Phase 4 N=30 Peripheral Nerve Blocks for Above-the-knee Amputations
Peripheral Vascular Diseases · Hyperglycaemia (Diabetic) · Hypertension
Primary: Peripheral Nerve Block Success as a Primary Anesthetic — 1 Participants
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N/A N=80 Saphenous Nerve Block for Foot and Ankle Surgery
Saphenous Nerve Block
Primary: Block Success — 18; 22 participants — p=0.25
N/A N=49 Pudendal Nerve Block for Hemorrhoidectomy
Hemorrhoids · Postoperative Pain
Primary: Postoperative Pain on the Visual Analogue Scale (VAS) — 1.4; 3.1 units on a scale
N/A N=16 Thermal-Imaging Comparison of Nerve Blocks for Bilateral Mastectomy
Anesthesia, Conduction
Primary: Skin Temperature Increase From Baseline — 1.9; 2.3 degrees C
Phase 4 N=44 Surgeon Infiltration QL Block Comparison
Quadratus Lumborum Block · Surgical Wound Infiltration
Primary: Opioid Consumption in Oral Morphine Milliequivalents for the First 24 Hours After Surgery (Defined as 24 Hours After the Anesthesia End Time) — 17.50; 21.25 oral…
Phase 4 N=52 Ultrasound Guided Distal Peripheral Nerve Blocks and Postoperative Pain.
Postoperative Pain
Primary: Proportion of Patients Who Experienced Moderate to Severe Pain During First and Second Postoperative Day — 8.3; 80.8; 4.2; 42.3 percentage of patients
N/A N=32 Evaluation of Continuous Saphenous Nerve Block to Supplement a Continuous Sciatic Nerve Block After Ankle Surgery
Orthopedic Surgery of Lower Extremity
Primary: Verbal Pain Scores — 4.2; 5.4 units on a scale
N/A N=60 Saphenous Nerve Block vs. Femoral Nerve Block for Total Knee Arthroplasty
Difference Between Femoral Nerve Block and Saphenous Block
Primary: Visual Analogue Scale Pain Score — 2.81; 2.47 units on a scale
Phase 4 N=80 Analgesia After Total Shoulder Arthroplasty
Total Shoulder Arthroplasty
Primary: Numeric Rating Scale (NRS) Pain Score With Movement — 4.5; 3.4; 4.2; 4.9 units on a scale
Phase 4 N=24 Continuous Adductor Canal Nerve Blocks: Relative Effects of a Basal Infusion v. Hourly Bolus Doses
Healthy Human Volunteers
Primary: Tolerance to Cutaneous Electrical Current — 26.6; 27.1 mA
N/A N=94 Saphenous Nerve Block Versus Femoral Nerve Block for Total Knee Arthroplasty
Total Knee Arthroplasty
Primary: Quadriceps Muscle Strength — 7.3; 2.2 kilogram-force
Phase 4 N=165 Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty
Primary: Maximum Pain Post-Operative Day (POD) 1 (Morning) — 3; 4; 4.5 units on a scale — p=0.144
Phase 4 N=119 Pectoralis Block vs Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Recovery Room Numeric Rating Scale Pain Scores — 3.3; 1.3 score on a scale
Phase 4 N=100 Single Shot Versus OnQ Pump in Extremity Fractures
Pain · Fracture
Primary: Change in Score on Visual Analog Scale (VAS) — 3.28; 1.47; 3.62; 3.91 score on a scale
N/A N=72 Pudendal Nerve Block in Vaginal Surgery
Nerve Block · Pain, Postoperative · Pelvic Floor Disorders
Primary: Visual Analog Scores at 7am After Surgery — 29.2; 42.6 score on a scale
Phase 4 N=60 Ultrasound Guided Trigeminal Nerve Block for Typical or Atypical Facial Pain
Typical Facial Pain · Atypical Facial Pain
Primary: The Proportion of Subjects Reporting at Least 50% Overall Pain Relief — 19; 14; 10; 16 Participants — p=.196
Early Phase 1 N=50 IV Steroids Versus Steroids Included in Block for Orthopedic Lower Limb Surgery
Lower Limb Injury
Primary: Analgesia Duration — 22.1; 25.7 Hours
Phase 2 N=192 Periarticular Injection Versus Peripheral Nerve Block in Total Hip Arthroplasty
Hip Arthropathy
Primary: Daily Opioid Consumption — 29.3; 30.8; 49.6; 51.8 milligram — p=0.69
Phase 4 N=85 Perineural Steroids for Peripheral Nerve Blocks
Osteoarthritis, Knee
Primary: Duration of Sensory Nerve Block — 37.00; 31.75; 29.67 hours
Phase 3 N=103 Ultrasound Guided Supraclavicular Nerve Block
Local Anesthetic
Primary: Duration of Analgesia. — 7.5; 10 minute — p=0.14
N/A N=30 A Comparison of Postoperative Analgesic Nerve Block Ropivacaine Concentrations
Total Hip Arthroplasty · Postoperative Pain
Primary: Opiate Consumption Postoperatively — 8.21; 8.02 mg
Phase 4 N=100 Serratus Plane Versus Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Mean/Median Numeric Rating Scale Pain Score Within the Recovery Room — 4; 0 score on a scale — p=0.001
Phase 4 N=84 Hip Scope Fascia-iliaca (FI) Block Study
Hip Dysplasia · Femoroacetabular Impingement · Acetabular Labrum Tear
Primary: Visual Analog Scale — 2.65; 2.50 units on a scale
N/A N=80 Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
Posterior Knee Infiltration
Primary: Pain Intensity — 3.5; 3.2; 2.1; 1.5 pain score
Phase 4 N=60 Comparison of Obturator Nerve Blockade and Neuromuscular Blockade
Cancer of Bladder
Primary: Number of Patients With Incidence of Intraoperative Adductor Spasm — 1; 5 Participants
Phase 4 N=24 Optimizing Local Anesthetic Concentration for Continuous Popliteal-Sciatic Nerve Blocks
Relatively Healthy Volunteers
Primary: Maximum Tolerance to Transcutaneous Electrical Stimulation — 27.0; 26.9 mA (milliamperes) — p=0.02
Phase 4 N=99 Greater Occipital Nerve Block Versus Metoclopramide
Migraine
Primary: 0-10 Pain Score — 5.0; 6.1 units on a scale
Phase 4 N=100 Erector Spinae Versus Paravertebral Nerve Blocks for Breast Surgery
Breast Surgery
Primary: Numeric Rating Scale Pain Scores — 3.0; 0 score on a scale — p=0.0011
Phase 2 N=243 Phase 2B Upper Extremity Nerve Block Study
Postoperative Pain
Primary: Mean Area Under the Curve (AUC) of the Numeric Rating Scale (NRS) Pain Intensity Scores With Activity (NRS-A) Through 24 Hours Postsurgery (AUC0-24). — 124.51; 136.17…
Phase 4 N=115 Systemic Steroids for Peripheral Nerve Blocks
Osteoarthritis, Hip
Primary: Duration of Sensory Blockade — 18.5; 18.1; 19.6 hours