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Home › Medications › Ascorbic Acid

Ascorbic Acid

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of Ascorbic Acid

21 trials tracked of Ascorbic Acid: 8 in phase 3 or 4 and 4 with published results. The most-cited published study has 274 citations.

21Trials tracked
8Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 3 Phase 3 5 Phase 2 10 Other / NA 3
  1. Phase 3 Vitamin C, Thiamine, and Steroids in Sepsis Completed · 274 cited
  2. Phase 3 Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP) Completed · 93 cited
  3. Phase 3 Vitamin C and Septic Shock Completed · 61 cited
  4. Phase 4 Phosphate Lowering in CKD Trial Completed · 2 cited
  5. Phase 4 Study of High Dose Vitamin C On Outcome in Cardiac Surgery Patients Completed
  6. Phase 4 A Comparison of Solid and Soluble Forms of Cold and Influenza Remedies Completed
Show 15 more trials
  1. Phase 3 Vitamin C for Prophylaxis of Post-operative Atrial Fibrillation in On-pump Cardiac Surgery Procedures Completed
  2. Phase 3 Prophylaxis to Reduce Postoperative Atrial Fibrillation in Cardiac Surgery Completed
  3. Phase 2 Ascorbic Acid (Vitamin C) Infusion in Human Sepsis Completed
  4. Phase 2 Pharmacological Ascorbate for Lung Cancer Completed
  5. Phase 2 Arsenic Trioxide With Ascorbic Acid and Melphalan for Myeloma Patients Completed
  6. Phase 2 Vitamin C Infusion for TReatment in Sepsis and Alcoholic Hepatitis Completed
  7. Phase 2 A Phase Ib Study Evaluating the Safety and Tolerability of Vitamin C in Patients With Intermediate or High Risk Myelodysplastic Syndrome With TET2 Mutations Completed
  8. Phase 2 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Sepsis. Completed
  9. Phase 2 Vitamin C in Atrial Fibrillation Ablation Completed
  10. Phase 2 Vitamin C Infusion for Treatment in Sepsis Induced Acute Lung Injury Completed
  11. Phase 2 High Dose Vitamin C Intravenous Infusion in Patients With Resectable or Metastatic Solid Tumor Malignancies Completed
  12. Phase 2 Vitamin C & Thiamine to Treat Sepsis and Septic Shock Completed
  13. N/A Quantitative in Vivo Biomarkers of Oxidative Stress in Diabetes Completed
  14. N/A Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Completed
  15. N/A Influence of Endothelial Function on Central and Peripheral Causes Of Exercise Impairment in Type 2 Diabetes Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence
Nutrition & Obesity Medicine Meta-analysis
Vitamin D improves strength and reduces injuries in dancers, while iron lowers anemia prevalence Dancers take many supplements, but benefits are often unproven and risks remain unclear
This systematic review of dietary supplement and medication use in 654 female and 86 male professional and pre-professional dancers found vi…
Dancers use many supplements and painkillers, yet benefits are limited and potential health risks need more study before we can trust them.
Frontiers Jun 4, 2026
Narrative review examines antioxidant metabolites for autism spectrum disorder in children
Drug Pipeline Sys. Review
Narrative review examines antioxidant metabolites for autism spectrum disorder in children Could antioxidant nutrients help children with autism spectrum disorder?
This narrative review evaluates the potential role of antioxidant metabolites from botanical drugs and nutrients, including vitamins E and C…
Antioxidant nutrients like vitamins E and C, plus botanical compounds, may help address oxidative stress linked to autism spectrum disorder …
Frontiers Apr 19, 2026
Intravenous vitamin C did not reduce gastrointestinal toxicities but attenuated platelet decline in nasopharyngeal carcinoma patients
Oncology RCT
Intravenous vitamin C did not reduce gastrointestinal toxicities but attenuated platelet decline in nasopharyngeal carcinoma patients Intravenous vitamin C may help protect platelets during cancer treatment in Thailand
A randomized, double-blind, placebo-controlled trial in Thailand assessed 2 g of intravenous vitamin C prior to chemotherapy in patients wit…
Intravenous vitamin C helped slow platelet loss in Thai cancer patients undergoing treatment, though it did not reduce common side effects l…
Apr 14, 2026
Oxidative stress drives steroid-induced necrosis of femoral head; antioxidants may help maintain redox balance
Orthopedics & Sports Medicine Sys. Review
Oxidative stress drives steroid-induced necrosis of femoral head; antioxidants may help maintain redox balance Why Steroid Pills Can Quietly Starve Your Hip Bone
This systematic review examined the role of oxidative stress and various antioxidant classes in steroid-induced necrosis of the femoral head…
Steroid pills used for asthma and lupus may quietly starve hip bones of blood through oxidative stress, potentially leading to bone death an…
Frontiers Apr 13, 2026
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis
Infectious Disease Meta-analysis
Intravaginal vitamin C may increase short-term cure and prevent recurrence of bacterial vaginosis Intravaginal Vitamin C May Help Treat Bacterial Vaginosis in Nonpregnant Patients
A meta-analysis of 1,107 nonpregnant patients found intravaginal vitamin C (250 mg daily for 6 days) was associated with higher short-term c…
Intravaginal vitamin C cured 66% of bacterial vaginosis patients in short-term trials, outperforming placebo and showing promise against sta…
Apr 9, 2026