N/A N=22 Diagnosing Intensive Care Unit (ICU) Acquired Weakness
ICU Acquired Weakness
Primary: Peak Acceleration Measured in Extensor Carpi Radialis Longus — 0.476; 1.639; 0.541; 1.608 units of Gravity
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=34 Use of Neuromuscular Electrostimulation (NMES) for Treatment or Prevention of ICU-Associated Weakness
Intensive Care Unit · Muscle Weakness
Primary: Lower Extremity Strength, at Hospital Discharge, of 3 Bilateral Muscle Groups (Pretibial, Triceps Surae, and Quadriceps) Measured Via MMT Using a Composite Medical…
N/A N=120 Treatment of Critical Illness Polyneuromyopathy
Acute Respiratory Failure
Primary: The Primary Outcome Variable for This Study Will be the Short Form of the Continuous Scale Physical Functional Performance Test (CS-PFP) Called the PFP-10 — 19.0; 20.9…
N/A N=9 Neurosciences-Intensive Care Unit Electrical Stimulation
Intensive Care (ICU) Myopathy
Primary: Duration of Intubation — 10.22 days
Phase 1 N=19 Electrical Stimulation for Critically Ill Covid-19 Patients
Covid19 · Muscle Atrophy · Muscle Weakness
Primary: Change in Gastrocnemius Muscle Endurance (Muscle Sustained Contraction) in Response to Electrical Stimulation — 352; 323 milliVolts
Phase 2 N=19 Electrical Stimulation for Critically Ill Post-Covid-19 Patients
COVID-19 · Muscle Atrophy · Muscle Weakness
Primary: Gastrocnemius Muscle Endurance (Muscle Sustained Contraction) in Response to Electrical Stimulation — 363.04; 359.55 miliVolts
N/A N=232 Vanderbilt ICU Recovery Program Pilot Trial
Intensive Care Unit Syndrome · Intensive Care Neurological Disorder · Intensive Care (ICU) Myopathy
Primary: Number of Components of the ICU Recovery Program Received — 2; 1 interventions
N/A N=153 Improving the Recovery and Outcome Every Day After the ICU
Delirium · Alzheimer Disease
Primary: Cognitive Status Outcome at 6 Months — 0.24; 0.36; 0.21; 0.35 Z-score — p=0.747
N/A N=73 Effect of EPA and HMB on Strength in ICU Patients
Muscle Weakness
Primary: Change of Skeletal Muscle Strength for One of the Drugs Compared to Placebo — 1.3; 0.1; 1.5; 0.7 cm H2O
N/A N=20 Preventing the Loss of Muscle and Function in Hospitalized Older Adults
Muscular Atrophy
Primary: The Percent Change in Bilateral Thigh Lean Mass Density (Grams) as Measured by DEXA Scan Will be Compared Between Baseline and After 5-days of Bed Rest — -3.845; -0.249…
N/A N=33 Development of a Rehabilitation Strengthening and Mobility Program for Ventilator Dependent Older Patients
Respiration, Artificial · Critical Illness · Chronic Disease
Primary: Functional Assessment: Handgrip — 3.6; 1.3 kg
N/A N=7 A Randomized, Controlled Trial of Inspiratory Muscle Training (IMT)in the ICU and CCU
Critically Ill · Respiratory Failure
Primary: Safety and Feasibility of Inspiratory Muscle Training — 3; 3 Participants
Phase 2 N=18 Early Insulin and Development of ARDS
Respiratory Distress Syndrome, Adult · Sepsis · Hyperglycemia
Primary: Plasma Levels of Free Fatty Acids, Tumor Necrosis Factor-α, Interleukin-6, and Von Willebrand Factor Antigen
N/A N=53 Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
Respiratory Failure
Primary: Level of Activity of Daily Life — 25.2; 32.0 units on a scale — p=0.652
N/A N=252 Impact on Mental, Physical, And Cognitive Functioning of a Critical Care sTay During the COVID-19 Pandemic
Covid19 · Critical Care · Postintensive Care Syndrome
Primary: World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) — 5; 13.5 units on a scale
Phase 3 N=1,008 Reevaluation Of Systemic Early Neuromuscular Blockade
Acute Respiratory Distress Syndrome
Primary: Hospital Mortality to Day 90 — 288; 289; 213; 216 Participants — p=0.93
N/A N=100 High Protein, Core Muscle Rehab, Muscular Electrostimulation in Prolonged Mechanical Ventilation
Prolonged Mechanical Ventilation · Protein Deficiency
Primary: Weaning Rate — 3; 20; 22; 26 Participants
N/A N=73 Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
Sepsis
Primary: Delta Curve Between Calculated GFR and GFR Measured by Iohexol at Baseline — 91.5; 88.3; 93.6; 90.0 ml/min/1.73m2 — p=<0.05
Phase 4 N=302 Residual Curarization and Its Incidence at Tracheal Extubation (P08194)
Observation of Neuromuscular Block
Primary: Percentage of Participants With Residual Neuromuscular Blockade (NMB)(Train of Four [TOF] Ratio <0.9) at Time of Tracheal Extubation — 56 percentage of participants
N/A N=30 Predictors of the Ability to Protect the Airway in Long-term Ventilated Patients
Swallowing Disorder · Aspiration · Long Term Ventilation
Primary: Muscle Strength — 20; 10 participants
N/A N=24 A Study Promoting Critical Illness Recovery in the Elderly
Acute Respiratory Distress Syndrome · Critical Illness · Critical Care
Primary: Number of Patients in the Intervention Arm Who Are Able to Undergo a Cycling Session — 13; 0 Participants
N/A N=82 Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock
Septic Shock · Fluid Therapy · Hypotension
Primary: Cumulative Fluid Administered — 4417; 4110 mL of study fluid
N/A N=83 Feasibility, Acceptability, and Barriers to Implementation of a Geriatrics Bundle in the ICU
Intensive Care Unit Syndrome
Primary: Feasibility of Bundle Delivery — 50 Participants
N/A N=350 Incidence of Incomplete Postoperative Neuromuscular Recovery From Anesthesia (P07535)(Completed)
Neuromuscular Blockade
Primary: Number of Participants With Train-of-four (TOF) Ratio <0.9 at PACU Arrival — 91 participants
N/A N=159 Decreasing Delirium Through Music in Critically Ill Older Adults
Intensive Care Unit Delirium · Pain · Anxiety
Primary: Days Free of Delirium and Coma — 2.5; 3 Delirium/coma-free days by day 7 — p=0.775
N/A N=677 Unexpected Cardiac Arrest in Intensive Care Unit
Heart Arrest
Primary: Number of Patients With Unexpected Cardiac Arrest — 677; 30,722 Participants
Phase 3 N=305 Impact of SPN on Infection Rate, Duration of Mechanical Ventilation & Rehabilitation in ICU Patients
Critically Ill
Primary: Documented Infection Rate — 58; 41 Infections
Phase 3 N=274 Hypovitaminosis D in Neurocritical Patients
Craniocerebral Trauma · Intracranial Aneurysm · Brain Neoplasms
Primary: Intent-to-treat Hospital Length-of-stay — 10.9; 9.1 days — p=0.2
N/A N=15 Acupuncture for Sedation in the Intensive Care Unit (ICU)
Delirium · Respiratory Depression · Overmedication
Primary: Success of Blinding — 1; 1 Participants
Phase 2 N=83 Neuromuscular Blockade for Post-Cardiac Arrest Care
Cardiac Arrest
Primary: Change in Lactate Over 24 Hours — -2.2; -2.3 mmol/L