Clinical Trial Search

Primary: Change From Baseline in the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Score at 1 Year — 23.3; 9.9 scores on a scale — p=<0.01

Primary: The Lysholm Knee Score — 82.2; 83.4 units on a scale

Primary: Number of Participants With Viable Specimens for Genetic Analysis — 14 participants

Primary: Change in Pain on the VIsual Analog Scale (VAS) — -.068 change in units on a scale from baseline

Primary: Change From Baseline in Cartilage Volume in the Index Region of the Target Knee by MRI — 94.6; 9.3 µL — p=0.0575

Primary: Summary of Adverse Events — 2; 2; 3; 2 Adverse events

Primary: IKDC Score — 32.0; 25.5 score on a scale

Primary: WOMAC Functional Status - Difference From Baseline — 20.9; 18.5 Score — p=0.26

Primary: Degree of Filling of the Lesion by Repair Tissue at 12 Months Through MRI. — 92.81; 85.22 Percentage of lesion fill — p=0.011

Primary: KOOS4 - Change From Baseline — 24.4; 25.3 units on a scale — p=<0.05

Primary: Change in International Knee Documentation Committee (IKDC) Subjective Knee Form Score — 22.2; 20.6 units on a scale

Primary: Change Form Baseline in WOMAC A Pain Subscale — -11.14; -11.82 cm — p=<0.025

Primary: Feasibility and Safety of the Implementation of MSV in the Treatment of Osteoarthritis of the Knee. — 46.9; 25.1; 24.8; 15.4 units on a scale

Primary: Cross-sectional Area (CSA) of Muscle Fibers — 2680; 2377; 2028; 1882 micron squared

Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months — 27.1; 33.3; 28.9; 26.7 units on a scale

Primary: Knee Flexion Moment Impulse — 0.54; 0.50 Ratio — p=0.293

Primary: Medial Condylar Separation With Brace — 0.60 mm

Primary: Infrapatellar Fat Pad Volume in MRI — 25154.96; 29202.39 mm^3

Primary: Change of External Knee Adduction Moment as Assessed by Visual Motion Analysis System — 0.50 Nm/kg

Primary: Change From Baseline to Week 104 for the Participant's Knee Injury and Osteoarthritis Outcome Score (KOOS) Pain and Function (Sports and Recreational Activities) Scores…

Primary: Change in Numerical Pain Scale — -3.2 units on a scale

Primary: Change in Hyaluronate Concentration — 0.29568 mg/ml

Primary: Patient Function (Units on a Scale) — 31 units on a scale

Primary: Safety: Adverse Events — 0 participants

Primary: Change in Minimum Joint Space Width in the Medial Compartment of the Tibiofemoral Joint of the Signal Knee After 1 Year of Treatment — -0.1361; -0.0442; -0.2261; -0.2000…

Primary: Number of Participants Experiencing One or More Treatment-Emergent Adverse Event — 28; 33 Participants — p=>0.9

Primary: Histomorphometry Safranin-O + Anti-Collagen II Antibody Staining — 1.01; 0.75 Ratio — p=0.003

Primary: Number of Participants With Adverse Events as a Measure of Safety and Tolerability — 14; 13 participants

Primary: Pain Sensitivity: Pressure Pain Detection Threshold (PPT) — 252.58; 266.17 kPa

Primary: To Identify Imaging Markers for Characterizing the Biochemical Profiles in Synovial Fluid and Cartilage in Knee OA After HA Injection