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Home › Medications › methadone

methadone

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of methadone

27 trials tracked of methadone: 14 in phase 3 or 4 and 4 with published results. The most-cited published study has 121 citations.

27Trials tracked
14Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 11 Phase 3 3 Phase 2 7 Phase 1 2 Other / NA 4
  1. Phase 4 Starting Treatment With Agonist Replacement Therapies (START) Completed · 121 cited
  2. Phase 3 Improving Outcomes in Neonatal Abstinence Syndrome Completed · 99 cited
  3. Phase 4 Buprenorphine and Methadone for Opioid-dependent Chronic Back Pain Patients Completed · 47 cited
  4. Phase 4 Morphine Versus Methadone for Opiate Exposed Infants With Neonatal Abstinence Syndrome Completed · 35 cited
  5. Phase 4 Methadone and Hydromorphone For Spinal Surgery Completed
  6. Phase 4 Methadone Versus Morphine for Orthopedic Surgery Patients Completed
Show 21 more trials
  1. Phase 4 Comparison Between Methadone and Morphine for Neonatal Opiate Withdrawal Completed
  2. Phase 4 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Completed
  3. Phase 4 Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement) Completed
  4. Phase 4 The Effect of Choice of Intraoperative Opioid on Postoperative Pain Completed
  5. Phase 4 Treatment of Neonatal Abstinence Syndrome Completed
  6. Phase 4 Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients Completed
  7. Phase 3 Perioperative Methadone Use to Decrease Opioid Requirement in Pediatric Spinal Fusion Patients Completed
  8. Phase 3 RCT Comparing Methadone and Buprenorphine in Pregnant Women Completed
  9. Phase 2 Measuring the Amount of Methadone or Morphine in the Blood of Neonates, Infants & Children After Cardiac Surgery. Completed
  10. Phase 2 Gabapentin, Methadone, and Oxycodone With or Without Venlafaxine Hydrochloride in Managing Pain in Participants With Stage II-IV Squamous Cell Head and Neck Cancer Undergoing Chemoradiation Therapy Completed
  11. Phase 2 Pediatric Pain Optimization After Tonsillectomy Completed
  12. Phase 2 Comparison of A Single Dose Combination of Methadone and Morphine With Morphine Alone for Treating Post-operative Pain Completed
  13. Phase 2 Pharmacotherapy & CM for Opioid and Cocaine Dependence Completed
  14. Phase 2 Pharmacogenetics of Disulfiram for Cocaine Completed
  15. Phase 2 Methadone vs Magnesium in Spinal Fusion Completed
  16. Phase 1 Effects of Doravirine (MK-1439) on Methadone Pharmacokinetics in Methadone-Maintained Participants (MK-1439-045) Completed
  17. Phase 1 A Study to Evaluate the Pharmacokinetic Effect of SCH 503034 (Boceprevir) on Methadone or Buprenorphine/Naloxone Plasma Concentrations (P08123) Completed
  18. N/A A Randomized Trial of Interim Methadone and Patient Navigation Initiated in Jail Completed
  19. N/A Methadone in Pediatric and Adult Sickle Cell Patients Completed
  20. N/A Methadone in Ambulatory Surgery Completed
  21. N/A Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis Completed

Showing the 27 most-cited and recently-updated of 27 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women
Anesthesiology & Pain Medicine Meta-analysis
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women Buprenorphine-based therapies reduce neonatal abstinence syndrome risk compared to methadone in pregnant women
This systematic review and meta-analysis evaluated buprenorphine-based therapies and methadone in pregnant opioid-dependent women.
A large review of 5,524 pregnant women found babies exposed to buprenorphine had lower rates of withdrawal symptoms and needed less medicati…
May 1, 2026
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients
Psychiatry Cohort
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients Combining buprenorphine and therapy boosts remission rates for opioid dependence
This retrospective cohort study analyzed 18,047 adults aged 18–45 with opioid dependence across 112 U.S.
In a large study, pairing buprenorphine with psychotherapy showed the strongest link to remission from opioid use disorder compared to no tr…
Frontiers Apr 28, 2026
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults
Orthopedics & Sports Medicine RCT
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults Can a single dose of methadone during hip surgery reduce painkiller needs?
In this randomized trial of 129 patients aged 60 or older undergoing hip fracture surgery, a single intraoperative dose of methadone (0.10 m…
A single methadone dose during hip surgery cuts early morphine use but keeps older patients in the hospital longer than those given a placeb…
Apr 17, 2026
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy
Anesthesiology & Pain Medicine RCT
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy Small study tests brain stimulation and AI for opioid addiction in men
A small RCT in 36 male methadone maintenance patients and 24 healthy controls found that active tDCS groups showed significant craving reduc…
A machine learning algorithm identified opioid addiction with 94.3% accuracy in a small study, and brain stimulation reduced cravings in men…
Apr 2, 2026