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Home › Medications › Lithium

Lithium

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of Lithium

21 trials tracked of Lithium: 12 in phase 3 or 4 and 4 with published results. The most-cited published study has 29 citations.

21Trials tracked
12Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 8 Phase 3 4 Phase 2 4 Other / NA 5
  1. Phase 4 Sequential Multiple Assignment Treatment for Bipolar Disorder Completed · 29 cited
  2. Phase 4 Cost- Effectiveness and Quality of Life Assessment in Mood Disorder Completed · 6 cited
  3. Phase 4 Cost- Effectiveness and Quality of Life Assessment in Major Depression Disorder Completed · 6 cited
  4. Phase 3 Treatment of Mania Symptoms With Drug Therapy Completed
  5. Phase 4 FMRI Study of Brain Response Before and After Lithium Treatment in People With Bipolar Disorder Completed
  6. Phase 4 Comparative Effectiveness Study for Bipolar Disorder Completed
Show 15 more trials
  1. Phase 4 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed
  2. Phase 4 Adult Bipolar Mania Completed
  3. Phase 4 Paliperidone and Lithium in the Treatment of Suicidality - Treatment Indication and Epigenetic Regulation Completed
  4. Phase 3 Efficacy and Safety of Olanzapine in the Extended Treatment for Manic or Mixed Episode of Bipolar I Disorder Completed
  5. Phase 3 Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder Completed
  6. Phase 3 Study to Evaluate the Efficacy and Safety of Aripiprazole Administered With Lithium or Valproate Over 12 Weeks in the Treatment of Mania in Bipolar I Disorder Completed
  7. Phase 2 A Pilot Trial of Lithium in Subjects With Progressive Supranuclear Palsy or Corticobasal Degeneration Completed
  8. Phase 2 Treatment of Psychosis and Agitation in Alzheimer's Disease Completed
  9. Phase 2 Effect of Lithium Therapy on Long COVID Symptoms Completed
  10. Phase 2 Ketamine Plus Lithium in Treatment-Resistant Depression Completed
  11. N/A PET and MRI Brain Imaging of Bipolar Disorder Completed
  12. N/A Wake Therapy in the Treatment of Depression Completed
  13. N/A Preventing Relapse After Successful Electroconvulsive Therapy for Depression Completed
  14. N/A Decision-Making in Bipolar Disorder Completed
  15. N/A Trial of Lithium Carbonate for Treatment of Osteoporosis-pseudoglioma Syndrome Completed

Showing the 21 most-cited and recently-updated of 21 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Second-generation antipsychotics show higher response rates than placebo for augmenting major depressive disorder
Psychiatry Meta-analysis
Second-generation antipsychotics show higher response rates than placebo for augmenting major depressive disorder Antipsychotics show promise in treating major depressive disorder
This meta-analysis of 13,616 adults with major depressive disorder evaluated pharmacological augmentation with lithium, triiodothyronine (T3…
Adding specific antipsychotic medications to treatment plans may help adults with major depressive disorder achieve better results than a pl…
Jul 31, 2026
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents
Psychiatry Meta-analysis
Systematic review and meta-analysis of mood stabilizers for nonsuicidal self-injury in adolescents Mood stabilizers show promise for teen self-injury and depression in China
This systematic review and meta-analysis examined nine studies from China involving adolescent patients with nonsuicidal self-injury. The au…
A review of nine studies suggests mood stabilizers may help reduce self-injury and depression in Chinese adolescents, offering new options f…
May 20, 2026