 years with severe obesity complicated by metabolic syndrome and T2DM who underwent SILSG-JJB. Perioperative course and short-term metabolic outcomes were recorded. All procedures were successfully completed through a single incision without additional port placement or conversion to open surgery. No major intraoperative or perioperative complications occurred. Postoperative recovery was uneventful, and all patients were discharged on postoperative day 3. During the short-term follow-up period, satisfactory weight loss and improvement in fasting blood glucose levels were observed, with no procedure-related adverse events or postoperative malnutrition.ConclusionsThis case series demonstrates the technical feasibility and short-term safety of SILSG-JJB in selected patients with severe obesity and T2DM. Short-term follow-up indicated that SILSG-JJB could achieve significant weight reduction and improve metabolic comorbidity-related parameters, including those associated with T2DM. However, its long-term efficacy and safety in obese patients with T2DM and other metabolic complications remain to be further investigated. Further multicenter studies with larger cohorts and longer follow-up durations are required to determine its long-term efficacy, safety, and generalizability.