N/A N=1,339 Implementation of Adverse Childhood Experiences (ACEs) Policy
Adverse Childhood Experiences
Primary: ACEs Screenings Reach — 0; 468; 73 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=318 The Impact of an Adapted Version of the Strengthening Families Program on IPV Among Caregivers and ACEs Among Children
Adverse Childhood Experiences · Domestic Violence
Primary: Adverse Childhood Experiences-Child Reported — 2.48; 3.80 Mean number of adverse experiences
Phase 4 N=40 Depression, Epinephrine, and Platelet Function
Major Depressive Disorder
Primary: Response of Participants, Defined by Change in the 21-item Hamilton Depression Rating Scale (HDRS) From Baseline to Week8 — 5; 9; 2; 4 participants — p=.918
N/A N=31 My Pathway to Healing
Suicide; Trauma · Binge Drinking
Primary: Number of Participants Completing Visits — 7; 11 Participants
N/A N=32 Activating and Connecting Teens (ACT) Study
Depression
Primary: Depression — 9.63 score on a scale
N/A N=39 Examining the Role of Pain in the Link Between Early Childhood Adversity and Psychopathology
Child Development
Primary: Pain Tolerance — 44.72; 45.09 seconds
N/A N=120 Adolescent Trauma Recovery and Stress Disorders Collaborative Care (ATRSCC) Model Program Trial
Post-traumatic Stress Disorder · Alcohol Abuse · Alcohol Dependence
Primary: Number of Patients With High Levels of Adolescent PTSD Symptoms — 9; 12; 11; 12 Participants — p=0.71
N/A N=880 Longitudinal Follow-up of Brief Parenting Interventions to Reduce Risk of Child Physical Maltreatment
Parenting · Child Behavior · Child Rearing
Primary: Parent - Change From Baseline Frequency of Corporal Punishment Use at 3 Months and at Long-term Follow-up — -.32; -.27; -.17; -.69 score on a scale
N/A N=43 Neural Changes Associated With a Mindfulness-based Intervention for Young Adults With Childhood Maltreatment
Depression · Anxiety · PTSD
Primary: Changes in Subjects' Perceived Stress Level — -5.526; 1.000 score on a scale
N/A N=426 A Randomized Controlled Trial to Improve Mother-Infant Synchrony Among Women With Childhood Adversity
Parent-Child Relations · Maternal Behavior · Infant Behavior
Primary: Mother-Infant Synchrony, Gaze and Affect — 113.89; 106.72; 28.2; 16.1 seconds of synchrony
N/A N=40 Mindfulness for Resilience in Early Life
Adolescent With Early Life Stress · Resilience
Primary: Cortisol Reactivity — -0.21; 0.34; 0.05; -0.08 μg/dL — p=<.05
N/A N=131 Neurobiological Responses in Alcoholism and Early Trauma
Alcohol Use Disorder · Early Trauma Complications
Primary: Brain Response — .015; .010; -.013; .08 unitless — p=<0.05
N/A N=123 Technology-Based Prevention for Adolescents in Primary Care
Substance Use
Primary: Enrollment and Recruitment Rate — 61; 62 Participants
Phase 1 N=81 Remote Mindfulness Training Following Early Life Adversity
Stress · Mindfulness · Early Life Adversity
Primary: Feasibility of Recruitment (Screened Eligible) — 81; 56; 112; 642 Participants
N/A N=28 Feasibility of a Culturally Adapted Emotional-Behavioral Prevention Program for American Indian Children
Anxiety Disorder · Depressive Disorder
Primary: Post-Intervention Youth-reported Anxiety Disorder Symptoms From Pre- to Post-Intervention — .94 mean score on scale
Phase 1 N=153 An Investigation of Early Life Stress and Depression
Major Depressive Disorder (MDD) · History of Childhood Sexual Abuse (CSA)
Primary: Dopamine Active Transporter Binding Potential — 3.191; 3.161; 3.175; 3.216 Ratio
N/A N=302 I-ACT With Check Yourself
Adolescent Behavior
Primary: Number of Health Risk Behaviors — 2.23; 2.62 score on a scale
N/A N=630 Maternal Adversity, Vulnerability and Neurodevelopment
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse) · Infant Development · Infant Behavior
Primary: Child's Cognitive Development Measured Using the Bayley Scales of Infant Development II. — 524; 508; 458; 422 Participants
N/A N=38 Attachment and Biobehavioral Catch-up and Depression Treatment
Maternal Depression · Child Behavior Problem
Primary: Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Depression Score — 6.70; 6.98 units on a scale — p=.85
N/A N=50 Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
Posttraumatic Stress Disorder · Substance Use Disorders
Primary: Posttraumatic Stress Disorder Checklist-Civilian Version — 31.45; 46; 18 score on a scale
N/A N=17 Pediatric Aggression and Violence
Pediatric Aggression and Violence
Primary: Salivary Hormone Correlation With Brief Rating of Aggression by Children and Adolescent (BRACHA) Score — 0.8; 0.4; 0.3; 0.4 ul/dL
N/A N=47 Healthy Bodies, Healthy Kids
Child Mental Disorders · Obesity · Metabolic Syndrome
Primary: DEXA-measured Adiposity — 0.76; -0.43; -2.79 kilograms — p=0.01
N/A N=146 Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
Risk-Taking · Adolescent Behavior
Primary: Changes in Emotional Regulation — 54.43; 52.02; 54.47; 60.77 T Score — p=0.003
N/A N=42 Attachment and Biobehavioral Catch-up for Depression
Depressive Symptoms · Anxiety Symptoms
Primary: Change From Baseline in Internalizing Subscale Score of the Child Behavior Checklist (CBCL) at Week 10 (Value at Baseline Minus Value at Post Intervention (Week 10))…
Phase 2 N=8 Healthy Heart Habits
Acute Coronary Syndrome · Depression
Primary: Acceptability Measured by the Client Satisfaction Questionnaire — 30.57 score on a scale
N/A N=33 Integrating Animal-Assisted Therapy Into Trauma-Focused Cognitive-Behavioral Therapy for Maltreated Youth
Child Abuse · Posttraumatic Stress
Primary: Change in Scores on the UCLA Posttraumatic Stress Disorder Reaction Index — 44.63; 39.5; 22.64; 35.85 units on a scale
N/A N=289 Comparative Effectiveness Trail to Reduce Child Maltreatment, Improve Client Outcomes and Examine Client Burden
Child Maltreatment
Primary: Parenting Young Children Scale-Supporting Positive Behavior Sub-scale — 6.14; 6.29; 6.43; 6.29 units on a scale — p=0.12
Phase 2 N=76 A School Program for Children Exposed to Violence
Stress Disorders, Post-Traumatic · Depression
Primary: Post-traumatic Stress Disorder Symptoms — 17.46; 19.41; 13.72; 18.32 units on a scale
N/A N=24 Promoting Resilience and Lowering Risk in Early Childhood
Child Abuse · Child Neglect · Parenting
Primary: Positive Parenting Practices: EMA Data Positive Parenting Activity Engagement — 3.75; 2.38 Daily number of activities — p=<0.01
N/A N=439 Preventing Alcohol Exposed Pregnancy Among Urban Native Young Women: Mobile CHOICES
Alcohol Exposed Pregnancy
Primary: Alcohol Use — 86; 82; 131; 137 Participants