N/A N=19 The Cardiovascular Effects of Electronic Hookah Vaping
Endothelial Dysfunction · Inflammation · Oxidative Stress
Primary: Flow-Mediated Dilation (FMD) — 6.11; 5.89; 4.79; 7.31 percentage of arterial diameter
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=507 A Study of Hookah Café Customers in the Atlanta Area
Waterpipe Tobacco Smoking
Primary: Change in Expired Carbon Monoxide (eCO Boost) — 25.7; 23.5 parts per million
N/A N=85 Assessing Toxicity of Waterpipe Tobacco Smoking
Waterpipe Smoking
Primary: Comparing Cotinine Pre-to-post Change Between 2 Waterpipe Smoking Sessions: Heating Waterpipe Tobacco by (a) Charcoal vs (b) an Electric Head — 34.9; 26.4 ng/mL — p=0.115
N/A N=54 Hookah Additive Research to Inform Product Standards
Tobacco-Related Carcinoma
Primary: Change in Exhaled Breath Carbon Monoxide (CO) — 80.1; 40.8; 62.5; 45.5 ppm
N/A N=2,589 Reactions to Warnings on Hookah Ads
Reactions to Warnings · Hookah Smoking
Primary: Emotional Reactions to Ads — 2.81; 3.46; 3.74; 2.83 score on a scale
N/A N=1,507 Consumer Perceptions of Waterpipe Tobacco Packaging and Digital Marketing Claims
Waterpipe Tobacco Smoking
Primary: Willingness to Try Hookah Tobacco (Packaging Task ) — 1.9; 1.87; 1.9; 1.63 score on a scale
N/A N=830 Optimizing Hookah Tobacco Public Education Messages to Reduce Young Adult Use
Hookah Tobacco Smoking
Primary: Hookah Tobacco Initiation — 11; 5 Participants
N/A N=40 Effect of Waterpipe Size on Smoking Behavior and Exposures
Waterpipe Size
Primary: Waterpipe Evaluation Scale — 4.2; 4.4; 4.7 units on a scale
N/A N=80 The Impact of Waterpipe Tobacco Flavors on Waterpipe Smoking Intentions, Perceptions, Patterns, and Toxicant Exposure
Smoking, Hookah · Waterpipe Smoking
Primary: Level of Smoke Inhalation Measured by Topography Device — 50.96; 77.79; 63.17; 51.60 Liters
N/A N=349 Optimizing Risk Messages for Waterpipe Tobacco Cessation in Young Adults
Hookah Smoking
Primary: Perceived Harm — 4.1; 4.2; 4.5 score on a scale
N/A N=1,215 Comparison of Text and Pictorial Waterpipe Tobacco Warnings Among Young Adults
Waterpipe Tobacco Smoking
Primary: Behavioral Intentions — 1.83; 1.72; 2.21 score on a scale
Phase 3 N=8 Vaping THC From Electronic Cigarettes
Marijuana Dependence
Primary: Mean Delivered and Retained Doses — 0.016; 0.018; 0.026 grams (g)
N/A N=10 IQOS (Non-Cigarette Tobacco Product) Pilot Study
Smoking · Tobacco Use
Primary: Number of Participants Who Prefer IQOS — 7 Participants
N/A N=139 Cigarette Smoking Among Young Adults
Cigarette Smoking · Smoking Behaviors
Primary: Puff Topography — 1108; 1045.2; 1084.6 mL
N/A N=60 Pharmacokinetic and Subjective Effects of Heated Tobacco Products
Tobacco Use
Primary: Baseline-adjusted Plasma Nicotine Concentration Pharmacokinetic (PK) Parameters [Cmax] Assessment — 6.426; 7.953; 8.288; 7.993 ng/mL
N/A N=25 Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products
Healthy Volunteers
Primary: Nicotine Cmax — 13.00; 12.97; 6.00; 6.87 ng/mL
N/A N=33 The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute
Tobacco Use
Primary: Percent Change in Average Daily Cigarette Use Per Day From Baseline — 36.8; 80.36 % reduction in cigarettes per day
N/A N=199 Perceptions of Cigarette Smoking in Young Adults
Smoking, Cigarette
Primary: Subjective Response to Smoking Cigarettes From the Cigarette Evaluation Scale — 4.68; 4.50 score on a scale — p=>.05
N/A N=40 Acute Effects of Cigarette Packaging and Charcoal Filtration on Perceptions, Use Behaviors, and Harm Exposure
Smoking Behaviors
Primary: Number of Puffs Taken (Video-scored Smoking Behavior Outcome 1) — 15.8; 16.7; 19.1; 19.6 puffs
N/A N=60 Smoking Topography and Harm Exposure in Menthol Cigarettes
Cigarette Smoking Toxicity
Primary: Smoking Topography- Puff Volume — 518; 661; 650; 620 mL
Phase 4 N=179 Smoking Tobacco and Drinking Study
Smoking · Heavy Episodic Drinking
Primary: Number of Participants With Reported 7-day Point Prevalence Abstinence at 3 Months — 3; 4 Participants
Phase 2 N=35 Comparison Between Marijuana Smoked in Cigarette Paper Versus Cigar Paper
Marijuana Dependence
Primary: Plasma THC — 6; 53; 70; 7 ng/mL
N/A N=103 Addiction and Behavior Related to Menthol Cigarette Substitutes
Smoking (Tobacco) Addiction
Primary: Puffing Topography: Puff Duration — 1.99; 2.06; 2.66; 1.87 seconds
N/A N=48 Nicotine Pharmacokinetic Profile of the CHTP 1.1 M
Smoking
Primary: Maximum Concentration (Cmax) of Nicotine Following Single Use of CHTP 1.1 M and mCC — 6.2950; 9.8463 ng/mL
N/A N=104 Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
Tobacco Use Disorder
Primary: Product Preference — 27; 23; 24; 24 participants
N/A N=22 Assessment of Two New Electronic Cigarettes in Cigarette Smokers
Electronic Cigarettes
Primary: Change in Plasma Nicotine — 7.62; 10.65; 18.31; 7.19 ng/ml
Phase 2 N=130 Health Effects of SLT, Cigarette Smoking, and New Tobacco Products
Nicotine Dependence
Primary: Toxicant Exposure by Products — 835.3; 782.1; 726.8; 0.157 ng/ml — p=0.002
N/A N=231 A Study to Evaluate Changes in Smokers Using Oral Tobacco-derived Nicotine Products.
Tobacco Use
Primary: Summary of Urine Total NNAL Amount Excreted and Absolute Change From Baseline (ng/24 Hour) by Study Group and Study Day (mITT Population) — 511.889; 581.676; 548.751…
N/A N=172 Effect of Switching From Cigarette Smoking to the Use of IQOS on Periodontitis Treatment Outcome
Periodontal Diseases · Chronic Periodontitis · Periodontal Pocket
Primary: Periodontal Pocket Depth (PD) Change From Baseline at 6 Months — -1.046; -1.114; -1.177 millimeters — p=0.297
N/A N=60 Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type
Cigarette Smoking · Nicotine Vaping
Primary: Nicotine/Tobacco Products Substitution — 12.11; 4.82; 25.28; 17.08 mg of nicotine purchased — p=0.9793