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Home › Medications › sacubitril/valsartan

sacubitril/valsartan

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of sacubitril/valsartan

6 trials tracked of sacubitril/valsartan: 6 in phase 3 or 4 and 4 with published results. The most-cited published study has 157 citations.

6Trials tracked
6Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 1 Phase 3 5
  1. Phase 3 A Randomized, Double-blind Controlled Study Comparing LCZ696 to Medical Therapy for Comorbidities in HFpEF Patients Completed · 157 cited
  2. Phase 3 The Effects of Sacubitril/Valsartan Compared to Valsartan on LV Remodelling in Asymptomatic LV Systolic Dysfunction After MI Completed · 61 cited
  3. Phase 3 Changes in NT-proBNP, Safety, and Tolerability in HFpEF Patients With a WHF Event (HFpEF Decompensation) Who Have Been Stabilized and Initiated at the Time of or Within 30 Days Post-decompensation (PARAGLIDE-HF) Completed · 25 cited
  4. Phase 4 Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With CCC Completed · 14 cited
  5. Phase 3 Open-label Extension Study to Evaluate Long-term Safety of Sacubitril/Valsartan in Pediatric Patients With HF Completed
  6. Phase 3 A Safety Study of Sacubitril/Valsartan in Japanese Pediatric Patients With Heart Failure Due to Systemic Left Ventricle Systolic Dysfunction Who Have Completed CLCZ696B2319E1 Study Completed

Showing the 6 most-cited and recently-updated of 6 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Sacubitril/Valsartan plus RFCA improves rhythm control in hypertensive NPAF patients
Cardiology RCT
Sacubitril/Valsartan plus RFCA improves rhythm control in hypertensive NPAF patients ARNI plus RFCA improves heart rhythm control in hypertension patients
This randomized controlled trial in 240 hypertensive patients with nonparoxysmal atrial fibrillation compared sacubitril/valsartan plus radi…
Adding sacubitril/valsartan to a heart procedure helped more patients stay in normal rhythm and lowered blood pressure markers.
May 2, 2026
PRISMA Scoping Review Examines Food-Drug Interactions in Cardiovascular and Diabetic Medications
Drug Pipeline Sys. Review
PRISMA Scoping Review Examines Food-Drug Interactions in Cardiovascular and Diabetic Medications Meals May Not Matter for Most New Heart and Diabetes Pills
This PRISMA scoping review synthesized data from 36 publications regarding food-drug interactions in cardiovascular and diabetic medications…
Most new heart and diabetes pills work the same whether you take them with food or on an empty stomach, but a few still need timing.
Frontiers Apr 27, 2026
AI-Based Adjudication of MACE Events Shows High Agreement with Human CEC in MI Trial
Cardiology RCT
AI-Based Adjudication of MACE Events Shows High Agreement with Human CEC in MI Trial AI Can Spot Heart Attacks and Strokes in Medical Records—But Should We Trust It?
This randomized trial compared an AI-based adjudication system (Auto-MACE) to physician CEC adjudication for MACE events in 5,661 patients w…
This new AI tool could speed up medical research by automatically checking medical records for heart problems, saving doctors hundreds of ho…
Apr 23, 2026
Sacubitril/valsartan shows greater LVMI regression than some antihypertensives in hypertension with remodeling
Cardiology Meta-analysis
Sacubitril/valsartan shows greater LVMI regression than some antihypertensives in hypertension with remodeling New Drug Shrinks Heart Muscle Better Than Old Options
A network meta-analysis of 851 patients with essential hypertension and cardiovascular remodeling found sacubitril/valsartan achieved greate…
A new analysis shows one specific medicine shrinks thickened heart muscle better than older blood pressure treatments, offering hope for rev…
Frontiers Apr 14, 2026