N/A N=133 Executive Dysfunction and Suicide in Psychiatric Outpatients and Inpatients
Traumatic Brain Injury · Suicidality
Primary: Iowa Gambling Test — -4.2; 1.7; 3.5; 5.3 Total Raw on a scale from -100 to 100 — p=>.05
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=12 Treatment of Executive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Clinical Global Impression of Change-Clinician Rated Score (CGIC-C) — 3; 6; 1; 2 Participants
N/A N=49 Cognitive Dysfunction in Parkinson's Disease
Parkinson's Disease
Primary: Change in Magnetoencephalography (MEG) Connectivity Measures
N/A N=95 Cognitive Dysfunction In Parkinson's
Parkinson's
Primary: Differences in Error Rates on the NBack Task Between Real and Sham Stimulation Trials — -0.79; -0.1 incorrect responses
N/A N=19 Maintaining Autonomy as we Age. Strategy Training for Age-related Executive Dysfunction.
Aging
Primary: Total Number of Goals Improved to Criterion on the Canadian Occupational Performance Measure (COPM) — 50; 19.6; 50; 32.6 percentage of untrained goals improved — p=0.03
Phase 4 N=33 Modafinil for Treatment of Cognitive Dysfunction in Schizophrenia
Schizophrenia · Schizoaffective Disorder
Primary: Percent Change in Accuracy on High-control (i.e., Difficult) Condition of Preparing to Overcome Prepotency Task — 8.6; 9.2 percent change in accuracy
Phase 4 N=22 Efficacy of Lisdexamfetamine Dimesylate for Promoting Occupational Success in Young Adults With ADHD
Attention Deficit Disorder With Hyperactivity
Primary: Ratings of Job Application Quality — 3.40; 3.56 score on a scale
Phase 2 N=143 SPD489 in Adults With Persistent Executive Function Impairments (EFI) and Partial or Full Remission of Recurrent Major Depressive Disorder
Major Depressive Disorder
Primary: Change From Baseline in Behavior Rating Inventory of Executive Function - Adult Version Global Executive Composite T-score (BRIEF-A GEC T) at Week 9, Last Observation…
N/A N=123 Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
Cognitive Aging
Primary: Mean in the Prefrontal Executive Function Z-score (PEF6_6) — 0.121; 0.213; 0.270 Z-score — p=0.06
N/A N=10 Transcranial Direct Current Stimulation (tDCS)
Brain Fog
Primary: Perceived Ease of Use After 4 Weeks of Daily tDCS Use (TAM Score) — 30.5 units on a scale
N/A N=91 Executive Functioning in TBI From Rehabilitation to Social Reintegration: COMPASS
Traumatic Brain Injury · Post-Traumatic Stress Disorder
Primary: Change From Baseline in Community Reintegration for Injured Service Members at 2 Months — 40.22; 37.79 score on a scale
N/A N=35 Neural Bases of Cognitive Rehabilitation for Brain Injury
Brain Injury
Primary: Change From Baseline on a Composite Measure (Z-score) of Attention, Working Memory, and Executive Functions — 0.26; .01 Change to Z (composite) score
N/A N=46 Targeting Self-regulatory Deficits Through Cognitive Remediation Intervention
Drug Use Disorders
Primary: Change in Stop Signal Reaction Time — -8.62 ms — p=.003
Phase 3 N=52 Study of the Duration and Efficacy of MYDAYIS on Adult ADHD Symptoms and Executive Function Throughout the Day Into the Early Evening
Attention Deficit-Hyperactivity
Primary: Adult ADHD Investigator Symptom Rating Scale (AISRS) Score at End of Placebo Lead-In — 37.2 score on a scale
Early Phase 1 N=54 Cognitive Rehabilitation in Parkinson's Disease
Parkinson's Disease
Primary: Reaction Time and Variability for Movement Task — 1013.858333; 994.94875; 979.2450877; 910.9120833 milliseconds
Phase 4 N=28 Mild Cognitive Impairment in Parkinson's Disease
Parkinson's Disease · Mild Cognitive Impairment
Primary: Alzheimer's Disease Cooperative Study- Clinical Global Impression Change (ADCS-CGIC) — 3.92; 3.48 scores on the CGIC
N/A N=110 Cognitive Rehabilitation for PD
Parkinson's Disease
Primary: Wechsler Adult Intelligence Scale-IV (WAIS-IV) Matrix Reasoning Test Total Scaled Score — 0.22; 0.42 score on a scale — p=0.6662
Phase 4 N=159 Safety and Efficacy of SPD489 on Executive Function Behaviors in Adults With Attention-Deficit/Hyperactivity Disorder (ADHD)
ADHD Specifically With Executive Function Impairment
Primary: Change From Baseline in Subject-reported Behavior Rating Inventory of Executive Function - Adult Version Global Executive Composite T-score (BRIEF-A GEC T) at up to 10…
Phase 4 N=106 Aging Brain Changes, Executive Dysfunction and Depression
Depression
Primary: Hamilton Depression Rating Scale. — 8.09 units on a scale
N/A N=57 Feasibility and Effect of a Strategy-Based Cognitive Intervention for Parkinson Disease
Parkinson Disease
Primary: Change in Bangor Goal Setting Interview (BGSI) Goal Attainment — 4.5; 4.6; 5.9; 7.4 score on a scale
N/A N=33 Treatment for Executive Dysfunction in Adult Survivors of Childhood Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
Primary: Feasibility of At Home tDCS Intervention — 25 Participants
Phase 4 N=50 Effects of LDX on Functioning of College Students With ADHD
Attention-deficit/Hyperactivity Disorder
Primary: Conners Adult ADHD Rating Scale - Short Version (CAARS) — 50.59; 46.86; 47.32; 45.36 T score — p=<0.001
N/A N=26 Memantine for Executive Dysfunction in Adults With ADHD: A Pilot Study
Attention Deficit Hyperactivity Disorder (ADHD) · Executive Function Deficits (EFD)
Primary: Percent Change in Global Executive Composite T-Score on the Behavior Rating Inventory of Executive Function-Adult (BRIEF-A) — -24; -21 percentage change from baseline…
Early Phase 1 N=35 Remediation of Impaired Self-Regulation in Patients With Mild TBI
Mild Traumatic Brain Injury
Primary: Blood Oxygen Level Dependent (BOLD) Brain Signal Measured Using Functional MRI. — 270; 111 voxels — p=<0.0001
N/A N=59 Brain Plasticity Underlying Acquisition of New Organizational Skills in Children
ADHD · Attention Deficit Hyperactivity Disorder · Neurodevelopmental Disorders
Primary: Change in the Intrinsic Functional Connectivity (iFC) Between Dorsal Anterior Cingulate Cortex (dACC) and Default Mode Network Subdivision of the Anterior Ventral…
N/A N=35 Investigating the Causal Role of Prefrontal Control in Decision-making in Patients With Anhedonia
Major Depressive Disorder · Anhedonia
Primary: Change in the Percentage of Trials That the Participant Chooses to Perform the Hard Task — -0.30; -0.22; -0.09 percentage of trials — p=0.049
Phase 2 N=4 Enhancing Attention in Adults With Compulsive Hoarding
Hoarding Disorder
Primary: Number of Patients Who Met and Exceeded Response Criteria of Attention Deficit Hyperactivity Disorder Symptom Scale — 4 participants
N/A N=106 The Role of Apathy in Glycemic Control
Apathy · Diabetes
Primary: Change in HbA1c Over Baseline — -1.0; -0.1 percentage of HbA1c
N/A N=78 Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
Alzheimer Disease · Dementia
Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items
Phase 3 N=598 Efficacy Study of Vortioxetine on Cognitive Dysfunction in Adult Patients With Major Depressive Disorder
Major Depressive Disorder
Primary: Change From Baseline to Week 8 in DSST (Number of Correct Symbols) and RAVLT (Acquisition and Delayed Recall) Using the Composite Z-score Defined as the Weighted Sum of…