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Home › Medications › glimepiride

glimepiride

1 published article · Updated continuously

Clinical Trial Landscape

Clinical Trials of glimepiride

54 trials tracked of glimepiride: 46 in phase 3 or 4 and 11 with published results. The most-cited published study has 160 citations.

54Trials tracked
46Phase 3 & 4
0Recruiting
11With published results
Phase distribution
Phase 4 11 Phase 3 35 Phase 2 3 Phase 1 2 Other / NA 3
  1. Phase 3 Safety and Efficacy of Ertugliflozin in the Treatment of Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin (MK-8835-006; VERTIS SITA2) Completed · 160 cited
  2. Phase 3 A Study of the Efficacy and Safety of Ertugliflozin Monotherapy in the Treatment of Participants With Type 2 Diabetes Mellitus and Inadequate Glycemic Control Despite Diet and Exercise (MK-8835-003, VERTIS MONO) Completed · 145 cited
  3. Phase 3 Efficacy and Safety of Ertugliflozin (MK-8835/PF-04971729) With Sitagliptin in the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Diet and Exercise (MK-8835-017) Completed · 87 cited
  4. Phase 4 Efficacy and Safety of Dapagliflozin and Dapagliflozin Plus Saxagliptin in Combination With Metformin in Type 2 Diabetes Patients Compared With Sulphonylurea Completed · 73 cited
  5. Phase 3 A Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Participants With Type 2 Diabetes and Inadequate Glycemic Control on Metformin Monotherapy (MK-8835-012) Completed · 53 cited
  6. Phase 3 CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes Completed · 38 cited
Show 44 more trials
  1. Phase 3 A Study to Assess the Safety and Efficacy of Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (T2DM) and Inadequate Glycemic Control (MK-3102-011) Completed · 16 cited
  2. Phase 4 Dapagliflozin and Measures of Cardiovascular Autonomic Function in Patients With Type 2 Diabetes (T2D) Completed · 15 cited
  3. Phase 3 A Study to Evaluate the Safety, Tolerability, and Efficacy of the Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin Therapy (MK-3102-024) Completed · 15 cited
  4. Phase 4 A Study of the Safety and Efficacy of Glimepiride, Gliclazide, Repaglinide or Acarbose When Added to Sitagliptin + Metformin Combination Therapy in Chinese Participants With Diabetes (MK-0431-313) Completed · 14 cited
  5. Phase 3 A 52-week International, Multicenter Trial With a Long -Term Extension to Evaluate Saxagliptin With Dapagliflozin in Combination With Metformin Compared to Glimepiride in Combination With Metformin in Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin Alone Completed · 13 cited
  6. Phase 4 Study of the Durability of Glycemic Control With Nateglinide Completed
  7. Phase 4 Glycemic Excursions in Type 2 Diabetic Patients With Vildagliptin and Metformin Versus Vildagliptin and Glimepiride Completed
  8. Phase 4 Dietary Impacts on Glucose-lowering Effects of Sitagliptin in Type 2 Diabetes Completed
  9. Phase 4 Foxiga Korea Local Phase 4 Study Completed
  10. Phase 4 Comparison of Biphasic Insulin Aspart 30 Versus Insulin Glargine Both in Combination With Metformin and Glimepiride in Subjects With Type 2 Diabetes Completed
  11. Phase 4 Saxagliptin Compared to Glimepiride in Elderly Type 2 Diabetes Patients, With Inadequate Glycemic Control on Metformin Completed
  12. Phase 4 Comparison of the Blood Sugar Lowering Effect of Biphasic Insulin Aspart 30 and Insulin Glargine Both Combined With Metformin and Glimepiride in Chinese and Japanese Subjects With Type 2 Diabetes New to Insulin Treatment Completed
  13. Phase 4 Insulin Glulisine in Type 2 Diabetic Patients Completed
  14. Phase 3 Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy Completed
  15. Phase 3 Safety and Efficacy of Bexagliflozin Compared to Glimepiride as Add-on Therapy to Metformin in Type 2 Diabetes Subjects Completed
  16. Phase 3 Ranolazine When Added to Glimepiride in Subjects With Type 2 Diabetes Mellitus Completed
  17. Phase 3 A Randomised, db, Placebo-controlled Study of BI 1356 for 18 Weeks Followed by a 34 Week Double-blind Extension Period (Placebo Patients Switched to Glimepiride) in Type 2 Diabetic Patients for Whom Treatment With Metformin is Inappropriate Completed
  18. Phase 3 Efficacy and Safety of Dapagliflozin in Combination With Glimepiride (a Sulphonylurea) in Type 2 Diabetes Patients Completed
  19. Phase 3 Exenatide Versus Glimepiride in Patients With Type 2 Diabetes Completed
  20. Phase 3 Comparison of Two Treatment Regimens (Sitagliptin Versus Liraglutide) on Participants Who Failed to Achieve Good Glucose Control on Metformin Alone (MK-0431-403) Completed
  21. Phase 3 Efficacy Study of Pioglitazone Compared to Glimepiride on Coronary Atherosclerotic Disease Progression in Subjects With Type 2 Diabetes Mellitus Completed
  22. Phase 3 Effect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 Diabetes Completed
  23. Phase 3 Glycemic Control and Complications in Diabetes Mellitus Type 2 (VADT) Completed
  24. Phase 3 Clinical Trial to Evaluate the Safety and Efficacy of the Addition of Sitagliptin in Participants With Type 2 Diabetes Mellitus Receiving Acarbose Monotherapy (MK-0431-130) Completed
  25. Phase 3 Addition of Omarigliptin (MK-3102) to Participants With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Combination Therapy With Glimepiride and Metformin (MK-3102-022) Completed
  26. Phase 3 Efficacy and Safety of BI 1356 in Combination With Metformin in Patients With Type 2 Diabetes Completed
  27. Phase 3 A Study Comparing the Effects and Safety of Dulaglutide With Glimepiride in Type 2 Diabetes Mellitus Completed
  28. Phase 3 Safety and Efficacy of Linagliptin in Type-2-diabetes Mellitus Patients With Moderate to Severe Renal Impairment Completed
  29. Phase 3 Efficacy and Safety of Empagliflozin (BI 10773) With Metformin in Patients With Type 2 Diabetes Completed
  30. Phase 3 CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride Completed
  31. Phase 3 Efficacy and Safety of Albiglutide in Treatment of Type 2 Diabetes Completed
  32. Phase 3 A Study to Determine the Safety and Efficacy of Albiglutide in Subjects With Type 2 Diabetes Completed
  33. Phase 3 Study of How Dulaglutide Compares to Placebo in Participants With Type 2 Diabetes Who Are Also on Sulfonylurea Therapy (AWARD-8) Completed
  34. Phase 3 To Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given Together Completed
  35. Phase 3 The Effect of Liraglutide on Endothelial Function in Subjects With Type 2 Diabetes Mellitus Completed
  36. Phase 3 A Study in China Evaluating the Safety and Efficacy of Adding Sitagliptin to Stable Therapy With Sulfonylurea With or Without Metformin in Participants With Type 2 Diabetes Mellitus (T2DM) (MK-0431-253) Completed
  37. Phase 3 A Study in Participants With Type 2 Diabetes Mellitus (AWARD-2) Completed
  38. Phase 3 Safety and Efficacy of Sitagliptin Compared With Glimepiride in Elderly Participants With Type 2 Diabetes Mellitus (MK-0431-251) Completed
  39. Phase 3 A Study of the Safety and Efficacy of Omarigliptin (MK-3102) Compared With Glimepiride in Participants With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-3102-016) Completed
  40. Phase 3 Efficacy and Safety of Alogliptin Used in Combination With Sulfonylurea in Participants With Type 2 Diabetes in Japan Completed
  41. Phase 2 Study To Understand Efficacy And Safety Of Investigational Agent (PF-04937319) Compared To Approved Agent (Glimepiride) In Patients With Diabetes On Metformin Completed
  42. Phase 2 Efficacy and Safety of BI 1356 BS (Linagliptin) in Combination With Metformin in Patients With type2 Diabetes Completed
  43. Phase 2 A Study to Test MK-0941 in Patients With Type 2 Diabetes Mellitus With Inadequate Glycemic Control on Metformin (MK-0941-017) Completed
  44. Phase 1 Trial to Assess the Influence of 4 Weeks' Treatment With Linagliptin as Compared to Glimepiride and Placebo on Endothelial Function in Patients With Type 2 Diabetes Using FMD (Flow-Mediated Vasodilation) Completed

Showing the 50 most-cited and recently-updated of 54 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Sitagliptin and liraglutide superior for CGM targets in type 2 diabetes
Nutrition & Obesity Medicine RCT
Sitagliptin and liraglutide superior for CGM targets in type 2 diabetes Two diabetes drugs outperform others in long-term glucose control
This randomized trial compared adding sitagliptin, liraglutide, glimepiride, or insulin glargine to metformin in 1,080 participants with typ…
A five-year trial shows sitagliptin and liraglutide offer better glucose stability and safety than glimepiride or insulin glargine for peopl…
Diab Care Jun 1, 2026