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Home › Medications › sodium bicarbonate

sodium bicarbonate

2 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of sodium bicarbonate

14 trials tracked of sodium bicarbonate: 7 in phase 3 or 4 and 2 with published results. The most-cited published study has 134 citations.

14Trials tracked
7Phase 3 & 4
0Recruiting
2With published results
Phase distribution
Phase 4 3 Phase 3 4 Phase 2 3 Phase 1 1 Other / NA 3
  1. Phase 3 Sodium Bicarbonate Supplementation in Chronic Kidney Disease Evaluation of Dose Response, Safety and Beneficial Effects Completed · 134 cited
  2. Phase 3 Alkali Therapy in Chronic Kidney Disease Completed · 96 cited
  3. Phase 4 Effect of Urinary Alkalinization on Urine Uric Acid Precipitation and Crystallization in Adults With Type 1 Diabetes Completed
  4. Phase 4 Prevention of Contrast-Induced Nephropathy With Sodium Bicarbonate Bolus Injection Completed
  5. Phase 4 Comparison of Pain of Conventional to Buffered Local Anesthesia During Injection in Pediatric Dental Patients Completed
  6. Phase 3 Sodium Bicarbonate for Prevention of Contrast-Induced Nephropathy Completed
Show 8 more trials
  1. Phase 3 A Pharmacodynamic Study Comparing Zegerid® and Prilosec OTC® (CL2007-17 )(P07813)(COMPLETED) Completed
  2. Phase 2 Bicarbonate in Patients With Out-of-hospital Cardiac Arrest Completed
  3. Phase 2 Use of Bicarbonate to Reduce the Incidence of Acute Renal Failure After Cardiac Surgery Completed
  4. Phase 2 Prevention of Acute Kidney Injury in Cardiac Surgery Patients Completed
  5. Phase 1 A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese Participants Completed
  6. N/A Investigations of the Optimum Serum Bicarbonate Level in Renal Disease. Completed
  7. N/A Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease Completed
  8. N/A Bicarbonate Administration in CKD Completed

Showing the 14 most-cited and recently-updated of 14 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Acute sodium bicarbonate ingestion provides small beneficial effect on HIIE performance in team-sport athletes
Orthopedics & Sports Medicine Meta-analysis
Acute sodium bicarbonate ingestion provides small beneficial effect on HIIE performance in team-sport athletes Sodium bicarbonate may offer small gains for team sport athletes
This meta-analysis of 241 athletes found that acute sodium bicarbonate ingestion results in a small beneficial effect on HIIE performance (H…
Taking sodium bicarbonate before high intensity exercise may provide a small performance boost for team sport athletes, though results are n…
Frontiers Sep 11, 2026
Network meta-analysis of sodium bicarbonate, cholecalciferol, and protein supplementation in 2,879 chronic kidney disease patients
Nutrition & Obesity Medicine Meta-analysis
Network meta-analysis of sodium bicarbonate, cholecalciferol, and protein supplementation in 2,879 chronic kidney disease patients Sodium bicarbonate, vitamin D, and protein may help chronic kidney disease patients
This systematic review and network meta-analysis evaluated sodium bicarbonate, cholecalciferol, and protein supplementation in 2,879 patient…
Vitamin D builds muscle, sodium bicarbonate boosts albumin, and protein lowers phosphorus in chronic kidney disease patients, with protein s…
Frontiers Apr 8, 2026