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Pediatrics
RCT
Esketamine vs fentanyl for pediatric tonsillectomy pain shows comparable FLACC scores
Esketamine and fentanyl ease kids' tonsil pain equally after surgery
This randomized controlled trial in 54 children scheduled for tonsillectomy compared esketamine 0.5 mg·kg to fentanyl 4 μg·kg at induction. …
For kids getting tonsils out, esketamine and fentanyl control pain just as well, but esketamine keeps blood pressure steadier during surgery…
Apr 23, 2026
Psychiatry
FDA Approval
FDA Approves Spravato (esketamine) for Treatment-Resistant Depression and Depressive Symptoms with Acute Suicidal Ideation in Adults
The FDA approved a new nasal spray called Spravato for severe depression.
The FDA approved Spravato (esketamine) for treatment-resistant depression in adults as monotherapy or with an oral antidepressant, and for d…
FDA approved a new nasal spray for severe depression when other treatments fail or when patients face acute suicidal thoughts.
FDA
Apr 17, 2026
Psychiatry
Observational study links esketamine-induced mystical experiences to depression improvement in 45 patients
Mystical experiences during esketamine treatment linked to better depression outcomes in small study
In an observational study of 45 patients with treatment-resistant depression receiving esketamine at two centers, 58% experienced mystical e…
Patients with treatment-resistant depression who felt mystical effects from esketamine showed greater improvement, while other side effects …
medRxiv
Apr 3, 2026