HER2, PD-L1, MSI/MMR, and CLDN18.2 biomarkers may guide treatment selection in gastric cancer conversion therapy
Biomarkers help doctors choose better treatments for gastric cancer
This narrative review explores the clinical utility of HER2, PD-L1, MSI/MMR, and CLDN18.2 biomarkers in patients with gastric cancer undergo…
New markers like HER2 and CLDN18.2 help doctors identify which gastric cancer patients might respond best to specific therapies before surge…
MULTIPL biomarker identifies patients with significantly longer overall survival on gemcitabine plus nab-paclitaxel
Trial Shows Biomarker Helps Identify Best Treatment for Pancreatic Cancer
This randomized Phase II trial and training cohort evaluated the MULTIPL biomarker in 160 and 268 patients with metastatic pancreatic ductal…
A new biomarker tool may help doctors choose the most effective chemotherapy for patients with metastatic pancreatic cancer.
Zika virus oncolytic therapy provides significant pooled survival benefit in preclinical glioblastoma models
Zika Virus Based Therapy Shows Potential for Glioblastoma Treatment
This systematic review and meta-analysis of 24 experimental clusters in preclinical in vivo studies found a significant pooled survival bene…
A review of early laboratory studies suggests that a Zika virus based therapy may improve survival in glioblastoma cases.
Ranibizumab port delivery system shows noninferior BCVA gains and low supplemental treatment requirements in diabetic retinopathy
Ranibizumab port delivery system shows promise for diabetic eye conditions
This meta-analysis evaluates the ranibizumab port delivery system (PDS) for patients with diabetic retinopathy and diabetic macular edema. T…
A new delivery system for ranibizumab shows consistent results for patients with diabetic retinopathy and macular edema.
Paclitaxel and Cisplatin Combination Improves Outcomes in Locoregionally Advanced Nasopharyngeal Carcinoma
Trial shows TPC chemotherapy improves survival for nasopharyngeal carcinoma
A randomized trial demonstrates that TPC induction chemotherapy significantly improves failure-free survival for patients with high-risk nas…
A new clinical trial found that a specific three-drug induction chemotherapy may improve survival rates for patients with high-risk nasophar…
Radiomic Features Demonstrate High Diagnostic Accuracy for Predicting Ki-67 Expression in Hepatocellular Carcinoma
Radiomic Features Help Predict Ki-67 Levels in Liver Cancer
Meta-analysis of 1,708 patients shows radiomic features provide high sensitivity and specificity for predicting Ki-67 expression in HCC.
New data shows that radiomic features can accurately predict Ki-67 expression levels in patients with hepatocellular carcinoma.
ICI-based combinations show measurable but heterogeneous activity in platinum-resistant ovarian cancer
Combination therapy shows mixed results for advanced ovarian cancer
This systematic review and meta-analysis of ICI-based combination therapies in platinum-resistant ovarian cancer found an ORR of 21.9% and a…
New data reveals that while some patients with resistant ovarian cancer see stable disease, the effectiveness of certain drug combinations v…
Percutaneous hepatic perfusion improves response rates and progression-free survival in metastatic uveal melanoma
Liver perfusion shows better response rates for metastatic uveal melanoma
This meta-analysis of patients with metastatic uveal melanoma found that percutaneous hepatic perfusion (PHP) is associated with higher over…
A new analysis suggests liver perfusion may improve response and progression-free time for patients with a rare form of eye cancer.
KRAS G12C inhibitors may remodel immunosuppressive tumor microenvironments into immunostimulatory states in KRAS-mutant tumors
Targeted Drugs May Help Change Immune Environment in KRAS Tumors
This mini-review examines the impact of KRAS mutations and G12C inhibitors on the tumor immune microenvironment across PDAC, CRC, and LAC. T…
New research suggests that specific drugs targeting KRAS mutations may help reshape the immune environment around certain types of cancer.
Nicotine electronic cigarettes increase quit rates compared to nicotine replacement therapy and behavioral support
Nicotine electronic cigarettes show higher quit rates than traditional methods
This systematic review of 80 RCTs involving 29,861 participants found that nicotine electronic cigarettes (EC) significantly increased quit …
New data shows people using nicotine-containing electronic cigarettes are more likely to quit smoking compared to those using standard repla…
Deep Learning algorithms demonstrate potential for diagnosing oral potentially malignant disorders and squamous cell carcinoma
Artificial Intelligence Shows Potential for Detecting Oral Cancer
This meta-analysis evaluated the diagnostic accuracy of deep learning models using white light digital photographs to identify oral malignan…
New research shows that deep learning tools can help identify oral cancer and precancerous conditions using simple digital photos.
iPSC-derived CAR-NK extracellular vesicles represent a translational hypothesis for non-small cell lung cancer
New Research Explores Using Nanoscale Vesicles for Lung Cancer
This narrative review explores the use of iPSC-derived CAR-NK extracellular vesicles (EVs/sEVs) as an investigational platform for non-small…
Scientists are exploring how tiny vesicles from engineered cells might offer a safer way to deliver cancer treatments directly to lung tumor…