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Home › Medications › estradiol

estradiol

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of estradiol

26 trials tracked of estradiol: 8 in phase 3 or 4 and 3 with published results. The most-cited published study has 242 citations.

26Trials tracked
8Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 4 2 Phase 3 6 Phase 2 11 Phase 1 1 Other / NA 6
  1. Phase 3 Perimenopausal Estrogen Replacement Therapy Study Completed · 242 cited
  2. Phase 3 A Safety and Efficacy Study of the Combination Estradiol and Progesterone to Treat Vasomotor Symptoms Completed · 25 cited
  3. Phase 3 Estradiol Vaginal Softgel Capsules in Treating Symptoms of Vulvar and Vaginal Atrophy in Postmenopausal Women Completed · 22 cited
  4. Phase 4 Perimenopausal Effects of Estradiol on Reward Responsiveness Completed
  5. Phase 4 Vaginal Estrogen on Postpartum Atrophy, Perineal Pain, and Sexual Function Completed
  6. Phase 3 A Study Comparing Estradiol Vaginal Cream to Estrace® Cream in Females With Atrophic Vaginitis Completed
Show 20 more trials
  1. Phase 3 Estrogen and Fear in PTSD Completed
  2. Phase 3 Hormone Replacement Therapy for Use in Postmenopausal Women for Relief of Hot Flushes and Urogenital Symptoms. Completed
  3. Phase 2 The Role of Hormones in Postpartum Mood Disorders Completed
  4. Phase 2 Assessment of Functional Status of Estrogen Receptors in Breast Cancer by Positron Emission Tomography Completed
  5. Phase 2 The Effects of Reproductive Hormones on Mood and Behavior Completed
  6. Phase 2 Research Investigation of Soy and Estrogen Completed
  7. Phase 2 Study of Physiological and High Dose Estradiol in the Treatment of Hormone Receptor Positive Metastatic Breast Cancer Completed
  8. Phase 2 Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids Completed
  9. Phase 2 Neurobiology of Bulimia Nervosa Completed
  10. Phase 2 A Definitive Estrogen Patch Study (ADEPT) Completed
  11. Phase 2 Estradiol Levels in Patients Treated With Estring Completed
  12. Phase 2 TXV13-01 Estradiol Vaginal Softgel Capsules in Treating Postmenopausal Women With Symptoms of Vulvar and Vaginal Atrophy Completed
  13. Phase 2 Estrogen Receptor Beta and Mood Completed
  14. Phase 1 Transgender Estradiol Completed
  15. N/A Estrogen Sensitivity and Ovulatory Dysfunction in Obesity Completed
  16. N/A Vascular Mechanisms for the Effects of Loss of Ovarian Hormone Function on Cognition in Women Completed
  17. N/A Relationship Between the Menstrual Cycle and Heart Disease in Women Completed
  18. N/A Fractional CO2 Vaginal LASER Therapy for Recurrent Urinary Tract Infection Completed
  19. N/A Timing Estrogen After MenoPaUSe Completed
  20. N/A Mirena and Estrogen for Control of Perimenopause Symptoms and Ovulation Suppression Completed

Showing the 26 most-cited and recently-updated of 26 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Higher third trimester estradiol levels associated with maternal hypothyroxinemia and lower FT4
Diabetes & Endocrinology Cohort
Higher third trimester estradiol levels associated with maternal hypothyroxinemia and lower FT4 High Estradiol Levels Link to Low Thyroid Hormone in Late Pregnancy
This cohort study of 200 women at 28 weeks gestation or later found that higher estradiol levels were associated with maternal hypothyroxine…
High pregnancy hormones may explain why thyroid hormone drops in late pregnancy without raising TSH levels.
Frontiers Apr 30, 2026
Transdermal Estradiol Patches Show Noninferiority to LHRH Agonists in Prostate Cancer Metastasis-Free Survival
Oncology RCT
Transdermal Estradiol Patches Show Noninferiority to LHRH Agonists in Prostate Cancer Metastasis-Free Survival Men with advanced prostate cancer may have fewer hot flashes with a new patch treatment
This phase 3 randomized trial evaluated 1360 men with locally advanced prostate cancer across 75 U.K.
A new patch for advanced prostate cancer showed similar cancer control to standard shots but caused fewer hot flashes in a large UK trial.
Apr 23, 2026
Systematic review finds no progestogen class effect in oral contraception, with varying safety profiles
Diabetes & Endocrinology Sys. Review
Systematic review finds no progestogen class effect in oral contraception, with varying safety profiles A Safer Pill? How a New Generation of Birth Control May Lower Your Risk
A systematic review of oral contraception in women found no class effect among progestogens.
New birth control pills using natural estrogens may lower blood clot risks compared to older versions, offering a safer option for millions …
Frontiers Apr 12, 2026
Phase 2 trial compares lidocaine/estradiol cream, nortriptyline, and combination for vestibulodynia subtypes
Neurology Phase II
Phase 2 trial compares lidocaine/estradiol cream, nortriptyline, and combination for vestibulodynia subtypes Can a cream or pill help women with chronic pelvic pain?
A 52-month, phase 2, randomized, double-blinded, placebo-controlled trial in 209 women with distinct vestibulodynia subtypes compared 5% lid…
Women with chronic pelvic pain may finally find relief as a new trial compares creams, pills, and combined treatments to personalize care fo…
CT.gov Apr 3, 2026