Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=42 The Effect of Microneedle Pretreatment on Topical Anesthesia
Pain
Primary: Visual Analog Scale Pain — 7; 12 Units on a Scale
Phase 3 N=44 Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
Anesthesia, Local · Photodamaged Skin · Topical and Infiltration Anesthetic Toxicity
Primary: Self-reported Pain After Laser Treatment — 4.5; 5.0 score on a scale — p=0.102
N/A N=49 Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Anesthesia
Primary: Participants Anesthetic Preference — 32; 16 participant preference selection
Phase 3 N=646 Topical Application of Cocaine HCl 4%, or 10%, or Placebo Solution in Local (Topical) Anesthesia
Any Ear Nose or Throat Conditions · With Identified Need for a Diagnostic Procedure or Surgery on or Through the Mucous Membranes of the Nasal Cavities
Primary: Immediate and Sustained Anesthetic Success for Cocaine HCl 4% Topical Solution and Placebo Topical Solution — 0.7093; 0.1969 proportion of participants — p=<0.0001
Phase 1 N=16 A Study of the Use of Microneedle Patches to Deliver Topical Lidocaine in the Oral Cavity
Topical Anaesthesia
Primary: VAS in Healthy Participants, When Topical 5% Lidocaine Dental Gel Was Applied to the Upper Palatal and Upper Anterior Buccal Sulcus Areas With a Microneedle Patch and a…
Phase 4 N=48 Comparison of Two Application Techniques for LET Gel
Lacerations · Pain, Procedural · LET
Primary: Visual Analog Scale Pain Score — 16; 16 mm
Phase 4 N=120 Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol
Esophagogastroduodenoscopy
Primary: Rate of Administration of Propofol 1% Required to Obtain Uniform Sedation During Endoscopy — 310.7; 280.1 mcg/kg/min — p=<0.05
N/A N=40 Comparison of Tetracaine 0.5% and Lidocaine 2% Jelly for Topical Phacoemulsification Cataract Surgery
Cataracts
Primary: Change in Ln(Bacterial Colony Count) From Pre-antibiotic Administration to Post Study Medication Swabs — -0.14; -0.52 Ln(bacterial colony count)
Phase 2 N=54 Topical Anesthetic Use In Pessary Management
Pain
Primary: VAS Score at the Time of Pessary Removal Adjusting for Baseline Pain — 1.76; 3.81 Centimeters — p=.02
Phase 2 N=40 Experimental Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 Anesthetic Spray in Normal Volunteers
Anesthesia
Primary: Duration of Anesthesia as Measured by Pin Prick Test (PPT) for One Spray CTY-5339-A Compared to One Spray CTY-5339-CB — 17.9; 16.4 minutes — p=0.322
N/A N=57 Anesthesia Preference for Intravitreal Injection: Topical or Subconjunctival
Age-related Macular Degeneration · Central Retinal Vein Occlusion · Diabetic Macular Edema
Primary: Number of Participants Who Preferred Subconjunctival Anesthetic at the Third Follow-up Visit — 50 participants
Phase 4 N=31 Anesthetic Effect Duration Assessment
Healthy Volunteers
Primary: Duration of Anesthesia(Minutes) — 80; 140; 0; 400 Minutes
Phase 3 N=338 Chloroprocaine 3% Gel Eye Drop as Topical Anestheticsin Phacoemulsification.
Cataract
Primary: Number of Participants in Each Treatment Group With a Successful Surface Anesthesia — 153; 152; 14; 19 participants
Phase 2 N=75 Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
No Disease State or Condition
Primary: Stage II: Duration of Anesthesia as Measured by Pin Prick Test (PPT) for One Spray CTY-5339-A Compared to One Spray CTY-5339-CB — 14.6; 7.4 minutes
Phase 4 N=13 The Pharmacokinetics of 4% Lidocaine Gel When Applied Topically to the Breasts
Adverse Effects
Primary: Pharmacokinetic Parameters Based on Plasma Concentration of Lidocaine and MEGX in Nanograms/Milliliter. — NA; NA nanograms/mililiter — p=<0.05
N/A N=76 Local Anesthesia and Pain Perception During an Amniocentesis
Pregnancy
Primary: Intensity of Perceived Maternal Pain as Measured by the Visual Analogue Scale (VAS) — 9.5; 18.4 units on a scale
N/A N=44 Lidocaine Administration Using STAR Particles
Anesthesia, Local
Primary: Percent of Sharp (as Opposed to Dull) Sensation Over Application Area — 51.6; 82.0; 55.7; 89.0 Percentage of area with sharp sensation
N/A N=11 Lidocaine Analgesia For Removal Of Wound Vac Dressings
Pain
Primary: Visual Analog Scale Pain Score — 6.5; 8.9; -2.4; 4.4 Visial Analog Pain Score (VAS)
Phase 4 N=103 Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
Eyelid Tumor · Eyelid Bump · Eyelid Deformity
Primary: Pain on Injection — 2.8; 3.6 score on a scale
Phase 4 N=14 Botulinum Toxin Type A Injection After Topical Anesthesia Versus Petrolatum Ointment
Forehead Rhytides · Forehead Wrinkles
Primary: Eyebrow Excursion — 10.57; 10.57 millimeters
N/A N=50 Postoperative Subtenons Anesthesia for Postoperative Pain in Pediatric Strabismus Surgery
Strabismus
Primary: Average Pain Score Over the First 30 Post-operative Minutes Using the CHEOPS Scale — 6.36; 6.57; 6.58 units on a scale
Phase 4 N=34 Lidocaine For Treatment of Post-operative Pain From Donor Sites Following Burn Injury.
Pain
Primary: Pain Change — -3.8; -4.0 units on a scale — p=<0.05
Phase 3 N=86 Topical Radial Artery Vasodilation
Cardiac Catheterization · Spasm
Primary: Change in Radial Artery Diameter — -5.6; 16.5 Percent change
N/A N=109 Anesthetic Effect of Lidocaine/Epinephrine Solution Delivered Via Iontophoresis to External Auditory Apparatus
Acute Otitis Media · Chronic Otitis Media · Recurrent Acute Otitis Media
Primary: Proportion of Subjects Who Achieved Anesthesia Effectiveness Per Investigator Assessment — 89.9 percentage of subjects
N/A N=100 Effect of Intra-cuff Lidocaine and Tetracaine on Tracheal Tube-induced Emergence Phenomena
Pharyngitis
Primary: Visual Analogue Scale(0-100mm) by the Subject. — 51; 40; 22; 9 mm
Phase 4 N=25 Effectiveness Study of Different Local Anesthetic Mixtures
Pain
Primary: Length of Action — 6.63; 7.02; 7.48; 7.16 minutes — p=0.359
Phase 2 N=110 Topical Amethocaine Gel for Intramuscular Injection in Term Neonates
Pain
Primary: Pain Scores Assessed by Neonatal Facial Action — 14; 18; 30; 44 Percentage of time — p=< 0.05
Phase 4 N=114 Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture
Pain · Anxiety
Primary: Pain From Venipuncture — 2.2; 2.1 scores on a scale — p=0.71
Early Phase 1 N=60 The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia
Anesthesia
Primary: Insertion Depth at Initial Sensory Detection — 7.75; 4.65; 0.4; 8.55 mm