N/A N=32 High Flow Nasal Cannula for Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Apnea Hypopnea Index — 6.15; 14.85 events per hour — p=<0.001
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=80 Physiological Changes With High-Flow Nasal Cannula
Respiratory Distress Syndrome in Premature Infant
Primary: Percent of Unventilated Lung as Assessed by Electrical Impedance Tomography — 2.18; 2.32; 1.72; 2.17 Percent of unventilated lung regions
N/A N=21 HFNC Flow Titration and Effort of Breathing in the PICU
High Flow Nasal Cannula
Primary: Percent Change in Pressure-rate Product (PRP) as a Function of Increasing HFNC Flow Rate on Both Types of HFNC Delivery System (FP and VT) — -10; -20; -23 percent change…
N/A N=41 Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
Morbid Obesity · Noninvasive Ventilation · Deep Sedation
Primary: Ability to Maintain Oxygenation — 0.55; 0.61 manipulations
N/A N=87 Comparison of High Flow Nasal Cannula and Standard Face Mask Oxygen Therapy in Children With Bronchiolitis
Acute Bronchiolitis
Primary: Time Taken to Reach the Normal Range for Heart Rate (Per-protocol Analysis) — 12; 2 hour — p=<0.001
N/A N=18 The Impact of High-Flow Nasal Cannula on Swallow Function
Swallowing Disorder · Respiratory Insufficiency
Primary: Swallow Frequency Recorded by Surface Electromyography (sEMG) — 1.12; 1.13; 3.91; 1.01 number of swallows
N/A N=63 High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
Desaturation of Blood · Obesity · Colonoscopy
Primary: The Number of Desaturation Episodes — 0; 0 Episodes
N/A N=9 Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants
Obstructive Sleep Apnea
Primary: Average AHI Diagnostic Sleep Study Compared to Average AHI With Improvement in OSA With HFNC — 15.6; 5.12 events/hour
N/A N=51 Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
Post-operative Pulmonary Complications
Primary: Number of Participants With Post-operative Pulmonary Complications — 1; 2 Participants — p=0.680
N/A N=56 High Flow vs Conventional Oxygen in Head and Neck Surgery
Pulmonary Disease
Primary: Proportion of Patients With Post-operative Pulmonary Complication — 2; 11 Participants
N/A N=47 Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation
Acute Respiratory Failure · Treatment With Noninvasive Positive Pressure Ventilation
Primary: Length of Stay on Noninvasive Ventilation (NIV) — 1404; 1386 Minutes
N/A N=24 Evaluating High Flow Humidification Therapy in Patients With Cystic Fibrosis
Cystic Fibrosis
Primary: Change in Cystic Fibrosis Questionnaire-Revised (CFQ-R) — 0.056; 0.052; 0.192; 0.194 change in score on a scale
N/A N=175 THRIVE Use in Pediatric Populations- Multi Site
Oxygen Deficiency · Desaturation of Blood · Hypoventilation
Primary: Number of Participants With 4% Decrease From Baseline in Oxygen Desaturation Index — 18; 11; 13; 9 Participants — p=0.18
N/A N=37 Preoxygenation With Nasal Cannula and Noninvasive Positive Pressure Ventilation
Hypoxia
Primary: End-tidal Oxygen — 78.1; 78.6 End tidal oxygen saturation percentage
N/A N=26 The Effects of Different Flow Settings on Lung Impedance
Healthy
Primary: Change in End-expiratory Lung Impedance From Baseline Measured by Electrical Impedance Tomography (EIT) — 9; 74; 132; 7 Change in EELI (arbitrary units)
N/A N=78 Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Use in Pediatric Procedures
Oxygen Deficiency · Desaturation of Blood · Hypoventilation
Primary: Number of Surgical Interruptions — 0.645; 0.302 Interruptions — p=0.206
N/A N=228 High Flow Therapy for the Treatment of Respiratory Failure in the ED
Acute Respiratory Failure
Primary: Treatment Failure Rate — 13; 7; 87; 97 Participants
N/A N=30 Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients
Pulmonary Disease, Chronic Obstructive · Hypercapnia · Hypoxia
Primary: Use of Oxygen Therapy by HNHF-O2 at Home — 6.8 Hours
N/A N=26 Clinical Efficacy in Relief of Dyspnea by HVNI: Evaluation of New Cannulae Designs
Dyspnea · Hypercapnia · Respiratory Insufficiency
Primary: Patient Vital Signs -- Rated Perceived Dyspnea (RPD) — 3; 2.5; 2.5 units on a scale
Phase 2 N=19 High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients
Cancer
Primary: Change in Dyspnea Numeric Score Between 0 and 10 Minutes — -1.8; -1.8; -0.6; -0.5 score on a scale
N/A N=60 Nasopharyngeal Versus Nasal Cannula Oxygen Supplementation in Surgery Patients
Oxygen Administration During Deep Sedation
Primary: Number of Participants With Oxygen Saturations Below 92% — 3; 12 Participants
N/A N=500 The Performance of Two Oxygen Delivery Devices Used After General Anesthesia.
Hypoxemia
Primary: Number of Participants With Hypoxemia in Both Groups — 0; 0 number of participants
N/A N=108 Optiflow THRIVE for Delivery of Oxygen to Patients During Total Intravenous Anesthesia While Undergoing Radiology Procedures
Obstructive Sleep Apnea
Primary: Total Length of Desaturation Episodes (ToLDE) Per Patient/Surgical Procedure — 34; 97 minutes
Phase 4 N=64 Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation
Mechanical Ventilation Pressure High
Primary: Face Mask Leak Measured in Liters Per Minute by the Noninvasive Positive Pressure Ventilation Machine — 0; 0 Liters per minute
N/A N=55 External Nasal Dilator and Oxygen Therapy in Respiratory Failure
Acute Respiratory Failure
Primary: Change of Respiratory Status Using the Modified Bronchiolitis Severity Score, in Children Using External Nasal Dilators as an Adjuvant to High Flow Nasal Cannula Oxygen…
Phase 1 N=14 Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Infant Respiratory Distress Syndrome · Respiratory Insufficiency · Apnea of Prematurity
Primary: pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values — 50; 45 mm Hg — p=0.011
N/A N=6 Assessment of End Expiratory Lung Volumes in Healthy Subjects Using High Flow Oxygen (Vapotherm®)
Healthy Adult Volunteers
Primary: Change in End-expiratory Lung Volume — -144; 103 mL
N/A N=206 FiO2 Closed Loop Control Ventilation
Wounds and Injuries · Respiratory Failure
Primary: Relative Duration With Oxygen Saturation (SpO2) Within Target Range [Time Frame: 12 Hours] — 0.53; 0.61 arbitrary units
N/A N=34 Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
Unrecognized Condition
Primary: End Tidal Oxygen Fraction — 43.9; 81.9 percentage of End-Tidal Oxygen Fraction
N/A N=174 Comparison of Oxygenation and Ventilation With a Novel Nasal Mask Versus Standard of Care During Colonoscopy
Colonoscopy · Oxygenation · Ventilation
Primary: Time to First Intervention — 10; 19 minutes