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Home › Medications › chlorhexidine gluconate

chlorhexidine gluconate

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of chlorhexidine gluconate

21 trials tracked of chlorhexidine gluconate: 9 in phase 3 or 4 and 1 with published results. The most-cited published study has 10 citations.

21Trials tracked
9Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 7 Phase 2 2 Phase 1 2 Other / NA 8
  1. Phase 3 Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Completed · 10 cited
  2. Phase 4 Evaluation of a Staphylococcus Eradication Protocol for Patients Who Present to the ED With Cutaneous Abscess Completed
  3. Phase 4 BPO vs Hibiclens Soap for Surgical Preparation Completed
  4. Phase 3 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Volunteers Completed
  5. Phase 3 Preoperative CHG Cloth on Healthy Subjects Completed
  6. Phase 3 Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects Completed
Show 15 more trials
  1. Phase 3 Evaluate Clinical Research From Commerical Oral Care Products Completed
  2. Phase 3 Study to Determine the Anti-plaque Efficacy of Commerical Toothpastes and an Oral Rinse Completed
  3. Phase 3 Clinical Performance of a Chlorhexidine Antimicrobial Dressing Completed
  4. Phase 2 Decolonization of the Oropharynx, an Important and Neglected Reservoir of S. Aureus Colonization Completed
  5. Phase 2 Evaluating Safety and Effectiveness of Octenidine Dihydrochloride Completed
  6. Phase 1 Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age Completed
  7. Phase 1 Single Dose CHG Pharmacokinetic Study Completed
  8. N/A Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees Completed
  9. N/A Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent Methicillin-resistant Staphylococcus Aureus & Other Hospital Infections Completed
  10. N/A Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit Completed
  11. N/A A Cluster-randomized Cross-over Trial Evaluating the Comparative Effectiveness of Three Skin Antiseptic Interventions Completed
  12. N/A Checklist to Prevent MRSA Surgical Site Infections Completed
  13. N/A Chlorhexidine Drying Time Completed
  14. N/A Chlorhexidine Gluconate Oral Care for Adults Experiencing Trauma Completed
  15. N/A Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Ozone therapy offers comparable antimicrobial efficacy to chlorhexidine gluconate with lower cytotoxicity in dental applications
Psychiatry Sys. Review
Ozone therapy offers comparable antimicrobial efficacy to chlorhexidine gluconate with lower cytotoxicity in dental applications Ozone therapy matches chlorhexidine for dental germ control
This narrative review explores the use of ozone therapy, including gaseous ozone and ozonated liquids, for oral health care. The authors syn…
Ozone therapy fights dental germs as well as chlorhexidine but with less cell damage, a review finds.
Frontiers Jun 19, 2026
Meta-Analysis Shows No SSI Difference Between Chlorhexidine and Povidone Iodine for Vaginal Antisepsis
OB/GYN & Women's Health Meta-analysis
Meta-Analysis Shows No SSI Difference Between Chlorhexidine and Povidone Iodine for Vaginal Antisepsis Vaginal cleaning with chlorhexidine does not prevent infections better than iodine in major gynecologic surgeries
This systematic review and meta-analysis evaluated vaginal antisepsis in 9538 patients undergoing major gynecologic operations. The analysis…
A large review of nearly 10,000 patients found that using chlorhexidine for vaginal cleaning did not lower infection risk compared to iodine…
medRxiv May 28, 2026