Plasma biomarker models show high discrimination but NPV decline in cross-cohort Alzheimer's validation
Can a blood test predict Alzheimer's in new patients? The answer depends on where the test was developed.
A cohort study in ADNI and A4 cohorts (n=885 and n=822) found that machine learning models using plasma biomarkers achieved ROC AUCs of 0.91…
A promising Alzheimer's blood test loses its accuracy when used on a different patient group, raising concerns about false reassurance in re…
Review synthesizes electroacupuncture effects on cerebral ischemia-reperfusion injury mechanisms
Could electroacupuncture protect the brain from injury, and what does the current review tell us?
This narrative review examines the role of electroacupuncture in addressing cerebral ischemia-reperfusion injury. The authors synthesize evi…
Electroacupuncture may shield the brain from stroke-related damage by reducing inflammation and protecting cells, though real-world safety a…
Systematic review examines yoga effects on brain structure and function in healthy participants across 23 studies.
Could yoga change your brain, and what does the latest research actually tell us?
This systematic review synthesizes findings from 23 international peer-reviewed neuroimaging studies involving healthy participants to asses…
Yoga may change your brain's structure and function, but mixed study results mean we don't know exactly which parts of the practice help yet…
Single-center Phase 1 RCT assesses ALC05 injection safety in unilateral mesial temporal lobe epilepsy patients.
New Cell Therapy Could Stop Seizures Safely
This single-center Phase 1 randomized controlled trial evaluated the safety of a single intracranial injection of ALC05, iPSC-derived GABAer…
A new cell therapy aims to stop seizures safely by injecting living cells into the brain, offering a gentler alternative to risky surgery fo…
Review explores PARP-1 and α-synuclein interactions in Parkinson's disease neuropathology
Could a protein switch drive the nerve damage seen in Parkinson's disease?
This narrative review synthesizes evidence on the interplay between PARP-1 activation and α-synuclein in Parkinson's disease, highlighting r…
An overactive protein switch in brain cells triggers the clumps and stress that drive nerve damage in Parkinson's disease.
qMPM metrics show microstructural alterations in white matter hyperintensities and perilesional tissue
New brain scan metrics show subtle changes in white matter linked to cognitive performance in older adults.
A cohort study of 245 participants from the BeLOVE study found that quantitative Multi-Parametric Mapping (qMPM) metrics detected significan…
New brain scan metrics detect subtle white matter changes linked to cognitive performance in older adults, offering early insight into brain…
Systemic inflammatory indices are elevated in pediatric drug-resistant epilepsy versus self-limited epilepsy with centrotemporal spikes.
Are inflammation markers higher in children with hard-to-treat epilepsy than those with self-limited cases?
This real-world cohort study of 140 pediatric patients compared systemic inflammatory indices (NLR, SII, CRP) between those with drug-resist…
Children with hard-to-treat epilepsy show higher blood inflammation markers than those with self-limited cases, though the exact link to bra…
COVID-19 and vitamin D status linked to IL-6 and IL-18 levels in children
Low Vitamin D Linked to Higher Inflammation in Kids
This cohort study of 170 children aged 1–17 years with PCR-confirmed SARS-CoV-2 infection measured serum IL-6 and IL-18 in relation to vitam…
Low vitamin D might make inflammation worse in children with COVID-19, but doctors need more proof before changing treatment plans.
Overweight or obesity linked to lower odds of excellent stroke outcome, but higher triglycerides may improve recovery
Extra Weight Hurts Stroke Recovery, Even If Tests Suggested Otherwise
A retrospective cohort study of 571 consecutive acute ischemic stroke patients found that overweight or obesity was independently associated…
Carrying extra weight slows stroke recovery even when blood fat levels are normal, overturning the long-held belief that heavier patients fa…
Patient factors predict post-stroke fatigue at four weeks in a retrospective cohort.
New Tool Spots Stroke Survivors Most Likely to Feel Crushing Fatigue
This retrospective cohort study evaluated 846 stroke patients hospitalized at two Chinese medical centers. Researchers identified independen…
A new scoring chart helps doctors spot stroke survivors at high risk for deep, lingering fatigue weeks before it takes hold.
Retrospective cross-sectional study characterizes arachnoiditis patient presentation and treatment responses in 1105 participants.
Back Pain That Won't Go Away
This retrospective cross-sectional study characterized clinical presentation, comorbidities, and treatments in 1105 participants with physic…
A massive online community of chronic pain patients helped researchers finally map the symptoms and treatments for the often missed conditio…
High school football players show neurophysiological changes linked to head impact exposure.
Does head impact exposure in high school football change brain activity patterns?
An observational study of 91 high school football players found that head impact exposure, including concussive and non-concussive events, w…
Repeated head hits in high school football slow brain activity in ways linked to specific genes and chemicals, even without concussions.