Phase 3 N=201 Risk of Oxygen During Cardiac Surgery Trial
Cardiac Surgery
Primary: Intraoperative Systemic Oxidative Damage — 69; 83 pg/ml
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Phase 3 N=100 Does High Intraoperative Inspired Oxygen Reduce Postoperative Arterial Oxygen Saturation?
Atelectasis
Primary: Oxygen Requirement to Maintain SpO2>90% — 1; 1; 1; 1 liters per minute
N/A N=60 Effect of Peri-operative Supplemental Oxygen in Wound Infection After Appendectomy
Perioperative Hyperoxygenation · Wound Infection
Primary: ASEPSIS Score — 30; 30; 0; 0 participants — p=0.5
N/A N=300 Supplemental Oxygen Reduces Surgical Infection
Wound Infection
Primary: Incisional Surgical Wound Infection — 22; 35 participants — p=0.04
N/A N=40 Pre-Oxygenation Techniques in Pregnancy
Preoxygenation
Primary: End Tidal Oxygen Concentration (ETO2) Following Tidal Volume Breathing Using Either Face Mask or OptiFlow — 91.0; 87.4 Percentage units of end-tidal oxygen
N/A N=150 Preoxygenation With Positive Inspiratory Pressure During Induction of Anesthesia
Anesthesia
Primary: Time for Preoxygenationfrom Face Mask Positioning to FEO2=90% — 190; 153; 140 seconds
N/A N=1,301 Pragmatic Trial Examining Oxygenation Prior to Intubation
Acute Respiratory Failure
Primary: Incidence of Hypoxemia — 57; 118 Participants
N/A N=22 Improved Patient Recovery After Anesthesia With Hypercapnia Hyperpnoea
Hypercapnia
Primary: Recovery From Anesthesia — 53.0; 62.9 minutes — p=>0.05
N/A N=56 High Flow vs Conventional Oxygen in Head and Neck Surgery
Pulmonary Disease
Primary: Proportion of Patients With Post-operative Pulmonary Complication — 2; 11 Participants
N/A N=5,749 Supplemental Oxygen in Colorectal Surgery: A Quality Improvement Project
30% Oxygen Concentration During Colorectal Surgery · 80% Oxygen Concentration During Colorectal Surgery
Primary: Number of Participants With One or More Composite Complications — 314; 314 Participants — p=0.85
N/A N=29 Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period
Hypoplastic Left Heart Syndrome · Total Anomalous Pulmonary Venous Return · Truncus Arteriosus
Primary: Systemic Oxidative Stress Based on Thiobarbituric Acid Reactive Substances (TBARS) — 1.21; 1.93; 1.09; 1.77 Fold Change from Baseline — p=<0.01
Phase 2 N=96 Normobaric Hyperoxia for Intracerebral Hemorrhage
Normobaric Hyperoxia · Intracerebral Hemorrhage
Primary: Percentage of Patients With mRS 0-3 — 39; 27 Participants
N/A N=50 EPO2-A: Evaluation of Pre-Oxygenation in Morbid Obesity: Effect of Position and Positive Pressure Ventilation
Obesity, Morbid
Primary: Non Hypoxic Apnea Time — 216.7; 258.2 seconds — p=0.005
N/A N=21 Oxygen Saturation Monitoring During Surgery
Sleep Apnea, Obstructive
Primary: Number of Participants With Saturation Pattern Detection (SPD) Indicative of Repetitive Reductions in Air Flow — 4; 0 Participants
N/A N=51 Impact of Prophylactic High Flow Nasal Oxygen in Post-Operative Thoracic Surgical Patients
Post-operative Pulmonary Complications
Primary: Number of Participants With Post-operative Pulmonary Complications — 1; 2 Participants — p=0.680
N/A N=212 Intrapartum Maternal Oxygen Supplementation: Effects on the Mother and Neonate
Intrauterine Resuscitation
Primary: Umbilical Artery Malondialdehyde — 9.8; 10.2 umol/L
N/A N=360 Apneic Oxygenation During Airway Management in Pediatric Patients
Hypoxia
Primary: Time to First Event: Pulse Oximetry at 95%, or Successful Intubation — 106; 169 seconds
N/A N=200 Cerebral Oximetry and Neurocognitive Functions in Cardiosurgical Patients
Coronary Artery Disease · Postoperative Cognitive Dysfunction · Neurological Impairment
Primary: Difference in Incidence of Cognitive Impairment Between Groups. Change Between Preoperative and Postoperative Cognitive Function Was Assessed by Performing Standardized…
N/A N=2,860 Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project
Orthopedic Surgery · Ventilation
Primary: Time-weighted Average SaO2/FiO2 Ratio in the Postanesthesia Care Unit (PACU) — 355; 350; 353; 352 ratio — p=0.042
N/A N=72 Positive Pressure at Induction of Anesthesia in Children
Continuous Positive Airway Pressure · Hypoxia · General Anesthesia
Primary: Time Between Onset of Apnea and the Drop in 95% Oxyhemoglobin Saturation Levels — 227.65; 133.68 seconds — p=<0.0001
Phase 1 N=16 Reoxygenation After Cardiac Arrest II (REOX II Study)
Cardiac Arrest
Primary: Plasma Isofurans (pg/mL)/Isoprostanes (pg/mL) Ratio
N/A N=100 Oxygen Saturation Patterns in Post-Op Patients at Risk for Obstructive Sleep Apnea
Obstructive Sleep Apnea
Primary: Presence of Repetitive Reductions in Nasal Airflow Patterns in the Pulse Oximetry Saturation Trend Data. — 30 participants
N/A N=500 The Performance of Two Oxygen Delivery Devices Used After General Anesthesia.
Hypoxemia
Primary: Number of Participants With Hypoxemia in Both Groups — 0; 0 number of participants
N/A N=20 EPO2-PV: Evaluation of Pre-Oxygenation Conditions in Morbidly Obese Volunteer: Effect of Position and Ventilation Mode
Morbid Obesity · Bariatric Surgery Candidate
Primary: Functional Residual Capacity — 2573; 2145; 2456; 2219 ml
N/A N=91 Preoxygenation Using THRIVE Versus Facemask in Parturients
Preoxygenation
Primary: Preoxygenation Duration — 3.6; NA; NA minutes
N/A N=482 The Use of Apneic Oxygenation During Prolonged Intubation in Pediatric Patients: a Randomized Clinical Trial
Intubation of Pediatric Dental Surgery Patients
Primary: Time of Oxygen Saturation Change — 30; 67; 75 seconds
N/A N=37 Preoxygenation With Nasal Cannula and Noninvasive Positive Pressure Ventilation
Hypoxia
Primary: End-tidal Oxygen — 78.1; 78.6 End tidal oxygen saturation percentage
N/A N=10 Correlating Brain Tissue Oxygen and Regional Cerebral Oximetry
Stroke
Primary: Correlation Between Regional Cerebral Oximetry (RSO2) and Cerebral Oxygen Tissue Tension (PbrO2). — .5 Spearman Correlation (rs) Coefficient — p=0.036
N/A N=34 Preoxygenation With Optiflow™ - the Effect of Speech on Lung Oxygenation.
Unrecognized Condition
Primary: End Tidal Oxygen Fraction — 43.9; 81.9 percentage of End-Tidal Oxygen Fraction
N/A N=63 High-Flow Nasal Cannula and Desaturation Episodes in the Morbidly Obese Patients
Desaturation of Blood · Obesity · Colonoscopy
Primary: The Number of Desaturation Episodes — 0; 0 Episodes