Gut microbiota modulation offers insights for heat stroke prevention and treatment in clinical practice
Gut bacteria may help prevent heat stroke, but human proof is limited
This narrative review examines gut microbiota modulation using probiotics for heat stroke. The authors note that much evidence comes from pr…
A review suggests gut microbiota changes might help prevent heat stroke, yet most evidence comes from animal experiments rather than human t…
Neurostimulation therapies improve swallowing function in acutely ill patients with a standardized mean difference of -0.74
Neurostimulation Therapies Improve Swallowing in Critically Ill Patients
This systematic review and network meta-analysis evaluated neurostimulation therapies for dysphagia in 2198 acutely and critically ill patie…
A review of 20 studies found that neurostimulation therapies can significantly improve swallowing function in critically ill patients with d…
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest
New trial shows bone and vein access methods give similar survival rates for heart stop patients
This randomized clinical trial enrolled 1479 adults with non-traumatic out-of-hospital cardiac arrest to compare initial intraosseous vascul…
Doctors compared putting medicine in a bone versus a vein for adults whose hearts stopped outside a hospital. The study found no important d…
Dengue vaccines lower viremia rates and hemorrhagic fever risk compared to placebo in a meta-analysis of 175434 participants
Dengue vaccines show lower rates of infection and severe fever compared to placebo
This meta-analysis evaluated dengue vaccines versus placebo across 175434 participants. The analysis found lower rates of viremia and hemorr…
A large analysis of dengue vaccines shows they lower the risk of infection and severe fever, with antibody production also increasing.
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
Recombinant human interleukin-7 boosts white blood cells but does not save lives in sepsis or COVID-19
A meta-analysis shows recombinant IL-7 boosts lymphocytes in sepsis and COVID-19, but only reduces secondary infections in COVID-19.
A new analysis shows this drug raises low white blood cell counts in sepsis and COVID-19 but does not lower death risk or improve survival.
ECMO cannulation by intensivists shows 2% per cannula and 5% per patient complication rates in a meta-analysis of 12 studies
Intensivists Can Safely Perform ECMO Cannulation, Review Finds
This systematic review and meta-analysis evaluated complication rates associated with ECMO cannulation performed by intensivists across 12 s…
A review of 12 studies finds intensivists can safely place ECMO lines, with low complication rates.
Carbon-plated shoes show minimal biomechanical impact in healthy adults
Carbon-plated shoes show little change in leg mechanics
A meta-analysis of fifteen studies found carbon-plated running shoes did not consistently alter leg stiffness or joint power compared to non…
A review of 15 studies finds carbon-plated running shoes do not consistently change leg stiffness or joint power compared to regular shoes.
Network meta-analysis ranks blood purification strategies for severe acute pancreatitis
Blood Purification May Help Severe Pancreatitis Scores But Not Mortality
A network meta-analysis of 3,707 patients found hemoperfusion plus continuous renal replacement therapy most effective for improving APACHE …
A network meta-analysis of 3,707 patients found specific blood purification methods improved organ function scores but did not lower death r…
ERAS protocols may reduce opioid use and shorten stays for patients undergoing orthognathic surgery
ERAS protocols show promise for orthognathic surgery recovery
This narrative review examines the application of Enhanced Recovery After Surgery (ERAS) protocols in orthognathic surgery. The authors synt…
Enhanced Recovery After Surgery protocols may reduce opioid use and shorten hospital stays for patients undergoing jaw surgery.
Ectopic thyroid carcinoma survival worsens with age over 50 years and chest or abdominal tumor location
Ectopic thyroid cancer survival linked to age and tumor location
This systematic review analyzed 506 patients with ectopic thyroid carcinoma to evaluate treatment strategies. Overall survival was worse for…
A review of 506 patients found older age and chest or abdominal tumors lower survival chances. Surgery type did not significantly change rec…
Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism
New trial shows ultrasound-guided clot-busting drugs help some patients with serious lung clots recover faster and safely
This randomized controlled trial evaluated ultrasound-facilitated, catheter-directed fibrinolysis with alteplase plus anticoagulation versus…
A large study found that using ultrasound to guide clot-busting medicine helped patients with serious lung clots avoid bad outcomes. The tre…