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Psychiatry
Cohort
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients
Combining buprenorphine and therapy boosts remission rates for opioid dependence
This retrospective cohort study analyzed 18,047 adults aged 18–45 with opioid dependence across 112 U.S. health systems. The combination of …
In a large study, pairing buprenorphine with psychotherapy showed the strongest link to remission from opioid use disorder compared to no tr…
Frontiers
Apr 28, 2026
Orthopedics & Sports Medicine
RCT
Intraoperative methadone alters 72-hour postoperative morphine use after hip fracture surgery in older adults
Can a single dose of methadone during hip surgery reduce painkiller needs?
In this randomized trial of 129 patients aged 60 or older undergoing hip fracture surgery, a single intraoperative dose of methadone (0.10 m…
A single methadone dose during hip surgery cuts early morphine use but keeps older patients in the hospital longer than those given a placeb…
Apr 17, 2026
Anesthesiology & Pain Medicine
RCT
tDCS shows craving reduction in male methadone patients; machine learning algorithm achieves 94% diagnostic accuracy
Small study tests brain stimulation and AI for opioid addiction in men
A small RCT in 36 male methadone maintenance patients and 24 healthy controls found that active tDCS groups showed significant craving reduc…
A machine learning algorithm identified opioid addiction with 94.3% accuracy in a small study, and brain stimulation reduced cravings in men…
Apr 2, 2026