Phase 4 N=60 Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Anesthetic Effectiveness
Primary: Successful Pulpal Anesthesia. — 37; 27; 22; 33 participants
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Phase 4 N=100 The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Pain
Primary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00
N/A N=100 Effect of Intra-cuff Lidocaine and Tetracaine on Tracheal Tube-induced Emergence Phenomena
Pharyngitis
Primary: Visual Analogue Scale(0-100mm) by the Subject. — 51; 40; 22; 9 mm
Phase 4 N=80 Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Anesthetic Effectiveness
Primary: Number of Participants Achieving Pulpal Anesthesia. — 52; 57 Participants
Phase 2 N=45 Safety and Effectiveness of Kovacaine Nasal Spray for Dental Anesthesia
Dental Anesthesia Efficacy
Primary: Pulpal Anesthesia — 25; 14 participants
Phase 3 N=646 Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Any Ear Nose or Throat Conditions · With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Primary: Immediate and Sustained Anesthetic Success for Cocaine HCl 4% Topical Solution and Placebo Topical Solution — 0.7093; 0.1969 proportion of participants — p=<0.0001
N/A N=30 Anesthesia With Endotracheal Laser Tube
Anesthesia · Anesthesia Morbidity
Primary: Number of Participants With Side Effects — 0 participants
Phase 3 N=110 Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth in Adults
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure After Without Need for Rescue by Injection of Local Anesthetic. — 84.1; 27.3; 27.3 percentage of patients
Phase 4 N=40 Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale
N/A N=109 Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Acute Otitis Media · Chronic Otitis Media · Recurrent Acute Otitis Media
Primary: Proportion of Subjects Who Achieved Anesthesia Effectiveness Per Investigator Assessment — 89.9 percentage of subjects
Phase 3 N=59 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
Pain, Procedural
Primary: Post Operative Pain — 13; 10 Participants
Phase 4 N=50 Lower Third Molar Removal With 2% and 4% Articaine
Impacted Third Molar Tooth · Adverse Reaction to Other Local Anesthetics
Primary: Onset of Anesthetic — 1.5; 1.5 minutes — p=0.192
N/A N=42 The Effect of Microneedle Pretreatment on Topical Anesthesia
Pain
Primary: Visual Analog Scale Pain — 7; 12 Units on a Scale
Phase 3 N=150 Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Adults
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure Without Need for Rescue by Injection of Local Anesthetic. — 88; 14 participants
N/A N=100 Trial of New Pretreatment Method in Transnasal Endoscopy
Pretreatment Method of Transnasal Endoscopy
Primary: Success Rate of Transnasal Endoscopy — 88; 88 percentage of Participants
Phase 4 N=31 Anesthetic Effect Duration Assessment
Healthy Volunteers
Primary: Duration of Anesthesia(Minutes) — 80; 140; 0; 400 Minutes
Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
Phase 4 N=201 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Irreversible Pulpitis
Primary: Anesthetic Success Rate of Supplemental Infiltration Injection — 22; 25; 23; 12 Participants — p=.901
Phase 2 N=75 Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
No Disease State or Condition
Primary: Stage II: Duration of Anesthesia as Measured by Pin Prick Test (PPT) for One Spray CTY-5339-A Compared to One Spray CTY-5339-CB — 14.6; 7.4 minutes
Phase 1 N=16 A Study of the Use of Microneedle Patches to Deliver Topical Lidocaine in the Oral Cavity
Topical Anaesthesia
Primary: VAS in Healthy Participants, When Topical 5% Lidocaine Dental Gel Was Applied to the Upper Palatal and Upper Anterior Buccal Sulcus Areas With a Microneedle Patch and a…
N/A N=91 Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local Anesthetics
Methemoglobinemia
Primary: Peak Methemoglobin Blood Levels — 3.55; 1.63; 1.60 percentage of methemoglobin in blood — p=<.001
N/A N=96 Comparing Two Anesthetic Techniques for Implant Placement
Edentulous Jaw · Dental Implant · Anesthesia, Local
Primary: Pain Perception by Numerical Rating Scale — 0; 0 score on a scale
N/A N=49 Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Anesthesia
Primary: Participants Anesthetic Preference — 32; 16 participant preference selection
N/A N=60 Effect General and Regional Anesthesia on Glycocalyx
Anesthesia · Glycocalyx · Perfused Boundary Region
Primary: Change in Perfused Boundary Region (PBR) — 2.20; 2.09 micrometer
Phase 4 N=103 Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
Eyelid Tumor · Eyelid Bump · Eyelid Deformity
Primary: Pain on Injection — 2.8; 3.6 score on a scale
N/A N=57 Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival
Age-related Macular Degeneration · Central Retinal Vein Occlusion · Diabetic Macular Edema
Primary: Number of Participants Who Preferred Subconjunctival Anesthetic at the Third Follow-up Visit — 50 participants
Phase 4 N=35 Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
Endodontic Disease · Post Operative Pain · Symptomatic Irreversible Pulpitis
Primary: Post-operative Pain Level 6 Hours on a Visual Analog Scale — 64.2; 43.1 units on a scale
N/A N=76 Local Anesthesia and Pain Perception During an Amniocentesis
Pregnancy
Primary: Intensity of Perceived Maternal Pain as Measured by the Visual Analogue Scale (VAS) — 9.5; 18.4 units on a scale
Phase 4 N=120 Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol
Esophagogastroduodenoscopy
Primary: Rate of Administration of Propofol 1% Required to Obtain Uniform Sedation During Endoscopy — 310.7; 280.1 mcg/kg/min — p=<0.05
Phase 3 N=90 Comparison of Intranasal Kovacaine Mist, and Placebo for Anesthetizing Maxillary Teeth in Pediatric Patients
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure Without Need for Rescue by Injection of Local Anesthetic. — 46; 16 Participants