N/A N=928 Little Cigar and Cigarillo Warnings for Youth
Little Cigars and Cigarillos (LCC) Use
Primary: Willingness to Use Little Cigars Cigarillos (LCCs) — 2.86; 3.08; 2.99 score on a scale
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=1,029 Little Cigar and Cigarillo Warnings Among US Adults Who Use LCCs
Tobacco Use
Primary: LCC Quit Intentions — 2.9; 2.49; 2.54 score on a scale
N/A N=65 Addictive Potential of LCCs in Dual Users
Tobacco Use Disorder · Dual Tobacco Use · Tobacco Dependence
Primary: Demand Elasticity — 0.027; 0.032 cigarettes/dollar
N/A N=1,578 The Impact of Cigarillo Warnings on Purchasing
Cigar Smoking
Primary: Average Total Number of Cigarillos Purchased — 6.33; 6.28; 6.64; 4.98 cigarillos
N/A N=103 Addiction and Behavior Related to Menthol Cigarette Substitutes
Smoking (Tobacco) Addiction
Primary: Puffing Topography: Puff Duration — 1.99; 2.06; 2.66; 1.87 seconds
N/A N=24 User Acceptability of a Nicotine Lactate Delivery System (P3L)
Smoking
Primary: Change From Baseline Plasma Concentration of Nicotine/Cotinine After Each ad Libitum Use Session. — 1.7621; 2.4113; 1.9446; 5.5571 (ng/mL)
Early Phase 1 N=95 The Effect of Sweet Flavoring on the Rewarding and Reinforcing Value of Cigarillo Use Among Young Adults
Tobacco Use · Cigar Smoking
Primary: Subjective Rewarding Value of Cigarillo Flavoring — 4.03; 3.63; 3.30 score on a scale
N/A N=136 Reduced Nicotine Content Cigarettes and Tobacco Switching Behaviors
Tobacco Addiction · Dual Tobacco Use
Primary: Number of Days Using Alternative Products — 14; 26; 20 Number of days
N/A N=139 Cigarette Smoking Among Young Adults
Cigarette Smoking · Smoking Behaviors
Primary: Puff Topography — 1108; 1045.2; 1084.6 mL
N/A N=80 Low Nicotine Cigarettes Plus Electronic Cigarettes
Tobacco Dependence
Primary: Urinary NNAL (4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol) — 505.6; 459.1; 373.3; 180.5 pg/mg creatinine — p=0.017
N/A N=31 Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Smoking
Primary: Breath Sample (Expired Carbon Monoxide) — 18.77; 31.07; 25.38; 30.49 parts per million — p=0.92
N/A N=764 Cigarillo Warnings Image Sorting Study
Smoking, Cigar
Primary: Intention to Quit Smoking Cigarillos in the Next 30 Days at Weeks 2-4 — 2.47; 2.49; 2.34; 2.44 units on a scale
N/A N=37 Menthol Flavored E-cigarette Use During a Simulated Ban of Menthol Cigarettes
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 2.2; 1.8; 6.0; 7.1 model estimated cigarettes per day
Phase 3 N=438 Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace
Tobacco Smoking · Nicotine Dependence
Primary: Cigarettes Per Day (CPD) — 7.05; 12.95 cigarettes per day
Phase 2 N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day
N/A N=267 Testing Legally Feasible Options: Study 1
Tobacco Use
Primary: Proportion of Participants Susceptible to Smoking Cigarettes After Shopping in the StoreLab (Non-flavored) — .18; .23; .33 proportion of participants
N/A N=47 Effect of Banning Menthol Flavorant on Cigarette and E-Cigarette Use
Tobacco Use Disorder
Primary: Amount of Tobacco Product Used — 13.1; 18.6; 15.3; 56.7 tobacco products use per day — p=0.349
N/A N=1,132 Correcting Public Misperceptions About Very Low Nicotine Content Cigarettes
Tobacco Use, Cigarette Use
Primary: Very Low Nicotine Content (VLNC) Misperception — 3.12; 3.04; 3.04; 3.36 score on a scale
N/A N=50 Assisting Smokers to Switch to a JUUL E-Cigarette by Devaluing Combustible Cigarettes
Smoking Cessation · Harm Reduction · E-Cig Use
Primary: Effects of Devaluation on Switching From Cigarettes to the JUUL E-cigarette — 4; 4 Participants
Phase 2 N=130 Health Effects of SLT, Cigarette Smoking, and New Tobacco Products
Nicotine Dependence
Primary: Toxicant Exposure by Products — 835.3; 782.1; 726.8; 0.157 ng/ml — p=0.002
Phase 3 N=81 Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction
Tobacco Dependence
Primary: Tobacco Abstinence at 12 Weeks — 8; 5 participants
N/A N=33 The Abuse Liability of a Novel Heated Tobacco Product (IQOS) and Its Feasibility as a Menthol Cigarette Substitute
Tobacco Use
Primary: Percent Change in Average Daily Cigarette Use Per Day From Baseline — 36.8; 80.36 % reduction in cigarettes per day
N/A N=187 Effects Among Smokers Who Use and Do Not Use E-Cigarettes
Toxicant Exposure
Primary: Toxicant Exposure — 40; 97 pg/ml
N/A N=40 Acute Effects of Cigarette Packaging and Charcoal Filtration on Perceptions, Use Behaviors, and Harm Exposure
Smoking Behaviors
Primary: Number of Puffs Taken (Video-scored Smoking Behavior Outcome 1) — 15.8; 16.7; 19.1; 19.6 puffs
N/A N=305 Abuse Liability of Reduced Nicotine Content Cigarettes Within a Complex Tobacco Marketplace
Substance-Related Disorders
Primary: Estimated Cigarettes Taken at Free Price Derived From the Cigarette Purchase Task — 1.50; 1.45; 1.47; 1.45 Cigarettes (log transformed)
N/A N=213 Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers
Cigarette Smoking-Related Carcinoma · Tobacco-Related Carcinoma
Primary: Usual Brand Cigarettes Per Day — 15.803; 2.1563; 1.8353; 1.4931 Cigarettes per Day
N/A N=52 Menthol and Mint Experimental Tobacco Marketplace (ETM) Study
Cigarette Smoking · Vaping
Primary: Total Amount of Combusted Tobacco Purchased — 990.6 mg
Phase 2 N=49 Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco
Nicotine Dependence, Cigarettes, Uncomplicated
Primary: Average Cigarettes Smoked Per Day — 4.3; 8.0 average cigarettes per day — p=.111
N/A N=104 Evaluation of Oral Tobacco as a Harm Reduction Method for Smokers
Tobacco Use Disorder
Primary: Product Preference — 27; 23; 24; 24 participants
N/A N=326 Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age
Tobacco Use Disorder
Primary: Number of Cigarettes Smoked Per Day — 22.54; 14.32; 11.76; 7.63 cigarettes per day