Clinical Trial Search

Primary: Agreement Analysis (Agreement to Reference Standard) - Test Group — 76; 18; 2; 8 Participants

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Change in Cognitive Function as Measured Using the Extended Mini Mental State Exam — 0.58 Change on a scale

Primary: Change in Objective Cognitive Performance Composite z Score — .24; .14 Z score

Primary: Change in Readiness to Engage in ACP (ACP Engagement Scale) — 1.92; 1.54; 2.77; 2.00 units on a scale

Primary: Mean Change in ADL Score From Baseline to Week 10 — 0.00; -0.29 score on a scale

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: New Occurrence in Dementia Care-A Composite Endpoint Including New Cognitive Diagnoses, Laboratory Investigations Related to Cognitive Impairment, New Dementia…

Primary: Change From Baseline in Change From Baseline in Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB)…

Primary: Number of Participants With a Diagnosis of a Cognitive Impairment Disorder Measured by Pharmacological Interventions for the Management of Cognitive Impairment. — 0; 0…

Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05

Primary: MAAT-G Feasibility Completion Rate — 10 Participants

Primary: Rivermead Behavioral Memory Test — 11.08; 11.2; 12.31 units on a scale

Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01

Primary: Blood Brain Barrier Penetration of RAPA — 0 ng/ml

Primary: Changes in Cognitive Abilities of Memory From Baseline to Year 10 — -10.6; -11.2; -12.7; -9.4 units on a scale — p=0.43

Primary: Divided Attention Performance — 9.29; 9.31 difficulty level acheived

Primary: System Usability Scale (SUS) — 90.6 score on a scale

Primary: Selective Reminding Test (SRT) — 33.61; 36.23; 36.81; 37.13 Words

Primary: Change in Global Cognition Assessed by RBANS — 434.66; 435.36; 438.46; 436 Score on a Scale — p=0.9644

Primary: CRM Performance During First Sim Scenario Assessed by Ottawa Global Rating Scale (GRS) — -0.299 Pearson correlation coefficient — p=0.039

Primary: Percentage of Recruited Subjects Able to Comply With the Protocol — 12; 13; 3; 14 Participants

Primary: Participants With Depression by Patient Health Questionnaire - 9 — 177 participants

Primary: Change in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score From Baseline — 1.1; .9 score on a scale

Primary: Sleep Latency — 28.51; 47.06 minutes

Primary: Mean of the Functional Assessment of Cancer Therapy-Cognition (FACT-COG) — 155.8; 152.7 score on a scale

Primary: 15-Item Word List Delayed Recall — -0.3; -0.5 units on a scale - change from baseline — p=<.05

Primary: Knowledge of Memory Aging Questionnaire-Revised — 19.8; 19.5 units on a scale