Mode
Text Size
Log in / Sign up

Sudden Cardiac Death

Part of Cardiac Arrest

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sudden Cardiac Death

23 trials tracked for Sudden Cardiac Death: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 170 citations.

23Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 1 1 Other / NA 19
  1. Phase 3 Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging Completed · 170 cited
  2. Phase 4 'Effect of CRT on Defibrillation Threshold Estimates' Study Completed
  3. Phase 4 POWER (Pulse Width Optimized Waveform Evaluation Trial) Completed
  4. Phase 1 Automatic External Defibrillation Monitoring in Cardiac Arrest Completed
  5. N/A Heart Failure and Sudden Cardiac Death Japan Registry Completed
  6. N/A Extracellular Matrix Marker of Arrhythmia Risk (EMMA) Completed
Show 17 more trials
  1. N/A Same Day Subcutaneous ICD And Send Home (DASH) Completed
  2. N/A Assessment of Primary Prevention Patients Receiving An ICD - Systematic Evaluation of ATP Completed
  3. N/A Educational Videos to Address Racial Disparities in Implantable Cardioverter Defibrillator Therapy Completed
  4. N/A Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest Completed
  5. N/A SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients Completed
  6. N/A Optimization of VNS in Epileptic Patients to Induce Cardioprotection Completed
  7. N/A Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). Completed
  8. N/A DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed
  9. N/A LifeVest Safety and Efficacy in Real Life Settings in France Completed
  10. N/A Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 ) Completed
  11. N/A Heart Rate Response to Regadenoson and Sudden Cardiac Death Completed
  12. N/A Next Generation INCEPTA Implantable Cardioverter Defibrillator (ICD) and Cardiac Resynchronization Therapy (CRT-D) Field Following Study Completed
  13. N/A Heart Failure Optimization Study Completed
  14. N/A ASSURE WCD Clinical Evaluation - Conversion Efficacy Study Completed
  15. N/A REASSURE AV Registry Completed
  16. N/A SAFEty of Two Strategies of ICD Management at Implantation Completed
  17. N/A ECPR for Refractory Out-Of-Hospital Cardiac Arrest Completed

Showing the 23 most-cited and recently-updated of 23 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Sudden Cardiac Death: what the trials found

Management of sudden cardiac death involves various device interventions. Implantable Cardioverter Defibrillators (ICD) and Cardiac Resynchronization Therapy (CRT-D) have been evaluated; CRT-D demonstrated a defibrillation threshold difference of 5.6 Volts between implant and 6 months 2. For ICD and CRT-D devices, defibrillation thresholds were recorded at 427 for a 3.5 ms waveform, 454 for a 2.5 ms waveform, and 435 for a 4.5 ms waveform 3.

Wearable Cardioverter Defibrillators have been utilized in clinical settings 8. In a study of this device, the percentage of patients achieving LVEF recovery at 90 and 180 days ranged from 0% to 222%, while the percentage of patients reaching target doses of Guideline Directed Medical Therapy (GDMT) varied between 16% and 164%. The incidence of other arrhythmias in this cohort was reported as low as 0% to 1% 7.

Recent results — preliminary, needs further review

  • Pre-arrival instructions for out-of-hospital cardiac arrest did not show a statistically significant difference in the incidence of bystander CPR (p=0.41) 1.
  • ECMO resuscitation was evaluated with clinical outcomes measured via MRS at 3 months, showing limited success 6.

For the clinician treating this condition

  • ICD and CRT-D devices are established interventions with documented defibrillation thresholds across various waveforms [2, 3].
  • Wearable Cardioverter Defibrillators are utilized in clinical practice; however, patient outcomes regarding LVEF recovery and GDMT adherence vary significantly [7, 8].

AI synthesis of 6 cited trials, updated Jun 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Cardiac Arrest

Related studies from across the Cardiac Arrest family.

PEEP Valve in Bag-Valve-Mask CPR for Cardiac Arrest Outcomes
Emergency Medicine RCT
PEEP Valve in Bag-Valve-Mask CPR for Cardiac Arrest Outcomes New trial plans to test airway pressure during cardiac arrest
This protocol outlines a trial testing whether a PEEP valve during bag-valve-mask ventilation improves neurological outcomes in out-of-hospi…
A large new trial will test if using a special valve during CPR helps patients with heart attacks have better neurological outcomes.
Manual pressure augmentation did not improve survival to hospital discharge in shockable OHCA
Emergency Medicine RCT
Manual pressure augmentation did not improve survival to hospital discharge in shockable OHCA Manual pressure during defibrillation does not improve cardiac arrest survival
This cluster-randomized controlled trial of 560 adults with out-of-hospital cardiac arrest and a shockable rhythm found that manual pressure…
A trial involving 560 patients found that adding manual pressure during shocks did not improve survival rates for those in cardiac arrest.
Standard cardiopulmonary resuscitation improves survival rates in patients with out-of-hospital cardiac arrest
Emergency Medicine Meta-analysis
Standard cardiopulmonary resuscitation improves survival rates in patients with out-of-hospital cardiac arrest Standard CPR May Improve Survival After Out-of-Hospital Cardiac Arrest
This meta-analysis compared standard cardiopulmonary resuscitation to chest compression-only techniques for patients experiencing out-of-hos…
New data suggests that standard cardiopulmonary resuscitation may improve survival rates for people experiencing a cardiac arrest outside of…
Frailty is associated with higher mortality and poorer neurological outcomes in patients with cardiac arrest
Emergency Medicine Meta-analysis
Frailty is associated with higher mortality and poorer neurological outcomes in patients with cardiac arrest Frailty Linked to Higher Mortality Risk in Cardiac Arrest Patients
This meta-analysis of 12 studies analyzed the impact of frailty on outcomes for adult patients experiencing cardiac arrest. The analysis fou…
Patients with cardiac arrest who are also identified as frail face significantly higher risks of death and poorer neurological outcomes.
Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients
Cardiology Sys. Review
Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients Palliative care linked to better choices for cardiac arrest patients
This narrative review examines palliative care for patients with cardiac arrest and cardiogenic shock and their caregivers. The authors repo…
A review suggests palliative care helps patients with cardiac arrest make decisions about life-sustaining treatments and lowers healthcare c…
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest
Emergency Medicine RCT
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest New trial shows bone and vein access methods give similar survival rates for heart stop patients
This randomized clinical trial enrolled 1479 adults with non-traumatic out-of-hospital cardiac arrest to compare initial intraosseous vascul…
Doctors compared putting medicine in a bone versus a vein for adults whose hearts stopped outside a hospital. The study found no important d…
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
Emergency Medicine Meta-analysis
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access
Emergency Medicine Meta-analysis
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access Using a bone needle instead of a vein line lowers survival chances for cardiac arrest patients
This systematic review and meta-analysis of 245,132 out-of-hospital cardiac arrest patients found that intraosseous access was associated wi…
A huge study of over 245,000 people found that putting medicine into a bone vein works worse than using a standard arm vein. Doctors should …
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest
Emergency Medicine RCT
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest Hands-free ultrasound speeds up heart restart checks for cardiac arrest patients
This randomized controlled trial of 341 adults with in-hospital cardiac arrest found that hands-free carotid ultrasound (CADFlow) led to a…
A new trial shows hands-free ultrasound devices help medical teams detect heart restart success faster and more accurately during cardiac ar…
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation
Emergency Medicine RCT
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation Timing of heart scans does not change survival odds for older cardiac arrest survivors
This randomized controlled trial in 529 patients with out-of-hospital cardiac arrest compared immediate versus delayed coronary angiography.
New research shows rushing heart scans does not save more lives for older people after cardiac arrest without heart attack signs
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation
Radiology & Imaging RCT
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation Immediate heart scan after arrest shows no long-term survival gain
This randomized trial enrolled 552 patients resuscitated from out-of-hospital cardiac arrest without ST-segment elevation at nineteen Dutch …
Five years after a sudden cardiac arrest, patients who got an immediate heart scan did no better than those who waited, raising questions ab…
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland
Cardiology Meta-analysis
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland Japan's AED System Could Save Lives in Poland
This meta-analysis synthesizes data from Seventeen studies regarding coordinated automated external defibrillator systems for patients with…
A unified national plan for AEDs works far better than scattered devices sitting alone.

Questions about Sudden Cardiac Death

Does having a prior history of atrial fibrillation increase sudden cardiac death risk?

Yes, a prior history of atrial fibrillation is linked to a higher risk of sudden cardiac death, especially in patients with heart attack or heart failure.

Full answer →