Phase 4 N=156 Preventing Propofol-associated Injection Pain
Pain
Primary: Verbal Pain Score — 3; 0; 0 Units on a scale — p=<0.0001
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=50 Comparison of Two Techniques of IV Lidocaine on Propofol Injection Pain
Injections, Intravenous
Primary: Patient Expression of Pain — 0.76; 0.04 units on a scale
Phase 4 N=116 Preventing Propofol Injection Pain: Prospective Randomized Trial Comparing Propofol Versus Fospropofol
Complication of Injection · Pain
Primary: Compare Incidence and Intensity of Pain on Injection That is Caused by Propofol (Lipid Emulsion) Versus the Test Drug Fospropofol.
Phase 3 N=100 Use of a Modified Propofol Emulsion in Adults
Anesthesia
Primary: Incidence of Expression of Pain During Injection — 1; 7 participants
Phase 4 N=200 Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
General Anesthesia · Intravenous Anesthesia
Primary: Percentage of Participants Reporting Pain With Injection of Propofol — 29; 57; 41; 46 percentage of patients reporting pain
Phase 4 N=76 Combining Placing a Synera Patch With Propofol/Lidocaine Mixture to Decrease Pain With IV Propofol Injection
Pain on IV Injection of Propofol.
Primary: Number of Children in Each Group Who Don't Feel Pain or Have Mild Pain on Propofol Injection. — 29; 19 participants
N/A N=100 Vibration Analgesia in Propofol Infusion During Anesthesia Induction
Pain, Acute
Primary: Level of Pain as Observed by Two Independent Observers Following Propofol Injection, With or Without a Vibration Analgesia Adjunct — 3.1; 1.4 units on a scale
N/A N=80 Pain After Laparoscopic Cholecystectomy
Postoperative Pain
Primary: Pain Measured on Verbal Scale of 0-10 — 2.7; 1.7; 3; 2.1 units on a scale
Phase 3 N=74 Low-dose Propofol for Pediatric Migraine
Migraine Headache
Primary: Change in Self-Assessed Pain — 51; 59 percentage change
Phase 4 N=109 Efficacy of IV Lidocaine at Alleviating Pain Associated With Propofol Infusion in Pediatric Patients Undergoing Sedation
Pain
Primary: Maximal Pain/Discomfort — 4.7; 4.3; 5.0 units on a scale
Phase 4 N=99 Propofol in Emergence Agitation
Emergence Agitation
Primary: Number of Participants With Emergent Agitation — 16; 24 Participants
Phase 4 N=150 Local Anesthetics for Pain Reduction Prior to IV Line Placement
Pain · Local Anesthesia for Peripheral Intravenous Catheterization
Primary: Pain Score Following Anesthetic Administration — 2.81; 1.64; 2.05 units on a scale
Phase 4 N=50 Dexmedetomidine vs Propofol TIVA (Total Intravenous Anesthesia) and Interscalene Block
Shoulder Pain
Primary: Number of Participants That Need an Airway Intervention. — 0; 5 participants
Phase 4 N=31 Pain Outcomes Following Intralesional Corticosteroid Injections
Keloid · Alopecia Areata · Acne
Primary: Pain Outcome: Visual Analog Scale — 5.4; 2.7 Score on a scale
Phase 4 N=23 Anesthesia and Postoperative Pain
Postoperative Pain
Primary: Score on a Pain Rating Scale (Numerical Analog Score) — 1.5; 4.9 scores on a scale
Phase 4 N=481 Comparison of Two Lidocaine Administration Techniques
Pain
Primary: Pain Assessment: Overall — 15.3; 19.0 units on a scale
Phase 1 N=82 Investigation of Pain During Subcutaneous Injections With Different Injection Speed and Volume Combinations
Diabetes · Diabetes Mellitus, Type 1 · Diabetes Mellitus, Type 2
Primary: Injection Pain (VAS mm) — 20.0; 12.8; NA; NA mm
Phase 4 N=34 Peri-operative Use of a Pain Injection in Pediatric Patients With Cerebral Palsy
Cerebral Palsy · Hip Dysplasia · Pain, Postoperative
Primary: Opioid Consumption — 0.41; 1.87 mEQ/kg
N/A N=73 Effect of Sedation on Diagnostic Injections
Sacroiliac Joint Pain · Sympathetically Maintained Pain
Primary: Pain Score — 2.2; 3.4 units on a scale
N/A N=60 Needle-Free Injection of Lidocaine for Local Anesthesia Prior to Trigger Digit Injection
Trigger Finger
Primary: Difference in Visual-analog Score (VAS) for Anticipated Pain Prior to Injection and Actual Pain After Injection — 1.6; 2.8 units on a scale
Phase 4 N=50 Evaluation of Pain With Lidocaine-Mixed Radiesse® Injectable Dermal Filler
Nasolabial Folds
Primary: Pain Score Using a 10-cm Visual Analog Pain Scale (1 = no Pain, 10 = Very Severe Pain) — 2.8; 6.6 cm
N/A N=102 Evaluation of Pain With Radiesse® With Lidocaine for Nasolabial Folds
Nasolabial Folds
Primary: Pain Score Using a 10-cm Visual Analog Scale (VAS) for Pain (0 = no Pain, 10 = Very Severe Pain) — 2.32; 6.73 units on a scale — p=<0.0001
Phase 4 N=80 Effects of Epidural Local Anesthetics on Propofol Induction
General Anesthesia · Propofol Target-controlled Infusion · Thoracic Epidural Anesthesia
Primary: Propofol Effect-site Concentration — 1.76; 1.14; 1.09; 1.04 ug/ml
N/A N=71 Effect of IV Lidocaine Infusions on Pain
Pain
Primary: Present Pain Intensity — 6.25; 5.64; 4.92; 4.18 Units on a scale
Phase 4 N=421 Pain Increases After Shoulder Injection
Shoulder Pain
Primary: Incidence of a Flare Reaction — 44; 8; 149; 191 Person-visits
Phase 3 N=34 Co-administration of Propofol and Remifentanil for Lumbar Puncture in Children
Spinal Puncture
Primary: Duration of Apnea — 110; 73 seconds
Phase 4 N=271 Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Procedural Sedation
Primary: Clinical Interventions During Sedation — 41; 33; 48 Clinical interventions performed
Phase 2 N=64 A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children
Hematologic Diseases · Neoplasms
Primary: Dose of Remifentanil Required to Prevent Movement in Response to Lumbar Puncture Needle Insertion — 0.96; 0.28; 1.50; 0.52 micrograms/kg
Phase 3 N=159 IVPCA in the Management of Pain Following Major Intracranial Surgery
Intracranial Surgery
Primary: Hourly Pain Scores — 2.5; 3.6; 3.7; 5.2 units on a scale
Phase 4 N=56 Ketamine and Propofol for Upper Endoscopy
Anesthesia
Primary: Dose of Propofol Required to Prevent Movement (Response) to Insertion of Endoscope Into the Patient's Esophagus — 6.1; 4.5; 4.7; 1.1 mg/kg