Phase 4 N=32 Angiotensin II in General Anesthesia
Hypertension
Primary: Median Dose Required to Increase the Systolic Blood Pressure (SBP) — 35; 43; 45 ng/kg/min
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=51 Methohexital v Propofol as General Anesthetic in Patients on ACEIs or ARBs
Hypotension · Anesthesia
Primary: Number of Participants Who Had Hypotensive Events — 8; 21 Participants — p=0.01
Phase 4 N=192 Impact of Propofol Reduction in Anesthesia Induction
Propofol Adverse Reaction · Anesthesia
Primary: Systolic Blood Pressure Variation — 26; 23; 18; 22 percentage of variation
N/A N=214 Hypotension Prediction Index for Blood Pressure Management
Intraoperative Hypotension
Primary: Time- Weighted Average (TWA) MAP Under a Threshold of 65 mmHg. — 0.14; 0.14 mmHg — p=0.757
N/A N=14 Blood Volume Analysis of Total Hip Arthroplasty Patients Under Hypotensive Anesthesia
Blood Volume Analysis
Primary: Change in Total Blood Volume — 487 ml
N/A N=60 Hemodynamic Responses During Induction: Comparison of Marsh and Schnider Pharmacokinetic Models
Healthy
Primary: SVI (Stroke Volume Index) Value Change From Baseline Level at the End of the First 25 Minutes. — -31.1; -31.7 ml/beat/m^2
N/A N=35 The Effect of Hypotensive Anesthesia on Hemoglobin Levels During Total Knee Arthroplasty
Anesthesia
Primary: The Hemoglobin (in g/dl) Levels — 12.2; 12.0; 11.9; 11.8 g/dl
Phase 4 N=80 Variable Rate Phenylephrine Infusion for Prevention of Spinal-induced Hypotension for Cesarean Delivery
Anesthetic Complication Spinal
Primary: Number of Physician Interventions Needed to Maintain Maternal Blood Pressure After Spinal Anesthesia Within 20% of Baseline and to Treat Bradycardia During Cesarean…
Phase 2 N=66 The Prevention of Hypotension After Epidural Analgesia After Major Surgery
Hypotension · Pain
Primary: Changes Between the 3 Groups Assessed by Blood Pressure Measurement — 5; 2; 3; 10 Participants — p=0.165
Phase 3 N=100 Analyzing the Relationship Between Speed Propofol is Given and Low Blood Pressure
Hypotension on Induction
Primary: Patients Administered Propofol at a Slower Rate of Infusion Will Have Lower Incidence of Post Induction Hypotension Than Patients Administered Propofol at FDA Approved…
Phase 4 N=82 Spinal Anesthesia Induced Hypotension During Cesarean Section
Hypotension
Primary: Incidence of Maternal Hypotension — 10.8; 27 percentage of participants
N/A N=72 Positive Pressure at Induction of Anesthesia in Children
Continuous Positive Airway Pressure · Hypoxia · General Anesthesia
Primary: Time Between Onset of Apnea and the Drop in 95% Oxyhemoglobin Saturation Levels — 227.65; 133.68 seconds — p=<0.0001
N/A N=110 Phenylephrine in Spinal Anesthesia in Preeclamptic Patients
Preeclampsia · Hypotension
Primary: The Umbilical Artery pH — 7.22; 7.20 pH — p=.38
N/A N=85 A Comparison of Ketofol (Ketamine and Propofol Admixture) Versus Propofol as Induction Agents on Hemodynamic Parameters
Blood Pressure
Primary: Percent of Subjects With a Greater Than 20% Decrease in Systolic Blood Pressure (SBP) Following Induction of General Anesthesia — 48; 12; 67; 39 Percentage of subjects…
Phase 4 N=3,626 Norepinephrine vs Phenylephrine During General Anesthesia
Anesthesia · Surgery · Hypotension
Primary: Number of Participants With Assigned Vasopressor Given — 1570; 1627 Participants
N/A N=65 Does Heart Rate Variablity (HRV) Predict Hypotension in Patients Undergoing Cervical Myelopathy Surgery ?
Heart Rate Variability
Primary: Heart Rate Variability (HRV) — 1439; 2191 ms2
N/A N=429 Predict Fluid Responsiveness in Spinal Anesthesia
Hypotension and Shock · Excessive Amount of Blood / Fluid Infusion
Primary: Percentage of Participants With Systemic Hypotensions — 68; 46; 65 Participants
N/A N=34 Hypotension Prediction Index to Predict Epidural-labor Analgesia Induced Hypotension
Anesthesia, Epidural · Hypotension
Primary: Time-to-treatment of Hypotension (Minutes) — 21.8; 23.1 minutes
N/A N=30 Cerebral Blood Flow During Propofol Anaesthesia
Gastrointestinal Neoplasms
Primary: Changes in Internal Carotid Artery Blood Flow by Treatment of Anaesthesia-induced Hypotension — 27 ml/min — p=0.0276
N/A N=17,463 Decision Support for Intraoperative Low Blood Pressure
Hypotension
Primary: Postoperative Acute Kidney Injury — 1333; 372; 9670; 2785 Participants
Phase 3 N=136 Midodrine for the Treatment of Refractory Hypotension
Hypotension · Critical Illness
Primary: Time Until Discontinuation of IV Vasopressors — 23.5; 22.5 hours
N/A N=102 Leg Elevation to Prevent Hypotension During Labor
Hypotension · Labor Complication
Primary: Number of Patients With Maternal Hypotension Requiring Treatment — 6; 11; 48; 27 Participants
N/A N=70 Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
Hypertension
Primary: Diastolic Blood Pressure Excursions Beyond Predetermined Lower Limits, Normalized Per Hour — 97.9; 45.6 mmHg*min/prebypass hour — p=0.21
Phase 4 N=75 Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia
Surgery
Primary: Blood Pressure — 105; 122; 117.88 mmHg
Phase 4 N=291 Chronic Angiotensin Converting Enzyme Inhibitors in Intermediate Risk Surgery
Hypotension on Induction
Primary: Number of Participants With Interoperative Hypotension — 76; 95 Participants — p=0.03
Phase 1 N=52 Nicardipine vs Esmolol Craniotomy Emergence
Brain Tumors
Primary: Failure of Drug to Control Systolic Blood Pressure (SBP) < 140 mmHg — 1; 11 participants
N/A N=40 Effect-site Concentration of Propofol for I-gel Insertion During Anesthesia Induction With a Single-dose Dexmedetomidine
Igel
Primary: Concentration of Propofol — 5.46; 3.82 ug/ml
Phase 4 N=178 Preventing Hypotension in Parturients With an Elevated Body Mass Index (BMI)
Hypotension
Primary: Incidence of Nausea and Vomiting — 59; 37 participants
Phase 4 N=337 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation
Acute Respiratory Failure · Intubation Complication
Primary: Number of Participants With Cardiovascular Collapse — 33; 31 Participants
Phase 2 N=47 Efficacy Study of a Facemask Device to Treat Hypotension
Hypotension
Primary: Rise in Systolic Blood Pressure Over the First 10 Minutes of Use Compared to Baseline — 5.9; 12.9 mm Hg