INSTI switching linked to higher metabolic risk in people with HIV
Switching HIV meds raises diabetes risk but not heart attack danger
A global cohort study found that switching to integrase inhibitors increased risks for obesity, diabetes, and hypertension, but not MACE, ov…
Switching HIV medication to a newer class may raise the risk of diabetes and weight gain, but it does not appear to increase the risk of hea…
Mendelian Randomization review links Lp(a) to inflammatory protein pathways
Lp(a) may influence heart disease through inflammation pathways
This Mendelian Randomization analysis identifies 521 proteins associated with Lp(a) and 91 downstream proteins in MACE-relevant pathways.
Genetic analysis links Lp(a) to 521 proteins and inflammation pathways that could affect heart disease risk, offering a new mechanistic insi…
Federated meta-analysis validates HEART score performance for chest pain risk stratification in EDs
Federated HEART score analysis shows consistent chest pain risk prediction across six emergency departments
A retrospective multicenter observational study of 57,906 ED encounters found that a federated diagnostic meta-analysis approach for the HEA…
A federated analysis of the HEART score predicts chest pain risks just as accurately as centralizing patient data across six emergency depar…
Polypharmacy and age predict MACE in rural Montana type 2 diabetes cohort
In rural diabetes care, does taking more medications signal higher heart risk?
An observational cohort study of 591 type 2 diabetes patients in rural Montana found medication count and age were significant predictors of…
In rural Montana, patients with type 2 diabetes taking more medications faced higher risks of heart attacks, strokes, and kidney or nerve da…
Bariatric surgery associated with lower cardiovascular risks than GLP-1RA therapy in adults with obesity
Study finds bariatric surgery linked to lower heart risks than GLP-1 drugs in adults with obesity
A meta-analysis of observational studies including 39,569 adults with obesity found bariatric surgery was associated with lower risks of mor…
Adults with obesity who had bariatric surgery faced lower risks of death and heart failure than those taking GLP-1 drugs like Wegovy.
High albumin-corrected anion gap linked to increased MACE risk in CKD patients after PCI
Study links higher blood gap measure to more heart problems in kidney disease patients
A retrospective cohort study of 973 chronic kidney disease patients undergoing percutaneous coronary intervention found that a high albumin-…
Higher levels of a specific blood marker found in kidney disease patients are linked to more heart attacks, strokes, and heart-related death…
MAPSE Predicts Adverse Events in Acute Myocarditis; Lateral MAPSE Shows Superior Performance
Could a simple heart measurement predict serious risks in myocarditis patients?
In a cohort of 46 acute myocarditis patients, reduced MAPSE was linked to major adverse cardiovascular events (MACE). Lateral MAPSE had a hi…
A simple heart measurement called MAPSE predicts serious risks and death in patients with acute myocarditis, helping doctors identify those …
Questions about Major Adverse Cardiovascular Events
Can the HEART score help predict the risk of Major Adverse Cardiovascular Events in the emergency room?
Yes, the HEART score is validated to predict 30-day major adverse cardiovascular events in emergency department chest pain patients, with high specificity and negative predictive value.
Full answer →Does switching HIV medication to an integrase inhibitor raise the risk of Major Adverse Cardiovascular Events?
Yes, switching to an integrase inhibitor may raise the risk of major adverse cardiovascular events, especially in people with low-to-moderate baseline risk, according to a 2024 study.
Full answer →