First-line osimertinib shows high response rates in EGFR-mutated NSCLC with active brain metastases
Untreated Brain Metastases Respond Well to Osimertinib
This single-arm phase II trial evaluated first-line osimertinib in 100 patients with EGFR-mutated non-small cell lung cancer, including thos…
Osimertinib, a lung cancer drug, effectively treats untreated brain metastases, with an 81.8% response rate for measurable brain spots in a …
Virtual wards and hospital at home show no survival or readmission benefit for ECOPD patients compared to hospital admission
Home Hospital Care for COPD Flares Shows No Clear Win
This systematic review and meta-analysis evaluated virtual wards (VW) and hospital at home (HaH) versus hospital admission for adults with e…
Sending COPD patients home with remote monitoring did not reduce deaths or readmissions, but it also did not cause harm.
Non-cirrhotic portal fibrosis identified in 32.6% of pre-cirrhotic primary biliary cholangitis patients in a retrospective analysis
Hidden Liver Damage Found in Early PBC
This retrospective analysis examined 92 biopsy-proven pre-cirrhotic primary biliary cholangitis (PBC) patients to characterize non-cirrhotic…
Many people with primary biliary cholangitis develop hidden liver damage called non-cirrhotic portal fibrosis before permanent scarring begi…
Phase Ib/II trial of nintedanib plus nivolumab in pretreated NSCLC adenocarcinoma shows 25% 6-month PFS rate
New Drug Combo Helps Some Lung Cancer Patients Live Longer
A single-arm, open-label phase Ib/II trial in 52 patients with pretreated stage IIIB/IV NSCLC adenocarcinoma found a 6-month progression-fre…
A new drug pair safely extends life for some advanced lung cancer patients who previously tried immunotherapy or have high PD-L1 markers.
EMG measurement is feasible in primary care for stable mild to moderate COPD patients
A Simple Test Can Now Track Your COPD’s Hidden Strain
This randomized controlled trial assessed the feasibility of parasternal electromyography (EMG) in 40 participants with stable mild to moder…
A new, easy-to-use sensor can detect the extra work your breathing muscles are doing because of COPD, giving doctors a clearer picture of yo…
Age-period-cohort analysis shows declining bacteriologically confirmed pulmonary tuberculosis incidence in Hunan Province, China, 2009–2023
For decades, the fight against tuberculosis (TB) has followed a familiar script. But new data reveals the story is changing. The faces of those most vulnerable are shifting in surprising ways
This review analyzed population-based surveillance data from Hunan Province, China, from 2009 to 2023 to assess trends in bacteriologically …
Tuberculosis risk now peaks in young adults and the elderly, with the sharpest rise in the oldest age group, signaling a shift in who needs …
Meta-analysis finds inhaled corticosteroids associated with reduced cardiovascular mortality in COPD patients
A Common COPD Medicine May Also Protect Your Heart
A systematic review and meta-analysis of 74,004 COPD patients found inhaled corticosteroid-containing formulations were associated with redu…
For people with COPD, a medication they already use to breathe easier might also offer a hidden layer of protection for their heart.
Meta-analysis finds limited evidence for CPET variables in COPD mortality prediction
CPET variables linked to COPD mortality but routine use not yet supported
A systematic review and meta-analysis of 16 studies in COPD patients examined cardiopulmonary exercise testing (CPET) variables for predicti…
Peak oxygen uptake and ventilatory efficiency from exercise tests predict death in chronic obstructive pulmonary disease, though routine use…
Monthly phone counseling increased willingness to set lifestyle goals in patients with chronic obstructive pulmonary disease
Most COPD patients willing to set lifestyle goals after counseling
This randomized controlled trial evaluated monthly phone calls offering lifestyle counseling on diet and physical activity using motivationa…
Most COPD patients are willing to set lifestyle goals after counseling, with 71% focusing on physical activity and adjusting targets as need…
Higher Red Cell Distribution Width to Albumin Ratio (RAR) associated with increased mortality in pulmonary sepsis
High RAR linked to higher death risk in pulmonary sepsis patients
A retrospective dual-cohort study of 6,065 patients with pulmonary sepsis found that a higher Red Cell Distribution Width to Albumin Ratio (…
A high Red Cell Distribution Width to Albumin Ratio score predicts a significantly greater chance of dying within 28 days for patients with …
Retrospective study links IVIG plus azithromycin to higher response rate in pediatric Mycoplasma pneumoniae pneumonia
When a Child's Pneumonia Won't Clear, This Add-On May Help
A single-center retrospective cohort of 140 children with Mycoplasma pneumoniae pneumonia found that adding intravenous immunoglobulin (IVIG…
Adding donor antibodies to standard antibiotics helped 97% of children with stubborn pneumonia recover, compared to 84% on antibiotics alone…
In vitro amikacin resistance linked to kanamycin cross-resistance but not streptomycin in M. avium-intracellulare complex
Lost to Amikacin? Streptomycin Might Still Work
This single-center retrospective study evaluated cross-resistance among aminoglycosides in 20 patients with amikacin-resistant M.
When amikacin fails to treat stubborn lung infections, streptomycin often remains effective, offering hope for patients facing drug-resistan…