Research across Opioid Use Disorder
Related studies from across the Opioid Use Disorder family.
19 genome-wide significant loci identify genetic architecture and high correlations with other substance use disorders
Genes linked to stimulant addiction found in largest study yet
This meta-analysis of 709,369 individuals identifies 19 genome-wide significant loci associated with Stimulant Use Disorder. The study also …
Scientists found 19 genetic regions tied to stimulant addiction, including one linked to obesity. The study of over 700,000 people also show…
High-dose buprenorphine induction protocol for Opioid Use Disorder in emergency department settings
New plan to test high-dose buprenorphine for opioid use disorder
This randomized clinical trial protocol describes a plan to evaluate high-dose buprenorphine induction for patients with moderate-to-severe …
A new clinical trial plans to see if higher doses of buprenorphine can help more people with opioid use disorder start treatment in the emer…
Nicotinic partial agonists show no effect on opioid use in HIV-positive smokers
New data on nicotine treatment for HIV patients who use opioids
This secondary analysis of a randomized trial in 97 HIV-positive smokers with risky alcohol use and baseline opioid use found no significant…
A new look at nicotine treatment for HIV patients who use opioids found no difference in opioid use between two drug groups.
Protocol for Systematic Review and Meta-Analysis of Dopaminergic Measures in Opioid Use Disorder
Opioid addiction changes brain chemistry in lasting ways
This publication outlines a protocol for a systematic review and meta-analysis investigating dopaminergic measures in adults with opioid use…
People with opioid addiction have clear changes in brain chemistry that may explain why cravings persist, even after stopping use, and could…
Meta-analysis shows methadone exposure linked to higher NAS incidence and treatment needs versus buprenorphine in pregnant women
Buprenorphine-based therapies reduce neonatal abstinence syndrome risk compared to methadone in pregnant women
This systematic review and meta-analysis evaluated buprenorphine-based therapies and methadone in pregnant opioid-dependent women.
A large review of 5,524 pregnant women found babies exposed to buprenorphine had lower rates of withdrawal symptoms and needed less medicati…
Combination buprenorphine and psychotherapy linked to highest remission rates in opioid dependence patients
Combining buprenorphine and therapy boosts remission rates for opioid dependence
This retrospective cohort study analyzed 18,047 adults aged 18–45 with opioid dependence across 112 U.S.
In a large study, pairing buprenorphine with psychotherapy showed the strongest link to remission from opioid use disorder compared to no tr…
Peer navigators provide direct, informational, and facilitation support for OUD during community re-entry
What kind of help do people need most when leaving jail with opioid addiction?
A Connecticut RCT sub-study of 108 criminal legal-involved adults with OUD characterized peer navigator support during community re-entry.
When leaving jail, opioid recovery hinges on practical help like rides to appointments and paperwork support, not just medical advice.
Pilot study examines salivary adiponectin receptor expression in opioid-exposed neonates
How does a mother's opioid use affect her baby's growth signals?
This observational pilot cohort compared salivary adiponectin receptor 1 expression and growth measurements in neonates born at ≥34 weeks' g…
Doctors are investigating how a mother's opioid use during pregnancy might change a newborn's growth signals and body fat levels.
Report estimates state-level economic costs of opioid use disorder and fatal overdose
Report estimates state-level economic costs of opioid use disorder and overdose
A report estimated state-level economic costs of opioid use disorder and fatal opioid overdose in the United States.
A new report estimates the economic costs of opioid use disorder and fatal overdoses for every state in the United States in 2017.
Naloxone prescriptions from US retail pharmacies increased substantially from 2012 to 2018
Did naloxone access improve? Pharmacy prescriptions more than doubled in one year
An observational report of naloxone dispensing trends in US retail pharmacies found the number of prescriptions increased substantially from…
Naloxone prescriptions at U.S. retail pharmacies more than doubled from 2017 to 2018, showing a major jump in access to this life-saving ove…
Report describes overdose education and naloxone distribution programs in U.S. syringe service programs
How do syringe programs teach people to stop overdoses?
A report describes overdose education and naloxone distribution (OEND) programs within syringe service programs in the United States.
A new report looks at how syringe service programs across the U.S.
In adult ED encounters, clinician engagement with EHR-based SDOH data was rare but higher in opioid use disorder cases
Did reviewing social data in the ER actually change how doctors treated opioid use disorder patients?
This cross-sectional study of 17,103 adult emergency department encounters examined clinician engagement with electronic health record-based…
Doctors reviewed social data more often for opioid use disorder patients, yet this action did not increase medication treatments or fix raci…