Mode
Home
Research
Clinical Trials Drug Pipeline Weekly Digests
Reference
Conditions Medications
Community
Questions
Text Size
Log in / Sign up
Home › Medications › memantine

memantine

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of memantine

61 trials tracked of memantine: 33 in phase 3 or 4 and 8 with published results. The most-cited published study has 959 citations.

61Trials tracked
33Phase 3 & 4
0Recruiting
8With published results
Phase distribution
Phase 4 21 Phase 3 12 Phase 2 19 Phase 1 1 Other / NA 8
  1. Phase 3 Memantine in Preventing Side Effects in Patients Undergoing Whole-Brain Radiation Therapy for Brain Metastases From Solid Tumors Completed · 959 cited
  2. Phase 3 Memantine Hydrochloride and Whole-Brain Radiotherapy With or Without Hippocampal Avoidance in Reducing Neurocognitive Decline in Patients With Brain Metastases Completed · 851 cited
  3. Phase 4 Memantine Effects on Sensorimotor Gating and Neurocognition in Schizophrenia Completed · 172 cited
  4. Phase 3 Memantine Treatment for Obsessive-compulsive Disorder and Generalized Anxiety Disorder Completed · 91 cited
  5. Phase 4 Memantine Treatment for Improving Rehabilitation Outcomes and Preventing Depression in Older Adults Completed · 63 cited
  6. Phase 4 Brain Aging and Treatment Response in Geriatric Depression Completed · 62 cited
Show 44 more trials
  1. Phase 3 Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder Completed · 46 cited
  2. Phase 4 Monitoring Anti-Dementia Drugs by Serum Levels Completed
  3. Phase 4 Memantine and Comprehensive, Individualized Management of Alzheimer's Disease and Caregiver Training Completed
  4. Phase 4 Memantine and Cognitive Dysfunction in Bipolar Disorder Completed
  5. Phase 4 Study of Memantine to Treat Huntington's Disease Completed
  6. Phase 4 Namenda (Memantine) for Non-motor Symptoms in Parkinson's Disease Completed
  7. Phase 4 Biomarker Predictors of Memantine Sensitivity in Patients With Alzheimer's Disease Completed
  8. Phase 4 Delaying the Progression of Driving Impairment in Individuals With Mild Alzheimer's Disease Completed
  9. Phase 4 Memantine Augmentation of Lamotrigine Incomplete-Response in Bipolar Depression Completed
  10. Phase 4 Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease Completed
  11. Phase 4 Memantine Augmentation of Antidepressants Completed
  12. Phase 4 Memantine (10mg BID) for the Frontal and Temporal Subtypes of Frontotemporal Dementia Completed
  13. Phase 4 Effects of Memantine on Magnetic Resonance (MR) Spectroscopy in Subjects at Risk for Alzheimer's Disease Completed
  14. Phase 4 A Clinical Study Evaluating the Effects of Memantine on Brain Atrophy in Patients With Alzheimer's Disease Completed
  15. Phase 4 A Study of Memantine Hydrochloride (Namenda®) for Cognitive and Behavioral Impairment in Adults With Autism Spectrum Disorders Completed
  16. Phase 4 Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome Completed
  17. Phase 4 Open-Label Pilot Study of Namenda in Adult Subjects With ADHD and ADHD NOS Completed
  18. Phase 4 Effect of Memantine on Functional Communication in Patients With Alzheimer's Disease Completed
  19. Phase 4 Memantine for Spasticity in MS Patients Completed
  20. Phase 3 The Effect of Memantine on Brain Structure and Chemistry in Alzheimer's Disease Patients Completed
  21. Phase 3 Evaluation of Memantine Versus Placebo on Ischemic Stroke Outcome Completed
  22. Phase 3 Comparative Study Between Valproate and Memantine in the Prophylactic Management of Episodic Migraine. Completed
  23. Phase 3 Memantine Augmentation of Targeted Cognitive Training in Schizophrenia Completed
  24. Phase 3 Memantine Plus Es-citalopram in Elderly Depressed Patients With Cognitive Impairment Completed
  25. Phase 3 Memantine-enhanced Buprenorphine Treatment for Opioid-dependent Young Adults Completed
  26. Phase 3 Memantine as a Supplement to Naltrexone in Treating Heroin Dependence Completed
  27. Phase 3 A Randomized, Clinical Trial of Vitamin E and Memantine in Alzheimer's Disease Completed
  28. Phase 2 Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder Completed
  29. Phase 2 Effectiveness of Memantine in Treating Cocaine-Dependent Individuals - 2 Completed
  30. Phase 2 Memantine and Naltrexone Treatment for Opioid Dependence Completed
  31. Phase 2 SUVN-502 With Donepezil and Memantine for the Treatment of Moderate Alzheimer's Disease- Phase 2a Study Completed
  32. Phase 2 Memantine in Body Focused Repetitive Behaviors Completed
  33. Phase 2 Down Syndrome Memantine Follow-up Study Completed
  34. Phase 2 Functional Neuroimaging of Alcoholism Vulnerability (PIT) Completed
  35. Phase 2 Memantine Hydrochloride in Helping Cancer Survivors Stop Smoking Completed
  36. Phase 2 Open-label Study of Safety and Tolerability of Memantine in Children With Autism Completed
  37. Phase 2 Therapy in Amyotrophic Lateral Sclerosis (TAME) Completed
  38. Phase 2 Memantine Treatment of Compulsive Buying Completed
  39. Phase 2 Family History Study of Alcohol Consumption Using Memantine Completed
  40. Phase 2 Memantine in the Treatment of Kleptomania Completed
  41. Phase 2 Biomarker Strategies for Medication-Enhanced Cognitive Training in Schizophrenia Completed
  42. Phase 2 Memantine Augmentation in Obsessive-Compulsive Disorder Completed
  43. Phase 2 Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine Completed
  44. Phase 2 Memantine Treatment Study of Pathological Gambling Completed

Showing the 50 most-cited and recently-updated of 61 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Glutamatergic agents show preclinical promise in Multiple Sclerosis but fail in clinical trials
Neurology Sys. Review
Glutamatergic agents show preclinical promise in Multiple Sclerosis but fail in clinical trials Laboratory tests show promise for multiple sclerosis but face hurdles
This narrative review examines the efficacy of glutamatergic agents in experimental autoimmune encephalomyelitis models versus human clinica…
Certain drugs showed success in lab models for multiple sclerosis, but these same medicines failed to work during actual human clinical tria…
Frontiers Aug 11, 2026
Memantine improved neuropathy severity and pain scores versus placebo in CIPN over eight weeks
Oncology RCT
Memantine improved neuropathy severity and pain scores versus placebo in CIPN over eight weeks Memantine eased nerve pain and tingling for chemotherapy patients in eight weeks
This randomized clinical trial enrolled 176 individuals with chemotherapy-induced peripheral neuropathy.
A new trial found memantine significantly reduced nerve pain and tingling in chemotherapy patients compared to placebo over eight weeks.
Apr 29, 2026
Memantine reduced PAC burden and new-onset AF in a Phase 2 randomized trial of 241 adults
Cardiology RCT
Memantine reduced PAC burden and new-onset AF in a Phase 2 randomized trial of 241 adults Common Heart Flutters May Be Linked to Brain Drug
In this Phase 2 randomized, double-blind, placebo-controlled trial of 241 symptomatic adults with frequent PACs (≥1000/24 h), memantine show…
A new study shows a brain medication may calm frequent heart flutters and lower the risk of more serious heart rhythm problems.
Apr 22, 2026
Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery
Anesthesiology & Pain Medicine RCT
Memantine reduces opioid use but not pain in knee osteoarthritis patients after surgery This Common Memory Drug Cuts Opioid Use After Knee Replacement
A randomized controlled trial in adults with knee osteoarthritis found memantine did not significantly lower pain scores versus placebo, but…
A drug already approved for Alzheimer's disease may help knee replacement patients rely less on opioids during recovery — even if it does no…
Apr 14, 2026