Clinical Trial Search

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Alzheimer's Disease Cooperative Study- Clinical Global Impression Change (ADCS-CGIC) — 3.92; 3.48 scores on the CGIC

Primary: Percentage of Recruited Subjects Able to Comply With the Protocol — 12; 13; 3; 14 Participants

Primary: Quality of Life in Alzheimer's Disease (QOL-AD)--Participants With Dementia (PWD) — 35.42; 38.10; 35.56; 36.12 score on a scale

Primary: Change in Alzheimer's Disease Assessment Scale-cognitive Subscale (ADAS-cog) — 2.83 score on a scale — p=0.002

Primary: Stroop Test Performance From Pre- to Post-intervention — 137.67; 56.17; 116.51; 55.13 Time to complete (seconds)

Primary: Change in Score on the Rey Auditory Verbal Learning Test (RAVLT) — 13.8; 17.8; 18.0; 13.4 T-score on a scale — p=0.25

Primary: ADAS-Cog-Exec Global Composite — -0.146; -0.068 Change score — p=0.29

Primary: Change in Baseline Burden and Stress of Caregivers Over 3 Months — -52.0; -31.9 percentage change

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: Mean Change in Cognitive Function — -0.6960; -0.6095; 0.6018; 0.6018 z-score

Primary: Change in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score From Baseline — 1.1; .9 score on a scale

Primary: Rate of Change of Hippocampal Volume Slope — -70.2418748; -88.4738591; -94.0768115; -46.9484805 mm^3/year — p=0.095

Primary: California Verbal Learning Test II — 6.9; 6.2; 6.46; 5.10 units on a scale — p=0.048

Primary: Dyad Congruence With Goals-of-Care Tool — 9; 4; 11; 24 Participants

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: 12-Month Cumulative Incidence of ADRD Diagnoses — 213; 134; 355 Number of new ADRD cases — p=0.006

Primary: Success Rate of Adherence — 2; 6; 7 Participants — p=0.12

Primary: Change in Global Cognitive Function as Assessed by the Wechsler Memory Scale-III — -0.2; -0.2 score on a scale

Primary: Change in Cognitive Performance — 0.8; 0.7; 1.2; 0.4 units on a scale — p=<0.0125

Primary: Change in Objective Cognitive Performance Composite z Score — .24; .14 Z score

Primary: Auditory Memory Attention Index — 89.0; 94.3 standard score units — p=<0.01

Primary: Hopkins Verbal Learning Test-Revised (HVLT-R) — 23.52; 20.04; 23.68; 20.39 score on a scale

Primary: Total Number of Words Correctly Recalled, List Learning, California Verbal Learning Test-II, Assessed 1 Week After Intervention and Adjusted for Baseline Performance…

Primary: Change in Quality of Life-Alzheimer's Disease Score — 12.32; 15.88 score on a scale

Primary: Imaging Biomarkers FDG-PET SUVR in Regions of Interest — -0.048; -0.005; -0.032; -0.007 Standardized Uptake Value Ratios (SUVRs)

Primary: One-card Learning (OCL) Measurement Over 12 Weeks of Treatment — 0.954; 0.942; 0.822; 0.969 Score on a scale

Primary: Rey Auditory Verbal Learning Test (Total Delayed Recall) — 6.43; 7.83 score on a scale — p=0.11

Primary: The Primary Outcome Measure is the Number of Subjects in Each Group Who Are Able to Pass the DriveABLE On-Road Test at Month 12 (Endpoint). — 13; 10; 13; 9 participants

Primary: Link Between Lack of Word and Presbycusis — 38; 38.5; 23; 21.5 score on a scale