Early Phase 1 N=32 Premature Fatigue in Veterans With Heart Failure: Neuronal Influences
Heart Failure
Primary: Maximal Voluntary Quadriceps Force [% Change From Baseline] — -30; -5 percentage change
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=20 Mechanisms to Reduce Mental and Physical Fatigue Following Exercise Training in Older Adults
Fatigue · Aging
Primary: Fatigue — -5.6; -4.1 change in fatigue severity score
Phase 4 N=50 Physiological and Psychological Effects of Testosterone During Severe Energy Deficit and Recovery
Caloric Restriction · Exercise
Primary: Body Composition at the End of Each Study Phase — 78.3; 78.0; 73.3; 75.8 kilograms
N/A N=34 Blood Lactate Concentrations With and Without Exercise in Parkinson's Disease and Multiple Sclerosis Patients
Parkinson's Disease · Multiple Sclerosis
Primary: Blood Lactate Response — 1.7; 1.6; 1.2; 2.3 mmol/L
N/A N=20 The Psychophysiological Effect of Simulated and Terrestrial Altitude
Hypoxia · Altitude Hypoxia · Altitude Sickness
Primary: Oxygenation of the Brain — 54.6; 54.3; 59.4; 55.4 percentage of oxygen saturation
N/A N=90 Mindfulness, Mental Fatigue, Inhibitory Control and Endurance Performance in Athletes
Mental Fatigue
Primary: Inhibitory Control: Reaction Time — 461.01; 448.68; 444.35; 465.88 millisecond
N/A N=32 Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.
Exhaustion - Physiological
Primary: Relative Maximal Oxygen Uptake — 47.8; 50.9; 49.7; 51.7 mL/(kg*min) — p=< 0.05
N/A N=53 Mindfulness Training, Mental Fatigue, Endurance Performance and Neurocognitive Functions
Mindfulness Training · Neurocognitive Function · Sports Performance
Primary: Inhibitory Control: Reaction Time — 10.79; 5.47; 4.11; -0.61 millisecond — p=> 0.05
N/A N=10 Combined and Isolated Effects of Sleep Deprivation and Alcohol Intake on Exercise Performance in Humans.
Alcohol Intake · Sleep Deprivation
Primary: Aerobic Performance — 172; 173; 175; 176 bpm
N/A N=16 Effect of Exercise on the Human Skeletal Muscle Phosphoproteome
Skeletal Muscle Protein Synthesis
Primary: Change in Acute Muscle Protein Synthesis — 143; 123 percent change
N/A N=30 Impact of Nutritional Supplementation on Aerobic Performance and Fatigue
Performance · Fatigue
Primary: Perceived Exertion — 6.7; 7.4 units on a scale
Phase 4 N=8 Impact of Erythropoietin on Hematological Adaptations and Physical Performance
Exercise-Induced Anemia · Physical Performance
Primary: Concentration of Hemoglobin — 1.46 g/dL
Phase 2 N=39 Evaluation of Cortisol Resistance in Young Sedentary and Endurance-Trained Men
Cortisol Resistance · Negative Feedback · ACTH
Primary: Proportion of Suppressors After Dexamethasone — 0; 1 Participants — p=0.4872
N/A N=50 Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Abnormality, Respiratory System · Autonomic Nervous System
Primary: FEV1 — 0.94; 1.08; 0.95; 1.09 percentage of predicted normal values
Phase 2 N=32 Exercise Intolerance in Renal Failure
Kidney Failure, Chronic
Primary: Change in Resting Muscle Sympathetic Nerve Activity (MSNA) — -7.5; 3.2 bursts/minute
N/A N=47 Females, Aging, Metabolism, and Exercise
Obesity
Primary: Change in Physical Activity Energy Expenditure (PAEE) — 74.5; -10.2; 61.0 kcal/day
N/A N=105 Effects of Fast Bar on Physiological Fasting
Fasting
Primary: Ketone Area Under the Curve — 1.27; 0.62; 1.17 mg/dL*h
N/A N=94 Gas Exchange Kinetics and Work Load During Exercise
Methods of Exercise in Children
Primary: Maximum Oxygen Uptake (VO2) Measurements During Exercise — 1.6; 2.8; 3.2; 1.7 L/min
N/A N=28 The Psychoneuroimmunology of Insomnia
Primary Insomnia
Primary: Positive Antibody Response — 7; 7 participants
N/A N=1,189 Fire Fighter Fatigue Management Program: Operation Healthy Sleep
Shift-Work Sleep Disorder · Insomnia · Restless Leg Syndrome
Primary: Firefighters' Health, as Determined by Number of 'Sick' Days Over 12 Months — 3.1; 3.2; 1.4; 2.6 days/firefighter — p=0.66
N/A N=15 Fatiguing Arm Exercise Following Stroke
Stroke
Primary: Short Intracortical Inhibition (SICI) — 0.83; 1.14; 0.89; 0.88 SICI ratio — p=0.15
Phase 3 N=80 Post Traumatic Stress Disorder (PTSD) Hyperarousal Symptoms Treated With Physiological Stress Management
Stress Disorders, Post-Traumatic
Primary: Change Scores for Criteria D Items on the CAPS Structured Clinical Interview — -1.20; -6.27 units on a scale — p=.27
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
Phase 2 N=64 Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Cystic Fibrosis
Primary: Percentage Flow-Mediated Dilation (FMD) — 5.64; 5.32; 6.29; 7.21 percentage of change in FMD
N/A N=18 The Effect of Sildenafil and Tadalafil on Skeletal Muscle and Perceptual Fatigue
Fatigue
Primary: Skeletal Muscle Fatigue as Measured by Biodex 4 Pro After 4 Weeks of Placebo — 59.69; 42.07; 67.17; 63.24 Newton-Meters
N/A N=14 Vascular Dysfunction During Physical Inactivity
Aging · Vascular Endothelium · Skeletal Muscle
Primary: Brachial Artery Vascular Function — 5.1; 3.1; 4.4 percent vasodilation
N/A N=12 Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
Fatigue · Aging
Primary: Change in Muscle Fatigue After 1 Week of Placebo or Sildenafil — 107; 115; 54; 158 percent change of successful repetitions — p=0.02
N/A N=10 Circadian Rhythm Disruption Effects on Smoke Inhalation
Inflammation · Sleep Deprivation · Circadian Rhythm Sleep Disorder, Shift Work Type
Primary: Blood Inflammation — 0.69; 0.79; 2.33; 1.63 pg/mL — p=<0.05
Phase 2 N=45 The Exercise Response to Pharmacologic Cholinergic Stimulation in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome · Chronic Fatigue Syndrome · Myalgic Encephalomyelitis
Primary: Change in Peak Oxygen Uptake (Peak VO2) Between the First and Second iCPET — 13.3; -40.3; 111.8 mL/min — p=0.043
N/A N=40 A Study to Asses Wellness Using a Brain Sensing Device on Physicians
Stress, Emotional · Sleep · Quality of Life
Primary: Frequency Adherence to Intervention — 57.8 times used