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Psychiatry
Meta-analysis
No significant association between BDNF genotypes and remission in major depressive disorder patients treated with antidepressants
Genetic markers do not predict antidepressant success in major depression
This meta-analysis review examined 599 Caucasian patients with a major depressive episode treated with SSRIs, SNRIs, or TCAs. The analysis f…
A large review found that specific genetic markers do not predict who will recover from depression when taking common antidepressant medicat…
Jun 1, 2026
Genetics & Precision Medicine
RCT
Genotype-Guided SSRI Prescribing Shows No Short-Term Benefit but Higher Remission at 6 Months
Genetic Testing Helps Some Depression Patients Feel Better Long Term
This randomized clinical trial compared genotype-guided SSRI prescribing to usual care in 1460 patients with depression. At 3 months, there …
• Genetic-guided SSRI prescriptions boost six-month remission rates for certain patients • Helps people with specific gene variations affect…
May 6, 2026
Genetics & Precision Medicine
Meta-analysis
Meta-analysis identifies two genomic loci associated with antidepressant non-response in 135,471 individuals
Why do antidepressants fail for some people? New genetic clues emerge
A genome-wide association meta-analysis of 135,471 individuals prescribed antidepressants identified two novel genomic loci associated with …
Millions struggle to find working antidepressants, but new genetic data reveals why some fail and suggests other drug options for treatment …
Apr 2, 2026