Phase 2 N=101 AVERT Shock: Arginine Vasopressin During the Early Resuscitation of Traumatic Shock
Traumatic Shock
Primary: Number of Blood Products Transfused — 1.7; 3.0 Litre
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=5 Biological Response of Trauma Patients to Standard Trauma Resuscitation Therapy
Hemorrhagic Shock
Primary: Biological Response as Characterized by Selected Cytokines, Specifically Tumor Necrosis Factor Alpha (TNFα), Interleukin One (IL-1β), and Interleukin Six (IL-6).
N/A N=1,051 Shock, Whole Blood, and Assessment of TBI S.W.A.T. (LITES TO 2)
Hemorrhagic Shock · Traumatic Brain Injury
Primary: 4 Hour Mortality — 50; 32 Participants
N/A N=50 Effect of Remote Ischemic Conditioning on Trauma Patients With Hemorrhagic Shock
Hemorrhagic Shock
Primary: Neutrophil Oxidative Burst Activity — 302; 302; 298; 268 Median Fluorescence Intensity — p=0.56
Phase 2 N=191 Field Trial of Hypotensive Versus Standard Resuscitation for Hemorrhagic Shock After Trauma
Blunt Trauma · Penetrating Wound · Hemorrhagic Shock
Primary: Total Volume of All Crystalloid Given for Early Resuscitation (Feasibility) — 2.04; 1.04; 1 liters
Phase 2 N=50 Resuscitative Endocrinology: Single-dose Clinical Uses for Estrogen-Traumatic Hemorrhagic Shock (RESCUE - Shock)
Hemorrhagic Shock
Primary: Survival — 16; 21 participants — p=.252
Phase 2 N=50 Resuscitative Endocrinology:Single-dose Clinical Uses for Estrogen-Traumatic Brain Injury
Traumatic Brain Injury
Primary: Percent Passing the Galveston Orientation Amnesia Test (GOAT) Within 28 Days Post Injury — 12; 14 Participants — p=0.99
N/A N=95 Heart Rate Variability in Trauma Patients
Trauma
Primary: Base Deficit </= -6 — 12 participants
Phase 2 N=31 Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: A Pilot and Feasibility Study
Brain Injuries · Wounds and Injuries · Hemorrhage
Primary: Pediatric Quality of Life Inventory (PedsQL) — 64.9; 60.2; 67.2 Quality of life units * months
N/A N=121 Trauma Survivors Outcomes and Support Study IV
Posttraumatic Stress Disorder · Depression · Suicide
Primary: Change in Post Traumatic Stress Disorder (PTSD) Symptoms Over the Course of the Six Months After Injury — 47.0; 47.0; 43.9; 43.6 units on a scale — p=0.05
N/A N=51 NT-proBNP in ICU Postoperative/Posttraumatic Patients With Shock
SIRS · Sepsis · Shock
Primary: Pattern of NT-proBNP, Biomarkers and Surface Markers on Leukocytes — 902; 4,429 pg/ml
N/A N=20 Cardiogenic Shock Intravascular Cooling Trial
Cardiogenic Shock
Primary: Number of Participants With Episodes of Arrhythmia — 0; 1 Participants — p=1
Phase 2 N=150 Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury
Hemorrhage · Shock · Wounds and Injuries
Primary: Change in HLA-DR Expression on Monocytes 72 Hours After Drug or Placebo Administration in Patient Groups (0g TXA (Placebo); 2g TXA; 4g TXA)." — 0.503; 0.509; 0.532 fold…
Phase 4 N=26 Beta Blockade in in Traumatic Brain Injury
Brain Injuries, Traumatic
Primary: Mortality — 7.7; 33.3 percentage of participants
Phase 3 N=199 Low-Titer O Positive Whole Blood Versus Component Therapy for Emergent Transfusion in Trauma Patients
Hemorrhagic Shock · Acute Blood Loss Anemia · Traumatic Brain Injury
Primary: Packed Red Blood Cells Equivalents Units Transfused (1 Whole Blood Unit Treated as 1 Packed Red Blood Cell Unit and 1 Fresh Frozen Plasma Unit) — 3.8; 5.7 units
Phase 2 N=1,063 Prehospital Tranexamic Acid Use for Traumatic Brain Injury
Traumatic Brain Injury
Primary: Dichotomized Glasgow Outcome Scale Extended (GOS-E) at 6 Months — 107; 108; 110; 218 Participants — p=.1809
Phase 2 N=122 Brain Tissue Oxygen Monitoring in Traumatic Brain Injury (TBI)
Severe Traumatic Brain Injury
Primary: Fraction of Time That Brain Oxygen Levels Are Below the Critical Threshold of 20 mm Hg . — 0.15; 0.44 Proportion
N/A N=165 Hypoxemia in the First 24 Hours After Trauma - an Observational Study
Trauma · Trauma Injury · Hypoxemia
Primary: Occurrence of Hypoxemia — 5.1; 5.1 IR of episodes pr. 100 participant-hours — p=0.95
Phase 4 N=100 ORthopaedic Trauma Anemia With Conservative Versus Liberal Transfusion
Anemia
Primary: Postoperative Wound Infection (Superficial or Deep) or Other Perioperative Infection — 12; 3 Participants — p=.0122
N/A N=119 Optimal Fluid Resuscitation for Trauma Patients
Trauma
Primary: Mortality — 0 participants
Phase 2 N=200 Cold Stored Platelet in Hemorrhagic Shock
Trauma · Hemorrhage
Primary: Study Feasibility — 91; 82 Participants
N/A N=150 IV Iron for the Anemia of Traumatic Critical Illness
Trauma · ICU Anemia
Primary: RBC Transfusion — 47; 55 participants
N/A N=20 Endovascular Repair for the Descending Thoracic Aorta
Aorta Thoracic; Traumatic Rupture
Primary: Number of Participants With Major Adverse Events — 0 number of serious adverse events
N/A N=88 An Integrated-Delivery-of-Care Approach to Improve Patient Outcomes, Safety, Well-Being After Orthopaedic Trauma
Musculoskeletal Injury Trauma
Primary: Change From Baseline, at Weeks 2, 6 and 12 on the Patient Reported Outcome Measurement Information System (PROMIS) - Physical Function Between the Groups. — 18.65; 17.6…
N/A N=141 Anti-inflammatory Effect of Therapeutic Hypothermia in Out-hospital Cardiac Arrest Patients With Cardiogenic Shock
Cardiac Arrest
Primary: Survival Rate - Number of Participants Alive — 55; 20; 32; 34 Participants — p=<0.001
N/A N=30 Evaluation of Etomidate on Adrenal Function in Trauma Patients
Adrenal Insufficiency
Primary: Cortisol Levels Pre and Post Rapid Sequence Induction and Cortisol Stimulation Test
Phase 3 N=523 PreHospital Air Medical Plasma Trial
Hemmorhagic Shock During Air Medical Transport
Primary: Our Primary Outcome for the Proposal Will be 30 Day Mortality — 53; 89 Participants
N/A N=635 A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and Comorbidity
Posttraumatic Stress Disorder · Depression · Alcohol-Related Disorders
Primary: Change From Baseline PTSD Checklist- Civilian (PCL-C) Over the Course of the Year After Injury — -1.65; 0.08; -4.02; -1.44 score on a scale
N/A N=6 Deep Brain Stimulation for the Treatment of Traumatic Brain Injury
TBI (Traumatic Brain Injury)
Primary: Percent Change in Trail Making Test Part B Time to Completion — -25.6 percent change in time
Phase 2 N=50 Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest
Cardiac Arrest
Primary: Time to Shock Reversal — 55; 49 hours