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Home › Medications › 5-fluorouracil

5-fluorouracil

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of 5-fluorouracil

77 trials tracked of 5-fluorouracil: 26 in phase 3 or 4 and 15 with published results. The most-cited published study has 689 citations.

77Trials tracked
26Phase 3 & 4
0Recruiting
15With published results
Phase distribution
Phase 4 2 Phase 3 24 Phase 2 47 Phase 1 3 Other / NA 1
  1. Phase 3 Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-859/KEYNOTE-859) Completed · 689 cited
  2. Phase 3 Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer Completed · 567 cited
  3. Phase 3 A Study of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Metastatic Gastroesophageal Junction or Gastric Cancer Completed · 490 cited
  4. Phase 3 Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585) Completed · 388 cited
  5. Phase 3 A Study to Compare Subcutaneous (SC) Versus Intravenous (IV) Administration of Herceptin (Trastuzumab) in Women With Human Epidermal Growth Factor Receptor (HER) 2-Positive Early Breast Cancer Completed · 352 cited
  6. Phase 3 Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100) Completed · 230 cited
Show 44 more trials
  1. Phase 3 Docetaxel, Doxorubicin (A), Cyclophosphamide (C) (TAC) vs 5-Fluorouracil, A, C (5FAC) Breast Cancer Adjuvant Treatment Completed · 209 cited
  2. Phase 3 A Study of Trastuzumab Emtansine (Kadcyla) Plus Pertuzumab (Perjeta) Following Anthracyclines in Comparison With Trastuzumab (Herceptin) Plus Pertuzumab and a Taxane Following Anthracyclines as Adjuvant Therapy in Participants With Operable HER2-Positive Primary Breast Cancer Completed · 65 cited
  3. Phase 3 Phase III Trial to Assess Efficacy and Safety of Cetuximab for the Treatment of Chinese Participants With Head and Neck Cancer Completed · 57 cited
  4. Phase 3 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Completed · 51 cited
  5. Phase 3 A Study of Pertuzumab in Addition to Chemotherapy and Trastuzumab as Adjuvant Therapy in Participants With Human Epidermal Growth Receptor 2 (HER2)-Positive Primary Breast Cancer Completed · 39 cited
  6. Phase 3 Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer Completed · 34 cited
  7. Phase 4 CSP #562 - The VA Keratinocyte Carcinoma Chemoprevention Trial Completed · 22 cited
  8. Phase 3 Pembrolizumab Plus Epacadostat, Pembrolizumab Monotherapy, and the EXTREME Regimen in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-669/ECHO-304) Completed · 21 cited
  9. Phase 3 Tislelizumab in Combination With Chemotherapy as First-Line Treatment in Adults With Inoperable, Locally Advanced or Metastatic Gastric, or Gastroesophageal Junction Carcinoma Completed · 9 cited
  10. Phase 4 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed
  11. Phase 3 A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer Completed
  12. Phase 3 Andecaliximab With mFOLFOX6 as First Line Treatment for Advanced Gastric or Gastroesophageal Junction Adenocarcinoma Completed
  13. Phase 3 Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Participants With Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma (MK-3475-585/KEYNOTE-585)-China Extension Completed
  14. Phase 3 Study Of FOLFIRI Chemotherapy With Or Without Sunitinib In Patients With Metastatic Colorectal Cancer Completed
  15. Phase 3 A Study in Second Line Metastatic Colorectal Cancer Completed
  16. Phase 3 Docetaxel in Node Positive Adjuvant Breast Cancer Completed
  17. Phase 3 Prospective Randomized Trial Comparing Gastrectomy, Metastasectomy Plus Systemic Therapy Versus Systemic Therapy Alone: GYMSSA Trial Completed
  18. Phase 3 Study of MM-398 With or Without 5-FU/LV, Versus 5-FU/LV in Patients With Metastatic Pancreatic Cancer Completed
  19. Phase 3 A Trial to Determine the Safety and Anti-tumor Activity Profile of the Combination of Cetuximab and Concomitant Cisplatin Plus 5-Fluorouracil (5-FU) in Subjects With Recurrent and/or Metastatic Squamous Cell Carcinoma in Head and Neck Completed
  20. Phase 3 A Study of Bevacizumab in Combination With Capecitabine and Cisplatin as First-line Therapy in Patients With Advanced Gastric Cancer Completed
  21. Phase 2 A Study to Assess the Pharmacokinetics of Ramucirumab (IMC-1121B) in Combination With FOLFIRI Completed
  22. Phase 2 De-Escalation Therapy for Human Papillomavirus Negative Disease Completed
  23. Phase 2 A Trial of Single Agent Axitinib as Maintenance Therapy for Patients With First Line Metastatic Colorectal Cancer (mCRC) Completed
  24. Phase 2 A Study of Epacadostat in Combination With Pembrolizumab and Chemotherapy in Participants With Advanced or Metastatic Solid Tumors (ECHO-207/KEYNOTE-723) Completed
  25. Phase 2 5-fluorouracil Versus Placebo in Periocular Full Thickness Skin Grafts Completed
  26. Phase 2 Phase Ib/II Trial of Nal-Irinotecan and Nivolumab as Second-Line Treatment in Patients With Advanced Biliary Tract Cancer Completed
  27. Phase 2 Radiation Therapy and Chemotherapy in Treating Patients With Stage I Bladder Cancer Completed
  28. Phase 2 FOLFOXIRI Plus Panitumumab Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only Completed
  29. Phase 2 Phase 2 Trial of Pertuzumab and Trastuzumab With Weekly Paclitaxel and Chemotherapy for HER2 Positive Breast Cancer Completed
  30. Phase 2 A Pilot Study of Pre- and Post-surgery Chemotherapy With mFOLFIRINOX in Localized, Resectable Pancreatic Adenocarcinoma Completed
  31. Phase 2 Second Line ColoRectal Cancer Therapy in Combination With Combination of FOL- Folinic Acid(Leucovorin), F - Fluorouracil and OX - Oxaliplatin (FOLFOX) Completed
  32. Phase 2 Bevacizumab With Pelvic Radiotherapy And Primary Chemotherapy in Patients With Poor-Risk Rectal Cancer Completed
  33. Phase 2 Study of Gamma Interfereon in Metastatic Colorectal Carcinoma Completed
  34. Phase 2 Preoperative Chemo and Chemoradiotherapy for Adenocarcinoma of the Stomach and Gastroesophageal Junction (GEJ) Completed
  35. Phase 2 SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial Completed
  36. Phase 2 A Study of Ipatasertib (GDC-0068) in Combination With Fluoropyrimidine Plus Oxaliplatin in Participants With Advanced or Metastatic Gastric or Gastroesophageal Junction Cancer Completed
  37. Phase 2 Panitumumab, Nab-paclitaxel and Carboplatin for HER2 Negative Inflammatory Breast Cancer Completed
  38. Phase 2 Docetaxel, 5-Fluorouracil and Oxaliplatin in Adenocarcinoma of the Stomach or Gastroesophageal Junction Patients Completed
  39. Phase 2 Genotype-Directed Study Of Irinotecan Dosing In FOLFIRI + BevacizumabTreated Metastatic Colorectal Cancer Completed
  40. Phase 2 Oxaliplatin-Based Chemotherapy and Chemoradiotherapy or Chemoradiotherapy in Esophageal or Gastroesophageal Carcinoma Completed
  41. Phase 2 Pre-op Rectal ChemoRad +/- Cetuximab Completed
  42. Phase 2 Pharmacogenomically Selected Treatment for Gastric and Gastroesophageal Junction (GEJ) Tumors Completed
  43. Phase 2 Trial of mFOLFOX6 + Trastuzumab + Avelumab in Gastric and Esophageal Adenocarcinomas Completed
  44. Phase 2 Bevacizumab and Cetuximab in Combination With FOLFOX6 in Patients With Metastatic Colorectal Cancer Completed

Showing the 50 most-cited and recently-updated of 77 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Intralesional corticosteroid combination therapy shows odds ratio of 2.71 for improved keloid outcomes
Allergy & Immunology Meta-analysis
Intralesional corticosteroid combination therapy shows odds ratio of 2.71 for improved keloid outcomes Combining treatments may improve results for patients with keloids
This meta-analysis of keloid treatments found that combination therapy with intralesional corticosteroids and other agents yielded an odds r…
Combining corticosteroids with other treatments like 5-fluorouracil may offer better results and safety for people living with keloids.
Frontiers Oct 27, 2026
Pharmacokinetically guided 5-fluorouracil dosing reduces severe toxicity and improves response rates in colorectal cancer
Oncology Meta-analysis
Pharmacokinetically guided 5-fluorouracil dosing reduces severe toxicity and improves response rates in colorectal cancer Tailored dosing of 5-fluorouracil improves safety for colorectal cancer
This systematic review and meta-analysis of 809 patients found that pharmacokinetically guided 5-fluorouracil dosing significantly reduced s…
Tailoring 5-fluorouracil doses based on how a patient's body processes the drug can lower severe side effects and improve treatment response…
Sep 4, 2026
Evaluating High-Dose Vitamin D3 Supplementation in Metastatic Colorectal Cancer Treatment Regimens
Gastroenterology RCT
Evaluating High-Dose Vitamin D3 Supplementation in Metastatic Colorectal Cancer Treatment Regimens Testing High Dose Vitamin D3 for Patients with Metastatic Colorectal Cancer
A Phase 3 trial assessed if high-dose vitamin D3 improves outcomes in mCRC patients receiving bevacizumab-based chemotherapy.
Doctors tested if adding high doses of vitamin D3 to standard chemotherapy helped patients with advanced colon cancer live longer.
JAMA Sep 2, 2026
Traditional Chinese Medicine may reprogram tumor-associated macrophages to overcome chemotherapy resistance in gastric cancer
Infectious Disease Sys. Review
Traditional Chinese Medicine may reprogram tumor-associated macrophages to overcome chemotherapy resistance in gastric cancer Traditional Chinese Medicine may help fight gastric cancer cells
This narrative review explores how Traditional Chinese Medicine (TCM) components, including specific herbal formulae and active monomers, mo…
New research explores how traditional herbal formulas might reprogram immune cells to better fight gastric cancer and improve chemotherapy r…
Frontiers Aug 21, 2026
5-Fluorouracil and MAL-PDT vs Surgery for Bowen's Disease: 4-Year Outcomes
Dermatology RCT
5-Fluorouracil and MAL-PDT vs Surgery for Bowen's Disease: 4-Year Outcomes Surgery kept skin cancer away better than two light-based treatments in this trial
This multicenter RCT compared 5-fluorouracil, methylaminolevulinate photodynamic therapy (MAL-PDT), and surgical excision (SE) in 250 patien…
Surgery offered the highest chance of staying cancer-free for four years, while light-based treatments showed lower success rates in this st…
May 1, 2026