Phase 3 N=46 Cytokine Removal in Cardiopulmonary Bypass Patients
Elective Cardiac Surgical Interventions
Primary: IL-6 — 0; 0; 0; 0 pg/ml
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=138 Surgical Stress Markers for Postoperative Complications: a Prospective Study
Operative Procedures, Complications
Primary: Predictive Value of Postoperative Albumin Decrease in Terms of Surgical Stress and Postoperative Complications — 11.3 g/L
Phase 2 N=24 Oxidative Stress and Surgical Recovery
Surgical Recovery · Pain, Postoperative
Primary: Phosphorylation of STAT-3 in MDSC (Myeloid-derived Suppressor Cells) — 2.162; 2.025 STAT3 archsinh ratio — p=0.5490
Phase 4 N=61 Assessing the Role of "Statin" Therapy and Perioperative Inflammatory Response in Patients Undergoing Major Orthopedic Surgery
Perioperative Inflammatory Response
Primary: Median Concentration of Aspartate Aminotransferase (AST) — 24.5; 24.5; 21.0; 20.0 U/L
Phase 4 N=55 Effect IV Ibuprofen and Inflammatory Responses
Gallbladder Disease
Primary: Stress Response Inflammation Markers :Cortisol and C Reactive Protein (CRP) — 173.6; 289.5; 17; 17 pg/mL
Phase 1 N=70 Inflammatory Markers in Trauma Patient Outcomes
Polytrauma
Primary: Length of Hospital Stay — 7; 8 days — p==0.275
Phase 3 N=458 Renin-angiotensin-aldosterone System (RAAS), Inflammation, and Post-Operative Atrial Fibrillation (AF)
Atrial Fibrillation
Primary: Postoperative Atrial Fibrillation — 27.2; 27.8; 25.9 percentage of patients — p=0.95
N/A N=40 Effect of Prewarming on Microcirculatory Response
Coronary Artery Bypass Graft Triple Vessel
Primary: Recovery Slope — 2.8; 3.1 % / sec (recovery slope unit)
N/A N=20 Acupuncture for Reduction of Inflammation
Thyroid or Parathyroid Surgery
Primary: Reduced Pain Medication Requirement — 5.43; 7.36 mg of Morphine
N/A N=94 Impact of Expanded Peri Operative Warming
Hypothermia · Complications
Primary: Incidence of Hypothermic Events — 5; 10 participants — p=0.12
Phase 4 N=30 Steroids in Bilateral Total Knee Replacement
Postoperative Inflammatory Response
Primary: Decrease in IL6 Level — 359.4; 381.6 pg/ml
Phase 2 N=51 Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Tetralogy of Fallot (TOF) · Ventricular Septal Defects (VSD) · Atrioventricular Septal Defects (AVSD)
Primary: ACTH and Cytokine Levels — 116.9; 182.7; 135.3; 44.5 pg/mL
Phase 3 N=3,395 Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
Perioperative Optimization
Primary: 30 Day Hospital Free Days — 27; 27; 26; 27 Number of hospital free days
N/A N=12 Inflammation and Protein Restriction
Protein Restriction · Diet · Inflammation
Primary: Changes in the Human Intestinal Microbiome That Result From Short Term Dietary Adjustment. — 232; 172; 145; 93 Number of immunity related genes — p=0.05
N/A N=40 Effect of Steroids on Thrombosis (Blood Clot Formation) and Inflammation in Patients Undergoing Hip Surgery
Total Hip Replacement
Primary: Serum Prothrombin Fragment 1 and 2 (PF 1.2) — 334.15; 298.12; 778.33; 619.21 pmol/mL
Phase 4 N=86 The RAS, Fibrinolysis and Cardiopulmonary Bypass
Coronary Artery Disease · Angiotensin Converting Enzyme · Angiotensin Receptor Blockers
Primary: Tissue-type Plasminogen Activator (t-PA) Antigen Response — 14.36; 14.05; 11.97; 27.65 ng/mL — p=0.28
N/A N=5,056 Perioperative Hypothermia and Myocardial Injury After Non-cardiac Surgery
Perioperative Care · Surgery--Complications · Hypothermia; Anesthesia
Primary: Number of Participants With a Composite Outcome Consisted of Myocardial Injury After Non-cardiac Surgery (MINS), Non-fatal Cardiac Arrest, and All-cause Mortality — 239…
N/A N=97 Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Quality of Life · Postoperative Complications · Acute Pain
Primary: Quality of Recovery - 40 Items Questionnaire Score (QoR-40) — 162.7; 167.6 score on a scale of 200 — p=0.54
Phase 2 N=86 The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery
Postoperative Cognitive Dysfunction
Primary: Interleukin-6 Concentration in Peripheral Blood. — 27.2; 26.6; 104; 97.7 pg/ml
N/A N=105 Anesthesia and Lymphocytes Apoptosis
Anesthesia
Primary: Lymphocyte Count — 0.55; 0.73; 0.73 cells/nanoliter
N/A N=174 Evaluation of the Predictive Nature of the Postoperative CRP on Postoperative Recovery in Patients Undergoing Colorectal Resection (CRP-Track)
Colorectal Postoperative Complication
Primary: C-reactive Protein Rate — 47.9; 81.0; 50.0; 79.5 percentage
Phase 4 N=280 Anti-inflammatory Effects of Colchicine in PCI
Coronary Artery Disease
Primary: Percent Change in Post-procedural IL-6 Concentration From Baseline to 30 Min -1 hr After PCI — 0; 20 % change — p=0.31
N/A N=64 Remote Ischemic PreConditioning Effect on Postsurgical Pain
Pain
Primary: Comparison of Pain Intensity and Unpleasantness Postoperatively — 4.82; 4.83; 4.05; 4.81 units on a scale
Phase 2 N=16 Inhaled NO as an Anti-inflammatory and Anti-reperfusion Agent in Infants and Children Undergoing Cardiopulmonary Bypass
Congenital Heart Disease
Primary: Serum Inflammatory Mediators Post CPB — 3.8; 3.4; 90.9; 78.3 ng/mL — p=>0.05
Phase 3 N=60 High Dose Preoperative Cholecalciferol Supplementation and Perioperative Vitamin D Status
Hypovitaminosis D
Primary: Percent (%) Change in 25(OH)D 5 Days Following Supplementation With 100,000 IU Cholecalciferol — 8; -2 percent change in 25(OH)D
Phase 2 N=56 Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants
Complication Due to Immunization
Primary: The Change in the Number of CRE (Extracted From Printed Monitoring Tracings Compared to Noted Nurses' Surveillance) Following the First Dose of Pentavalent Vaccine in…
N/A N=47 Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
Post Operative Cognitive Dysfunction
Primary: Presence of Post Operative Cognitive Dysfunction (POCD) — 15 Participants
N/A N=64 Effects of Warmed, Humidified CO2 Insufflation on Body Core Temperature and Cytokine Response
Hypothermia
Primary: Intraoperative Change in Body Core Temperature — 35.73; 35.70; 35.78; 35.77 degrees °C
N/A N=141 Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Cardiac Arrest
Primary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001
N/A N=300 Supplemental Oxygen Reduces Surgical Infection
Wound Infection
Primary: Incisional Surgical Wound Infection — 22; 35 participants — p=0.04