N/A N=14 Vascular Dysfunction During Physical Inactivity
Aging · Vascular Endothelium · Skeletal Muscle
Primary: Brachial Artery Vascular Function — 5.1; 3.1; 4.4 percent vasodilation
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=30 Role of Flavanols In Cardiovascular Function in Healthy Aging
Aging
Primary: Cutaneous Blood Flow Response to Local Heating of the Skin. — 68; 70 percent change in mean skin blood flow
Phase 2 N=45 Targeting Inflammation to Treat Cardiovascular Aging
Vascular Stiffness · Endothelial Dysfunction · Diastolic Dysfunction
Primary: Carotid-femoral Pulse Wave Velocity (CFPWV) — 831.3; 785.1; 538.0; 839.6 cm/sec
N/A N=51 Passive Mobilization and Vascular Function
Endothelial Dysfunction · Aging · Bed Rest
Primary: Change of Delta Peak Blood Flow During sPLM — 91.9; -24.7 ml/min — p=0.0492
N/A N=68 Blood Flow, Muscle Regeneration and Sarcopenia
Sarcopenia
Primary: Muscle Satellite Cells — 3.2; 3.2; 4.0; 3.8 Number of Pax7+ cells/muscle fiber
N/A N=20 Sex Differences in Vascular Responses to Exercise
Aging
Primary: Change in FMD in Response to Chronic HIIT — 0.11; 0.57; 0.81; 0.10 % flow mediated dilation
N/A N=90 Exercise Training and Glucose Metabolism in Aging
Type 2 Diabetes Mellitus · Impaired Glucose Tolerance (Prediabetes)
Primary: Baseline Glucose Utilization — 0.0062; 0.0035 µmol/kgFFM/pmol insulin/min
N/A N=75 VItamin D Metabolism in SEnescent Cardiac Surgery Patients
Coronary Artery Bypass Grafting · Heart Valve Surgery
Primary: Peri- and Postoperative Time Course of Circulating 1,25-dihydroxyvitamin D in the First Postoperative Month in Cardiac Surgery Patients — 13; 4.2 percentage
N/A N=14 Muscle Capillarization and Sarcopenia
Sarcopenia
Primary: Skeletal Muscle Capillarization — 0.4; 0.2 capillaries per muscle fiber — p=0.27
N/A N=125 Non-invasive Computer-Aided Phenotyping of Vasculopathy
Carotid Atherosclerosis · Peripheral Arterial Disease
Primary: Measurement Bias of Calcification Analyzed by vascuCAP™ Non-invasively Relative to Histopathology as Ground Truth. — -0.47; .07 mm2
Phase 2 N=31 Red Blood Cell ATP Release and Vascular Function in Humans
Cardiovascular Diseases
Primary: Forearm Blood Flow Responses to Hypoxia After Administration of Intervention — 6.3; 6.2; 2.1; 8.4 mL/min — p=0.97
N/A N=23 Dietary Nitrate and Physiological Aging
Aging
Primary: Change in Carotid Chemosensitivity Following 4 Weeks of Dietary Nitrate Supplementation and Placebo in Older Adults — -0.13; -0.05; -0.10; -0.11 L/min/%SpO2
Early Phase 1 N=16 Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
Aging · Arterial Stiffness · Endothelial Dysfunction
Primary: Change in Carotid Artery Compliance in mm/mmHg x 10-1 — 0.88; 0.87; 0.90; 0.79 mm/mmHg x 10-1
N/A N=23 Long Sleep Duration and Vascular Function
Sleep
Primary: Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed — -1.5; 0.5 mm Hg — p=0.36
Phase 3 N=24 Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
Diabetes Mellitus, Type 2
Primary: Glygocalyx Integrity - Perfused Boundary Region — 0.11; -0.16 Delta micrometers (mcm)
N/A N=100 The Effects of Swimming on Elderly Women With Stage-2 Hypertension
Menopause · Hypertension
Primary: Arterial Stiffness — 7.8; 10.0 m/s
N/A N=202 Dietary Intervention and Vascular Function
Cardiovascular Disease
Primary: Percent Change in Flow Mediated Dilatation (FMD) — -0.39; -0.07; -0.08 post-occlusion diameter change as % — p=0.238
Phase 2 N=32 Healthy Aging Through Functional Food
Glucose Intolerance · Aortic Stiffness · Vasodilation
Primary: Area Under the Curve for Oral Glucose Tolerance Test (oGGT) — 10.8; 11.0; 9.9; 10.6 mM h
N/A N=20 Vascular Endothelium Changes After Bariatric Surgery (Endothelial Progenitor Cells)
Type 2 Diabetes
Primary: Change in Late Outgrowth Endothelial Progenitor Colonies — 0.3; 0.2; 3.1; 0.1 LOEPC colonies — p=<0.05
N/A N=17 Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
Middle-aged Adults · Major Depressive Disorder
Primary: Nitric Oxide (NO)-Mediated Endothelium-dependent Dilation (EDD) — 70; 74 percentage — p=>0.05
N/A N=89 Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
HIV Infection
Primary: Endothelial Function (Brachial Artery Reactivity) — 3.98; 3.37 percent dilation — p=0.10
N/A N=130 Effect of Vitamin D3 on Vascular Function
Vitamin D Deficiency
Primary: Pulse Wave Velocity for Vascular Stiffness — 29.3; 27.6 m/s
N/A N=18 The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women
Endothelial Dysfunction
Primary: Percent Change in Brachial Artery Flow-mediated Dilation at Each Time Point — 4.11; 6.93; 5.86; 3.20 Percent Change
Phase 4 N=34 Retinol on Human Skin Aging in East Asian Descent
Intrinsic Aging of Skin
Primary: Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo) — 23; 21 genes
N/A N=17 Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women
Cognitive Impairment · Executive Dysfunction · Endothelial Dysfunction
Primary: Changes in Prefrontal Cortex Brain Activation at 6 Months — 90.64; -62.20; 28.07; -79.04 beta-weight
Phase 2 N=43 Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease
Cardiovascular Disease · Chronic Kidney Disease
Primary: Aortic Pulse Wave Velocity (PWV) — 9.90; 9.96; 7.62; 8.57 m/s — p=0.685
Early Phase 1 N=26 Sex Differences in the Dilatory Response of Compound 21
Sex Differences
Primary: Microvascular AT2R Sensitivity Following Local Control Treatment — 15; 25 percentage of maximal blood flow
Phase 1 N=62 Muscle Perfusion and Protein Metabolism in Elderly
Aging
Primary: Mixed Muscle Fractional Synthesis Rate (FSR) — 0.061; 0.070; 0.066; 0.070 Fractional Synthesis Rate (pecent/hour)
N/A N=338 Vascular Risk After Kidney Transplantation
Cardiovascular Disease · Chronic Kidney Disease · Diabetes
Primary: Carotid Intima Media Thickness (CIMT) — 0.044 millimeters (mm)
Phase 4 N=24 How Vitamin D Analogues Affect Endothelial Cells in Patients on Dialysis
Hyperparathyroidism, Secondary · Kidney Failure, Chronic
Primary: Change in Endothelial Cell Function — .23 percent change in FMD