Dengue vaccines lower viremia rates and hemorrhagic fever risk compared to placebo in a meta-analysis of 175434 participants
Dengue vaccines show lower rates of infection and severe fever compared to placebo
This meta-analysis evaluated dengue vaccines versus placebo across 175434 participants. The analysis found lower rates of viremia and hemorr…
A large analysis of dengue vaccines shows they lower the risk of infection and severe fever, with antibody production also increasing.
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Interleukin-7 therapy improves lymphocyte counts in sepsis and COVID-19 patients
Recombinant human interleukin-7 boosts white blood cells but does not save lives in sepsis or COVID-19
A meta-analysis shows recombinant IL-7 boosts lymphocytes in sepsis and COVID-19, but only reduces secondary infections in COVID-19.
A new analysis shows this drug raises low white blood cell counts in sepsis and COVID-19 but does not lower death risk or improve survival.
ECMO cannulation by intensivists shows 2% per cannula and 5% per patient complication rates in a meta-analysis of 12 studies
Intensivists Can Safely Perform ECMO Cannulation, Review Finds
This systematic review and meta-analysis evaluated complication rates associated with ECMO cannulation performed by intensivists across 12 s…
A review of 12 studies finds intensivists can safely place ECMO lines, with low complication rates.
Network meta-analysis ranks blood purification strategies for severe acute pancreatitis
Blood Purification May Help Severe Pancreatitis Scores But Not Mortality
A network meta-analysis of 3,707 patients found hemoperfusion plus continuous renal replacement therapy most effective for improving APACHE …
A network meta-analysis of 3,707 patients found specific blood purification methods improved organ function scores but did not lower death r…
Carbon-plated shoes show minimal biomechanical impact in healthy adults
Carbon-plated shoes show little change in leg mechanics
A meta-analysis of fifteen studies found carbon-plated running shoes did not consistently alter leg stiffness or joint power compared to non…
A review of 15 studies finds carbon-plated running shoes do not consistently change leg stiffness or joint power compared to regular shoes.
ERAS protocols may reduce opioid use and shorten stays for patients undergoing orthognathic surgery
ERAS protocols show promise for orthognathic surgery recovery
This narrative review examines the application of Enhanced Recovery After Surgery (ERAS) protocols in orthognathic surgery. The authors synt…
Enhanced Recovery After Surgery protocols may reduce opioid use and shorten hospital stays for patients undergoing jaw surgery.
Ectopic thyroid carcinoma survival worsens with age over 50 years and chest or abdominal tumor location
Ectopic thyroid cancer survival linked to age and tumor location
This systematic review analyzed 506 patients with ectopic thyroid carcinoma to evaluate treatment strategies. Overall survival was worse for…
A review of 506 patients found older age and chest or abdominal tumors lower survival chances. Surgery type did not significantly change rec…
Ultrasound-facilitated catheter-directed alteplase reduces early recurrence in intermediate-risk pulmonary embolism
New trial shows ultrasound-guided clot-busting drugs help some patients with serious lung clots recover faster and safely
This randomized controlled trial evaluated ultrasound-facilitated, catheter-directed fibrinolysis with alteplase plus anticoagulation versus…
A large study found that using ultrasound to guide clot-busting medicine helped patients with serious lung clots avoid bad outcomes. The tre…
Early Physical Interventions Reduce ICU-Acquired Weakness Risk
Early exercise in the ICU may prevent muscle weakness
A network meta-analysis of 63 RCTs finds that early mobilisation and neuromuscular electrical stimulation significantly reduce ICU-acquired …
Starting physical therapy early in the ICU could cut the risk of severe muscle weakness by a large amount, a new analysis suggests.
High mortality rates observed in community-acquired pneumonia patients within intensive care units across low- and middle-income regions
Community-acquired pneumonia kills one in three ICU patients in low- and middle-income countries
A systematic review and meta-analysis of 48,707 patients reveals stark mortality risks for community-acquired pneumonia in resource-limited …
A massive review shows that one in three patients with pneumonia admitted to ICUs in low- and middle-income countries dies within a month.
Evidence summary on glycemic variability management in ICU patients with cerebral infarction
ICU Guidelines Suggest Managing Blood Sugar Swings During Feeding
This evidence summary synthesizes 18 documents on glycemic variability management during enteral nutrition for adult ICU patients with cereb…
Guidelines advise managing blood sugar swings in ICU patients receiving tube feeding, noting that individual adjustments depend on local res…