N/A N=40 Nasal Noninvasive NAVA in the Very Low Birth Weight Infant
Inadequate; Pulmonary Ventilation, Newborn · Infant, Very Low Birth Weight
Primary: Change in Partial Pressure of Carbon Dioxide on Capillary Blood Gas — 0.019 mm Hg
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 3 N=16 Physiologic Comparison Between NIV-NAVA and PS in Preterm Infants
Noninvasive Neurally Adjusted Ventilatory Assist and Pressure Support in Preterm Infants
Primary: Trigger Delay — 35.2; 294.6 ms — p=<0.001
Phase 2 N=24 Randomized Crossover Study of Neurally Adjusted Ventilatory Assist (NAVA) in Preterm Infants
Infant, Preterm
Primary: Peak Inspiratory Pressure — 13.45; 12.45 cmH2O — p=0.043
N/A N=19 A Comparison of Non-invasive Ventilation Methods Used to Prevent Endotracheal Intubation Due to Apnea in Very Low Birth Weight Infants
Apnea of Prematurity
Primary: Number of Participants Who Were Intubated — 6; 8 Participants
N/A N=34 Study of Nasal Ventilation In Preterm Infants To Decrease Time on The Respirator
Bronchopulmonary Dysplasia
Primary: Number of Days Being Intubated — 12.4; 6.2 days
N/A N=22 Randomized Crossover of NAVA and Synchronized Intermittent Pressure Ventilation in Neonates and Infants
Respiratory Insufficiency · Infant, Newborn, Disease
Primary: Respiratory Severity Score (MAP X FiO2) — 3.83; 3.82; 3.46; 3.86 score on a scale
N/A N=1,493 A Trial Comparing Noninvasive Ventilation Strategies in Preterm Infants Following Extubation
Intubated Infants Were Intend to Extubation Using Noninvasive Ventilation Strategies
Primary: Duration of Invasive Mechanical Ventilation — 6.3; 7.8; 7.3 day
N/A N=200 Trial of Non Invasive Ventilation for Respiratoy Distress Syndrome
Prematurity · Respiratory Distress Syndrome
Primary: Need for Endotracheal Ventilation in the First 72 hs of Life — 34; 25 participants — p=<0.05
N/A N=80 Effective Approaches & Strategies to Ease Off Nasal CPAP In Preterm Infants
Neonatal Respiratory Distress Syndrome · Extremely Low Birth Weight Infant (ELBW) · BronchoPulmonary Dysplasia
Primary: Number of Participants With Successful Wean Off CPAP at the First Attempt — 31; 30 Participants
Phase 1 N=14 Nasal High Frequency Ventilation in Preterm Infants: A Pilot Study
Infant Respiratory Distress Syndrome · Respiratory Insufficiency · Apnea of Prematurity
Primary: pCO2 Measurements Post-intervention, as Compared to Pre-intervention Values — 50; 45 mm Hg — p=0.011
N/A N=340 NHFOV vs. NCPAP as a Primary Treatment to Neonatal Respiratory Distress Syndrome(NRDS)
Preterm Infants
Primary: Number of Participants Who Required Intubation — 26; 15 Participants
N/A N=19 Non-invasive Intervention for Apnea of Prematurity
Apnea of Prematurity · Hypoxia · Bradycardia
Primary: Change in Total Number of Episodes of Apnea/Breathing Pauses During Intervention and Without Intervention — 284.13; 174.27 breathing pauses
N/A N=66 A Comparison of Methods of Discontinuing Nasal CPAP in Premature Infants <30 Weeks Gestation
Apnea of Prematurity · Respiratory Distress Syndrome
Primary: Number of Days on NCPAP or Mechanical Ventilation — 17.3; 12.3 days
N/A N=7 Effect of Nasal Continuous Positive Airway Pressure on The Pharyngeal Swallow in Neonates
Deglutition Disorders · Respiratory Distress Syndrome In Premature Infants · Respiratory Aspiration
Primary: Pharyngeal Phase Dysphagia — 7; 7 Participants
N/A N=102 Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
High-Frequency Ventilation · Intermittent Positive-Pressure Ventilation · Newborn Morbidity
Primary: Partial Pressure CO2 (pCO2) : Data From the Crossover Phase of the Study — 38.7; 36.8 mm Hg
N/A N=360 NHFOV as Primary Support in Very Preterm Infants With RDS
to Test the Hypothesis That NHFOV is More Effective Than nCPAP in the Treatment of Respiratory Distress Syndrome (RDS) in Verypreterm Neonates
Primary: Treatment Failure Within 72 Hours After Randomization 72 Hours After Randomization Need for Invasive Mechanical Ventilation — 48; 27 Participants
Phase 3 N=124 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
RDS of Prematurity
Primary: Duration of NIV Support — 89; 87 HOURS — p=< 0.05
N/A N=30 In-home Evaluation of a Noninvasive Open Ventilation System in Patients With Severe Respiratory Insufficiency
Pulmonary Disease, Chronic Obstructive · Airflow Obstruction, Chronic · Chronic Obstructive Airway Disease
Primary: Activity Endurance Time — 7.24; 13.38 minutes — p=<0.05
N/A N=28 Study of Standard Noninvasive Positive Pressure Ventilation (NIPPV) and Low Expiratory Pressure NIPPV in ALS Patients
Amyotrophic Lateral Sclerosis
Primary: Hours of NIPPV Usage — 49.94; 45.75 hours
N/A N=100 Extending CPAP Therapy in Stable Preterm Infants to Increase Lung Growth and Function
Neonatal · Premature Birth · Respiratory Distress Syndrome
Primary: Alveolar Volume — 500.2; 418.1 mL — p=<0.05
N/A N=121 Somatosensory Modulation of Salivary Gene Expression and Oral Feeding in Preterm Infants
Infant, Extremely Low Birth Weight · Feeding Behavior
Primary: Salivary Gene Expression — 21.344; 21.420; 20.931; 21.100 Delta-CT — p=<0.01
N/A N=48 NICU Oxygen Control Study
Hyperoxia · Hypoxia
Primary: Elapsed Time to Respond to SpO2 Alarm — 51.408; 41.523 seconds — p=0.003
N/A N=410 Monitoring Neonatal Resuscitation Trial
Resuscitation · Neonatal Prematurity · Positive-Pressure Respiration
Primary: Percentage of Positive-Pressure Ventilation Inflations Between 4 - 8 Mls/kg — 30.2; 30.7 percentage of inflations — p=0.896
N/A N=16 BabyStrong Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Paired Bottle Feeding to Improve Oral Feeding
Infant Feeding Problems, taVNS
Primary: Bradycardia — 0; 0; 0; 0 Participants
N/A N=30 Intra-Abdominal Hypertension in Neonatal Intensive Care Patients
Intra-Abdominal Hypertension
Primary: Intra-abdominal Pressure(IAP) Measurements in NICU Patients. — 1219 IAP measurements
N/A N=23 Autotitrating Versus Standard Non-invasive Ventilation (NIV) in Newly Diagnosed Patients
Nocturnal Hypoventilation · Neuromuscular Disease · Chest Wall Disorder
Primary: Overnight Mean Oxygen Saturation — 96; 96 % SaO2 — p=0.13
N/A N=111 Cerebral Oxygenation and Autoregulation in Preterm Infants
Intraventricular Hemorrhage of Prematurity · Complications of Prematurity
Primary: Mortality Before Hospital Discharge — 11 Participants
N/A N=39 A Comparison of Different Ventilation Strategies in Infants Using the PLMA™
Ventilation
Primary: Mean Values of End-tidal Carbon Dioxide and Tidal Volume Compared Between the Spontaneous Ventilation and Pressure Support Ventilation Groups. — 4.5; 7; 51.8; 49 cc/kg
Phase 3 N=1,032 Newborn Ventilation in the Delivery Room: Could it be Improved With a T-piece Resuscitator?
Resuscitation
Primary: Proportion of Infants With a HR ≥ 100 Bpm at 2 Minutes of Life. — 93.7; 88; 93 percentage of participants
N/A N=68 Clinical Stabilization of Hypercapnia: NIPPV v HVNI
Hypercapnic Respiratory Failure · Chronic Obstructive Pulmonary Disease · Dyspnea
Primary: Rated Perceived Dyspnea [RPD] — 5.4; 5.6; 3.97; 4.54 units on a scale (0-10)