Phase 2 N=12 Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans
Healthy
Primary: Plasma Half Life of Labeled Carotenoid — 6.2; 2.3 days
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=16 Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot
Focus of Study: Carotenoid Absorption
Primary: Pharmacokinetics of Carotenoid Absorption From Papaya, Carrot and Tomato — 163; 62; 64; 174 nmol*h/L
Phase 2 N=47 Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects
Nutrient Deficiency · Pregnancy Related
Primary: Change in Maternal Macular Carotenoid Levels From Enrollment to Birth of Infant — 12244; 7343 unitless
N/A N=162 Examining Validity and Sensitivity of Pressure-Mediated Reflection Spectroscopy
Dietary Habits · Diet, Healthy
Primary: 3-week Change in Skin Carotenoid Status — 28.0; 62.3; 9.34 units on a scale
N/A N=81 Correlation Between Skin Carotenoid Levels and Previous History of Skin Cancer
Skin Cancer · Basal Cell Carcinoma · Squamous Cell Carcinoma
Primary: Skin Carotenoid Levels in Subjects With History of Squamous Cell Carcinoma Versus Control Subjects — 27,635; 31,219 Raman spectroscopy intensity counts — p=0.31
N/A N=20 Family-based Lifestyle Intervention Program and Carotenoid Supplementation for Children With Obesity
Pediatric Obesity
Primary: Change in β-carotene — .127; .116; .224; .107 ug/mL
N/A N=10 Matrix on Fruit Constituent Bioavailability
Healthy Non-smoker
Primary: CMax in Polyphenol Anthocyanin Concentrations — 8.7; 22.1; 7.6; 11.3 nmol/L
Phase 3 N=192 Effects of Lutein Supplementation on Subclinical Atherosclerosis
Carotid Atherosclerosis · Carotid Intimal Medial Thickness 1
Primary: Table 1 Study Specific Characteristic Part One — 69.8; 59.8; 59.1; 72.7 Percentage of Participants — p=>0.05
N/A N=8 Achieving Nutritional Adequacy Of Vitamin E With An Egg/Plant-Based Food Pairing
Nutritional Requirements
Primary: Vitamin E Area Under the Curve (0-72 h) — 2.90; 5.24; 5.18; 4.39 umol/L*h
N/A N=60 The Zeaxanthin and Visual Function Study
Age Related Macular Degeneration · Cognition Disorders
Primary: Macular Pigment Optical Density — 0.48; 0.38; 0.42 Density units of Macular Pigment (du)
N/A N=48 Scavenging of Reactive Carbonyl Species by Dietary Flavonoids in Humans
Human Health · Reactive Carbonyl Species · Polyphenols
Primary: Change in Urinary Levels of Reactive Carbonyl Species (RCS) of Soymilk, Green Tea, or Blueberry Over 8 Hours After One Single Dose of Soymilk, Green Tea, or Blueberry…
Phase 2 N=80 The Moran AMD Genetic Testing Assessment Study
Age-Related Macular Degeneration · Genetic Testing · Nutritional Biomarkers
Primary: Change in Skin Carotenoid Status in Response to Genetic Risk Disclosure as Measured by Reflectance Spectroscopy — 257.7; 290.9 Reflection units (RU)
N/A N=6 ABSORB (Amount of Blueberries So Older Adults Reap Benefits)
Depressive Symptoms · Aging
Primary: Urinary Flavonoid Biomarkers — 398863; 1045795 Unitless
N/A N=29 Evaluating the Availability of Berry Phytonutrients Post-consumption of Fresh and Processed Blueberry by Healthy Adults
Healthy
Primary: Total Urinary Recovery of (Poly)Phenolic Metabolites Across Treatments — 179.50; 142.41; 127.78; 83.15 mg — p=<0.05
N/A N=10 Physiological Effects of New Polyphenol-enriched Foods in Humans
Healthy
Primary: Serum Polyphenol Concentrations Over 24h From Food Consumption — 1.7; 12.1; 7.7; 0.01 nmol*h/L — p=0.02
N/A N=11 Gastric pH and Anthocyanin Absorption
Anthocyanin Metabolism
Primary: Gastric pH — 0.96; 2.31 pH
N/A N=17 Effects of Calcium and Phytate on Zinc Absorption
Dietary Zinc Absorption
Primary: Zinc Absorption — 32.8; 26.9; 39.4; 26.2 Percentage of Zinc-65 absorbed — p=0.17
N/A N=37 Adherence Dynamics for Whole Food Interventions in African-American Men
Healthy
Primary: Tomato Product Intake Between Different Groups — 6.1; 0.0 servings/week
N/A N=22 A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria
Secondary Hyperoxaluria · Nephrolithiasis · Hyperoxaluria
Primary: Percent of Oxalate Absorption Normalized by Baseline Urinary Oxalate Excretion Over a 24 Hour Test Period — 2.84 percentage of oxalate absorption
Phase 1 N=72 Assessment of the Human Systemic Absorption of Sunscreen Ingredients
Systemic Exposure to Sunscreen Ingredients
Primary: Avobenzone Maximum Concentration — 1.8; 4.3; 4.0; 3.4 ng/mL
N/A N=297 WIC-Based Intervention to Promote Healthy Eating Among Low-Income Mothers
Cancer Prevention · Diet Modification · Vegetable Intake
Primary: Vegetable Intake Carotenoid Scores at 3 Months — 227.11; 269.98 units on a scale — p=0.001
N/A N=39 Fruit and Vegetable Juice Concentrate Effects on RBP4 and Antioxidant Capacity in Lean and Overweight 6-10 Year Old Boys
Obesity
Primary: Beta-carotene Levels Between Overweight and Lean Boys at Baseline — 0.22; 0.29 mM/L
N/A N=109 Macular Pigment and Glare Disability
Vision, Entoptic
Primary: Macular Pigment Optical Density — 0.54; 0.42 optical density — p=0.01
Phase 1 N=24 Bioavailability Study of COQUN ORAL FORMULATION
Male & Female Healthy Volunteers
Primary: Analysis of Pharmacokinetic Property "Area Under the Curve" — 2657.45; 3459.05 microg/l*days
N/A N=168 Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular Degeneration
Age-related Macular Degeneration
Primary: Changes of Macular Pigment Optical Density (MPOD) During 48 Weeks and 2 Years — 0.315; 0.307; 0.315; 0.320 density units — p=<0.05
N/A N=16 Iron Bioavailability From MyPyramid Menus
Nonheme Iron Absorption
Primary: Nonheme Iron Absorption — 2.31 percentage of nonheme Iron absorbed
N/A N=25 Investigation of Iron Uptake From Micronutrient Fortified Powder Versus From Tailored Control in Milk
Growth and Development
Primary: Fractional Iron Absorption — 2.08; 1.25 % Iron Absorbed — p=0.0944
Phase 3 N=4,203 Age-Related Eye Disease Study 2 (AREDS2)
Age-related Macular Degeneration · Cataract
Primary: Development of Advanced AMD in People at Moderate to High Risk for Progression. — 493; 468; 507; 472 Eyes — p=<0.013
Phase 3 N=59,721 Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh
Vitamin A Deficiency · Maternal Mortality · Infant Mortality
Primary: All-cause, Pregnancy-related Mortality — 41; 47; 50 Participants — p=0.05
Phase 4 N=26 Effects of Ezetimibe on the Absorption of Oxidized Cholesterol
Hypercholesterolemia
Primary: Log[Area-under-the-plasma-concentration-curve(AUC) 0-8 Hours 7-ketocholesterol] After an Oral Bolus — 1.925; 2.177 Log(mg*hr/dl) — p=0.03