Phase 1 N=62 Muscle Perfusion and Protein Metabolism in Elderly
Aging
Primary: Mixed Muscle Fractional Synthesis Rate (FSR) — 0.061; 0.070; 0.066; 0.070 Fractional Synthesis Rate (pecent/hour)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=61 Muscle Growth Following a Resistance Training Program in Men and Women Consuming Protein Supplements
Skeletal Muscle Growth
Primary: Lean Body Mass Change — 1.5; 1.3 kilogram — p=<0.05
N/A N=16 Effect of an EAA/Whey Composition on Protein Metabolism
Sarcopenia
Primary: Protein Anabolism — 3.56; 11.8; 3.02 grams — p=<0.05
N/A N=40 Muscle Mass During Space Exploration
Muscle Loss
Primary: Lean Leg Mass — -1.2; -0.9 g
N/A N=16 Effect of Exercise on the Human Skeletal Muscle Phosphoproteome
Skeletal Muscle Protein Synthesis
Primary: Change in Acute Muscle Protein Synthesis — 143; 123 percent change
N/A N=8 Whole Body Protein Metabolism of a Whey/EAA Supplement Using Continuous Oral Stable Isotopes
Healthy
Primary: Whole-body Protein Net Balance — 6.2; 11.8 grams
N/A N=20 Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Muscle Protein Synthesis · Whole-body Protein Balance
Primary: Postprandial, Resting Muscle Protein Synthesis Rates — 0.055; 0.061 percent per hour
N/A N=80 Effect of Whey Protein Supplementation and Resistance Exercise on Muscle Parameters in Older Adults
Mobility Limitation
Primary: 1 Repetition Maximum Muscle Strength 1-RM (N) Double Leg Press — 1223; 1256; 1483; 1465 N
N/A N=141 Impact of Protein and Alkali Supplementation on Skeletal Muscle in Older Adults
Age-Related Sarcopenia · Muscle Loss
Primary: Double Leg Press Peak Power at 70% — 260.3; 255.6; 251.1; 264.8 Watts
N/A N=37 Forearm Immobilization, Metabolic Health, and Muscle Loss
Healthy
Primary: Percent Change in Forearm Glucose Uptake — -73; 127; -95 Percent change in clamp FGU with immob
N/A N=33 Role of the Protein Matrix in the Anabolic Response to a Ground Beef Patty as Opposed to the Impossible (Vegi-) Burger
Protein Metabolism
Primary: Postprandial Plasma Essential Amino Acid Concentration Incremental Area-under-the-curve [ Time Frame: 360 Minutes] — 117896; 75098; 94058 micromoles per liter per minute
N/A N=40 Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation
Osteoarthritis
Primary: Stair Time up — 7; 8 seconds
N/A N=20 Preventing the Loss of Muscle and Function in Hospitalized Older Adults
Muscular Atrophy
Primary: The Percent Change in Bilateral Thigh Lean Mass Density (Grams) as Measured by DEXA Scan Will be Compared Between Baseline and After 5-days of Bed Rest — -3.845; -0.249…
N/A N=22 Regulation of Muscle Protein Phenotype in Humans With Obesity
Obesity
Primary: Whole-Muscle Protein Synthesis — 0.004; 0.015 %/hr
N/A N=15 Effect of Caloric Restriction and Protein Intake on Metabolism and Anabolic Sensitivity
Weight Loss · Starvation
Primary: Change in Resting Metabolic Rate — -63.4; -77.6; -47.4 kcal change
N/A N=44 Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
Sarcopenia
Primary: Whole Body Protein Turnover — -0.16; -0.17; 0.48 g/kg lean body mass/day
N/A N=30 Nutritional Biomarkers of Sarcopenia
Sarcopenia
Primary: Resting and Maximum Plasma Leucine Concentration — 659; 755; 721; 95 micromoles per liter
N/A N=9 Translational Control of Anabolic Resistance in Aging Muscle
Physical Inactivity
Primary: Lean Mass — 403 grams
N/A N=13 (KIWI) Speeding up a Slow Protein for Muscle Mass With Hay Kiwifruit
Metabolism · Protein
Primary: Whole Body Net Balance Measured by Gas Chromatography-Mass Spectrometry (GC-MS) — 14.58; 14.55 g protein per 300 mins
Phase 2 N=56 Milk Protein Feeding After Aerobic Exercise in Older Adults With Pre-diabetes Taking the Biguanide Metformin
Physical Activity
Primary: Mitochondrial Function — 7.1; 43.2; 15.6; 13.8 percent change in pmol/s/mg tissue
N/A N=12 Impact of Muscle Temperature on Muscle Growth and Breakdown: Cooling During Resistance Training
Exercise Training
Primary: RT-qPCR for Forkhead Box O3 (FOXO3a) — 1.24; 1.30 fold change — p=.609
N/A N=105 Protein Supplementation in Elderly With Sarcopenic Obesity Undergoing Caloric Restriction and Exercise
Sarcopenic Obesity · Aging
Primary: Percentage of Fat-free Mass — 49.6; 50.3; 50.5; 52.5 percentage of fat-free mass — p=0.013
Phase 4 N=29 Anabolic and Inflammatory Responses to Short-Term Testosterone Administration in Older Men
Sarcopenia
Primary: Serum Total Testosterone Measured Before Treatment on Treatment Day 1 (Baseline Study) — 307.57; 363.43; 408.17; 318.68 ng/dL
N/A N=68 Blood Flow, Muscle Regeneration and Sarcopenia
Sarcopenia
Primary: Muscle Satellite Cells — 3.2; 3.2; 4.0; 3.8 Number of Pax7+ cells/muscle fiber
N/A N=24 Metabolic Effect of High-protein Meals in Men
Healthy
Primary: Post-prandial Plasma Responses of Glucose Concentrations — 136.5; 121.2; 102.9; 160.3 mmole/L*min
N/A N=58 Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
Insulin Resistance · Obesity
Primary: Change in Muscle Strength — 0.37; -0.2 Ratio
N/A N=12 Inflammation and Protein Restriction
Protein Restriction · Diet · Inflammation
Primary: Changes in the Human Intestinal Microbiome That Result From Short Term Dietary Adjustment. — 232; 172; 145; 93 Number of immunity related genes — p=0.05
Phase 3 N=28 Carnitine Supplementation and Skeletal Muscle Function
Sarcopenia
Primary: Blood Inflammatory Marker — 2.6; 1.8; 2.9; 1.7 mg·L^-1
N/A N=12 Optimizing Protein Patterns for Skeletal Muscle Preservation and Sleep in the Medical Management of Parkinson Disease
Parkinson Disease
Primary: Change in Markers of Skeletal Muscle Metabolism GDF15
N/A N=38 Training Induced Muscle Exosome Release
Metabolism
Primary: miR-1 Abundance — 226; 110; 286 percent change