Clinical Trial Search

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Cerebral Metabolic Rate of Oxygen (CMRO2) — 8.17 micro-mol/100g/min

Primary: Composite Global Cognitive Function — .15; .02 Z-score

Primary: Functional Connectivity Strengths of Neural Networks — 0.233; 0.318 Pearson coefficient — p=0.007567

Primary: Change of C3 Activation (NPS-shared Neural Circuit Measure — -0.15; 0.01 change of arbitrary unit LPG activation — p=<0.05

Primary: Change in Magnetoencephalography (MEG) Connectivity Measures

Primary: Working Memory — 0.86; 0.04 digits recalled

Primary: Rivermead Behavioral Memory Test — 11.08; 11.2; 12.31 units on a scale

Primary: Percentage of Trials Correct On Working Memory Test — 87.69; 91.57; 88.01; 91.68 percentage of correct trials — p=>0.05

Primary: One-card Learning (OCL) Measurement Over 12 Weeks of Treatment — 0.954; 0.942; 0.822; 0.969 Score on a scale

Primary: Differences in Error Rates on the NBack Task Between Real and Sham Stimulation Trials — -0.79; -0.1 incorrect responses

Primary: Cortical Excitability: Resting Motor Threshold (RMT). — 51.1; 51.8 % of Max Stimulation Output (MSO)

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale

Primary: Percent Change From Baseline to Week 12 Based on Hippocampus Connectivity Index (HCI) — 7.47 percent change

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Change in Hippocampal-dependent Learning — -.00369; .00404 learning rate (proportion correct/trial) — p=<.05

Primary: Accuracy on the Tower of London Task — 81.2; 82.3; 88.1; 84.0 percentage of correct responses

Primary: Blood Brain Barrier Penetration of RAPA — 0 ng/ml

Primary: Change From Baseline in Averaged Correct Response Rate on the One Card Learning Task to Week 8 — 0.055; 0.034 Proportion of correct response

Primary: Verbal Memory Score Change — -0.08; -0.08; 0.18; -0.47 score on a scale

Primary: Leisure Activities Questionnaire Activities Sum — 1.45; 4.45; 11.25 score on a scale — p=<0.05

Primary: Neuropsychological Performance in Neuropsychological Test: Verbal Learning Memory Test (VLMT) — 57.2; 57.2 score on a scale — p=0.74

Primary: Change in Clinical Disease Severity (CDR) — -0.1; 0.0; 0.0; 0.0 score on a scale

Primary: Magnetic Resonance Spectroscopy (MRS) Will Measure a Change in Cerebral Energy Function in Brain Tissue — .011; .007; .009; .006 Difference in metabolite amplitude

Primary: Percentage of Recruited Subjects Able to Comply With the Protocol — 12; 13; 3; 14 Participants

Primary: Amyloid Deposition Obtained on a 18F-flutemetamol Brain Scan. — 1.65 ratio of flutemetamol absorbed — p=<0.05

Primary: Mean in the Prefrontal Executive Function Z-score (PEF6_6) — 0.121; 0.213; 0.270 Z-score — p=0.06

Primary: Change in Cognitive Function, as Measured by Number Correct on the Digit Symbol Matching Task — 63.0; 63.5; 67.8; 69.0 number of correct matches — p=0.54

Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05