N/A N=147 Specified Drug-use Survey of Fomepizole Intravenous Infusion (All-case Surveillance)
Ethylene Glycol Poisoning, Methanol Poisoning
Primary: Number of Participants Reporting One or More Adverse Events (AEs) — 22 Participants
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=21 Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing
Acetaminophen Toxicity
Primary: Rise in Plasma Transaminases: Proportion of Responders. — 6; 8 Participants — p=0.59
Phase 2 N=32 Phase IIa Study of Fomepizole for Acetaldehyde Toxicity After Ethanol Exposure in Subjects With Altered Ethanol Metabolism
Aldehyde Dehydrogenase-2 (ALDH2) Deficiency
Primary: Number of Participants With Adverse Events (AEs), Serious AEs, and AEs Leading to Study Discontinuation — 13; 6; 8; 21 Participants
Phase 2 N=31 Systemic and Local Diffusion of Ethanol After Administration of Ethanol 96% Formulated in a Gel and Ethanol 98% Solution by the Percutaneous Route, in Patients With Congenital Venous Malformations:Pharmacokinetic, Pharmacodynamic and Clinical Study.
Congenital Venous Malformation
Primary: Systemic Exposure to Ethanol With the Two Test Products: Determination of the Maximum Plasma Concentration (Cmax) — 0.0604; 0.202 g/L
N/A N=14 Pharmacotoxicology of Trichloroethylene Metabolites
Congenital Lactic Acidosis
Primary: Hypothesize That Subject's Genotype Will Determine How DCA is Metabolized. — 1592; 232 Minutes — p=0.023
Phase 2 N=7 Pharmacotoxicology of Trichloroethylene Metabolites
Healthy
Primary: Plasma DCA (Microgram/ml) After 5 Days of Therapeutic Level Chloral Hydrate on Arm 2A. — 1.64 micrograms/ml
Phase 4 N=5 Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affecting Efficacy
Overdose
Primary: Absorption of Acetaminophen as Indicated by Area Under the Curve — 3566; 3335 mcg*min/mL
Phase 4 N=122 Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department
Nausea
Primary: Nausea 100 mm Visual Analogue Scale (VAS) — 23; 19; 42 units on a scale
N/A N=102 European Survey: Risk of Cyanide Poisoning in Smoke Inhalation
Smoke Inhalation Patients
Primary: Overall Survival After 24 Hours — 96 participants
N/A N=360 Alcohol Metabolism and Disease Risk in Asians
Healthy
Primary: Peak Number of Alcohol Drinks Consumed in a Day — 3.7; 4.2; 3.4; 3.0 drinks — p=.81
Phase 4 N=15 Effect of Ethanol Intoxication on the Anti-Hypoglycemic Action of Glucagon
Type 1 Diabetes Mellitus
Primary: AOCGIR (Area Over the Curve for Glucose Infusion Rate) — 1996; 1981 mg*minute/dl
Phase 1 N=10 Pilot Study of the Safety of a Daily Ethanol Lock for Urinary Catheters in Critically Ill Children
Complication of Urinary Catheter
Primary: Blood Alcohol Level — 0 Participants
Phase 3 N=47 Glucarpidase Effect on Severe Delayed HDM-clearance in Children Treated With High-dose Mtx in ALL
Acute Lymphoblastic Leukemia (ALL)
Primary: Number of Participants With Adverse Event to HD-MTX Treatment in NOPHO ALL-2008 as a Measure of Toxic Mtx Concentrations in Blood, Nephrotoxicity, Hepatotoxicity…
N/A N=126 Ethyl Chloride Vapocoolant as Anesthesia for Arterial Punctures
Anesthesia · Pain
Primary: Pain Level on the Visual Analog Scale (NRS-11) — 2; 2 scores on scale
Phase 2 N=30 Caffeinol Hypothermia Protocol
Acute Ischemic Stroke
Primary: Number of Participants With Symptomatic Intracerebral Hemorrhage — 0 participants
Phase 2 N=60 Prevention of Alcohol Intolerance
Alcohol Sensitivity
Primary: Mean Area of Skin Erythema (Skin Redness) — 3.968; 1.739 centimeters^2
Phase 4 N=27 Preemptive Ethanol Lock Therapy in Pediatric Bloodstream Infection
Leukemia · Lymphoma · Blood Disorders
Primary: Length of Stay (LOS) in Those With 14 Confirmed Catheter Related Infection Cases — 124; 208 HOURS
N/A N=17 Phenytoin and Multidose Activated Charcoal
Phenytoin Toxicity
Primary: Time of Elimination of Phenytoin in Patients With Elevated Phenytoin Levels — 41.1; 19.3 hours — p=0.049
N/A N=50 Efficacy Study of Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®) Versus Lactulose in Patients With Hepatic Encephalopathy.
Hepatic Encephalopathy · Cirrhosis · Portosystemic Encephalopathy
Primary: Number of Participants With an Improvement of 1 or More in HE Grade at 24 Hours — 21; 13 participants
N/A N=51 Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Hypotension · Anesthesia
Primary: Number of Participants Who Had Hypotensive Events — 8; 21 Participants — p=0.01