N/A N=170 Stressor-evoked Brain and Cardiovascular Responses to Acute Psychological Stress
Acute Psychological Stress
Primary: Stressor-evoked Oxygen Consumption in mL/(kg·Min) (Stress - Baseline) — 0.265; 0.287 mL/(kg·min)
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=269 Does Social Buffering Continue to be Effective Over the Peripubertal Period When Friends Share the Stressor Experience?
Adolescent Behavior · Social Stress
Primary: Cortisol AUCi — 0.0043; 0.0256; 0.0177; 0.022 (ug/dl)*minutes
N/A N=202 Affective Social Buffering
Social Stress · Adolescent Behavior
Primary: Cortisol AUCi — -93.6397; -68.0959; -106.9105 (ug/dL)*minutes
N/A N=72 Biological Response to Brief Psychological Challenge
Acute Inflammatory Response to Psychological Stress
Primary: Cell-free Mitochondrial DNA — 165.79; 405.56; 175.45; 164.45 Copies per uL — p=0.86
N/A N=208 Neural Correlates of the Shift in Social Buffering of Social Evaluative Threat
Social Stress · Adolescent Behavior
Primary: Change in Cortisol AUCi — -0.04; 0.02; -0.01 (ug/dl)*minutes
N/A N=1,418 Effects of Arousal and Stress in Anxiety
Healthy Volunteers
Primary: Go Correct Hits Followed by Button Press — 90.9; 91.6 Percentage of correct responses
N/A N=120 College Student Stress: Transitions Over Time
Depressive Symptoms
Primary: Percentage of Eligible Participants Who Agreed to Participate in the Trial — 120 Participants
N/A N=606 Stress, Sex, and the Generalization of Fear
Psychological Stress
Primary: Fear-potentiated Startle Responses to the CS+ and CS- During Acquisition — 52.059; 19.162; 44.388; 9.732 Fear-potentiated startle (microvolts) — p=0.453
N/A N=6 Combined Effects of Prolonged Sitting and Mental Stress on the Cardiovascular System
Sedentary Behavior · Cardiovascular Risk Factor · Mental Stress
Primary: Mean Change in Brachial-femoral Pulse Wave Velocity (bfPWV) — -0.26; 0.22 m/s
N/A N=17 Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
Middle-aged Adults · Major Depressive Disorder
Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05
N/A N=94 Stress and the Sympathetic Nervous System in Adults With Depression
Major Depressive Disorder
Primary: Percent of Days Participants Report Stressors — 36; 40 percent of days
N/A N=199 Caregiver Self-Management of Stress
Caregiver Distress · Job Stress
Primary: 10-item Kessler Psychological Distress Scale (K10) — 23.38; 23.79 score on a scale — p=0.513
N/A N=97 Influence of Stress on Encoding and Prediction
Stress · Learning, Spatial
Primary: Changes in fMRI Signal — 0.261; -0.264 Pearson's rho — p=0.023
N/A N=53 Stress in Inflammatory Bowel Disease
Inflammatory Bowel Diseases · Psychological
Primary: Retention Rate — 23; 25; 19; 22 Participants
Phase 4 N=226 Stress Neuroadaptation in Tobacco Dependence
Nicotine Dependence
Primary: Overall Stressor Reactivity — 25.1; 22.5; 32.3; 16.9 microvolts
N/A N=50 Stress and CKD Among African Americans
Chronic Kidney Disease
Primary: Change in Subjective Units of Distress Scale (SUDS) Score — 2.92; 3.12 score on a scale
N/A N=323 Stress, Salt Excretion, and Nighttime Blood Pressure
Blood Pressure · Psychological Stress
Primary: Ratio of Awake-to-asleep Urinary Sodium Excretion Rate (Aim 1) — 1.4 Ratio of awake-to-asleep — p=0.0032
N/A N=119 Stress Response in Opioid Use Disorder
Opioid-use Disorder
Primary: Change in Negative Affect — 1.67; 1.25; 3.60 scores on a scale
Phase 2 N=121 Stress Management for Patients With Multiple Sclerosis
Multiple Sclerosis
Primary: No.of Gd+ Lesions From Week 8 to Week 24 — 46; 33; 5; 13 participants — p=0.04
N/A N=270 The Biology of Resilience
Oxytocin · Placebo
Primary: Systolic Blood Pressure Change From Baseline to Second Stress Task Experience - Autonomic Stress Response Measure — 9.4; 12.9; 11.3; 11.1 mm Hg — p=0.03
N/A N=308 Middle School Success Over Stress
Parenting · Parent-Child Relations · Depression
Primary: Change From Baseline in Parent Mental Health and Well-being (Parent Report) — .7442; .7523; .6484; .5571 score on a scale — p=.548
Phase 4 N=10 Brain and Stress Study
Stress, Psychological · Motivation
Primary: Change in Response Bias During the Probabilistic Reward Task — 0.195; 0.203 Ratio (Response Bias Score) — p=0.856
N/A N=23 Stress and the Nervous System
Autonomic Nervous System · Baroreflex · Stress, Physiological
Primary: Cardiovagal Baroreflex Sensitivity (Modified Oxford Technique) — 17.75; 16.90; 14.42; 17.27 ms/mmHg
Phase 2 N=65 Explorative Open Label Study of Efficacy Profile of Neurexan® in Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3089.4; 3253.4 mm*min — p=0.1233
N/A N=99 Adolescent Responses to Varying Environments in Virtual Reality Simulations
Residential Characteristics · Emotions · Stress, Psychological
Primary: Emotional Response — 3.65; 4.31; 1.29; 0.33 units on a scale
N/A N=48 Pain and Loneliness
Chronic Pain
Primary: Mean Change in Loneliness — -6.6; -2.5 score on a scale
N/A N=20 Social Support and Stress Reduction for Caregivers of Young Adults With IDD
Burden, Caregiver
Primary: Recruitment — 20 Participants
Phase 2 N=66 Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
Acute Stress Reaction
Primary: Acute Stress Measured by Tension — 3335.7; 3360.3 mm*min — p=0.7726
N/A N=50 Comparison of Two Behavioral Treatments for Stress Reduction
Stress
Primary: Brain Activity (fMRI) During the Body Scan Meditation — 74; 82 voxels
N/A N=87 Stress and Marijuana Cue-elicited Craving and Reactivity
Cannabis Use Disorders
Primary: Subjective Craving of Marijuana — 50.5; 52.3 Scores on a Scale