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Sudden Cardiac Death

Part of Cardiac Arrest

4 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Sudden Cardiac Death

23 trials tracked for Sudden Cardiac Death: 3 in phase 3 or 4 and 1 with published results. The most-cited published study has 170 citations.

23Trials tracked
3Phase 3 & 4
0Recruiting
1With published results
Phase distribution
Phase 4 2 Phase 3 1 Phase 1 1 Other / NA 19
  1. Phase 3 Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging Completed · 170 cited
  2. Phase 4 'Effect of CRT on Defibrillation Threshold Estimates' Study Completed
  3. Phase 4 POWER (Pulse Width Optimized Waveform Evaluation Trial) Completed
  4. Phase 1 Automatic External Defibrillation Monitoring in Cardiac Arrest Completed
  5. N/A Heart Failure and Sudden Cardiac Death Japan Registry Completed
  6. N/A Extracellular Matrix Marker of Arrhythmia Risk (EMMA) Completed
Show 17 more trials
  1. N/A Same Day Subcutaneous ICD And Send Home (DASH) Completed
  2. N/A Assessment of Primary Prevention Patients Receiving An ICD - Systematic Evaluation of ATP Completed
  3. N/A Educational Videos to Address Racial Disparities in Implantable Cardioverter Defibrillator Therapy Completed
  4. N/A Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest Completed
  5. N/A SJ4 Post Approval Study in Implantable Cardioverter-Defibrillator and Cardiac Resynchronization Therapy Defibrillator Patients Completed
  6. N/A Optimization of VNS in Epileptic Patients to Induce Cardioprotection Completed
  7. N/A Pre-arrival Instructions Effect on Bystander Cardiopulmonary Resuscitation (CPR). Completed
  8. N/A DISCOVERY: Diagnostic Data and Genetic Polymorphisms in ICD Patients. Completed
  9. N/A LifeVest Safety and Efficacy in Real Life Settings in France Completed
  10. N/A Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 ) Completed
  11. N/A Heart Rate Response to Regadenoson and Sudden Cardiac Death Completed
  12. N/A Next Generation INCEPTA Implantable Cardioverter Defibrillator (ICD) and Cardiac Resynchronization Therapy (CRT-D) Field Following Study Completed
  13. N/A Heart Failure Optimization Study Completed
  14. N/A ASSURE WCD Clinical Evaluation - Conversion Efficacy Study Completed
  15. N/A REASSURE AV Registry Completed
  16. N/A SAFEty of Two Strategies of ICD Management at Implantation Completed
  17. N/A ECPR for Refractory Out-Of-Hospital Cardiac Arrest Completed

Showing the 23 most-cited and recently-updated of 23 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.

Research across Cardiac Arrest

Related studies from across the Cardiac Arrest family.

Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients
Cardiology Sys. Review
Palliative care consultation increases do-not-resuscitate orders and decreases healthcare utilization in cardiac arrest and cardiogenic shock patients Palliative care linked to better choices for cardiac arrest patients
This narrative review examines palliative care for patients with cardiac arrest and cardiogenic shock and their caregivers. The authors repo…
A review suggests palliative care helps patients with cardiac arrest make decisions about life-sustaining treatments and lowers healthcare c…
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest
Emergency Medicine RCT
Initial intraosseous access shows no survival benefit over intravenous access in out-of-hospital cardiac arrest New trial shows bone and vein access methods give similar survival rates for heart stop patients
This randomized clinical trial enrolled 1479 adults with non-traumatic out-of-hospital cardiac arrest to compare initial intraosseous vascul…
Doctors compared putting medicine in a bone versus a vein for adults whose hearts stopped outside a hospital. The study found no important d…
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest
Emergency Medicine Meta-analysis
Immunomodulatory therapies showed no mortality benefit or neurological harm in 2605 adults after cardiac arrest New drug review shows no benefit for heart attack survivors
This systematic review and meta-analysis evaluated immunomodulatory therapeutics in adults following in- and out-of-hospital cardiac arrest.…
A large review of immune drugs found no clear benefit for heart attack survivors and did not lower death rates within 30 days.
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access
Emergency Medicine Meta-analysis
Intraosseous route for out-of-hospital cardiac arrest linked to lower outcomes than intravenous access Using a bone needle instead of a vein line lowers survival chances for cardiac arrest patients
This systematic review and meta-analysis of 245,132 out-of-hospital cardiac arrest patients found that intraosseous access was associated wi…
A huge study of over 245,000 people found that putting medicine into a bone vein works worse than using a standard arm vein. Doctors should …
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest
Emergency Medicine RCT
Hands-free carotid ultrasound improves ROSC detection in cardiac arrest Hands-free ultrasound speeds up heart restart checks for cardiac arrest patients
This randomized controlled trial of 341 adults with in-hospital cardiac arrest found that hands-free carotid ultrasound (CADFlow) led to a…
A new trial shows hands-free ultrasound devices help medical teams detect heart restart success faster and more accurately during cardiac ar…
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation
Emergency Medicine RCT
Immediate coronary angiography does not alter 30-day mortality in OHCA survivors without ST elevation Timing of heart scans does not change survival odds for older cardiac arrest survivors
This randomized controlled trial in 529 patients with out-of-hospital cardiac arrest compared immediate versus delayed coronary angiography.
New research shows rushing heart scans does not save more lives for older people after cardiac arrest without heart attack signs
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation
Radiology & Imaging RCT
Immediate coronary angiography showed no 5-year survival benefit versus delayed angiography in OHCA patients without ST elevation Immediate heart scan after arrest shows no long-term survival gain
This randomized trial enrolled 552 patients resuscitated from out-of-hospital cardiac arrest without ST-segment elevation at nineteen Dutch …
Five years after a sudden cardiac arrest, patients who got an immediate heart scan did no better than those who waited, raising questions ab…
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland
Cardiology Meta-analysis
Meta-analysis of coordinated AED systems for out-of-hospital cardiac arrest in Japan and Poland Japan's AED System Could Save Lives in Poland
This meta-analysis synthesizes data from Seventeen studies regarding coordinated automated external defibrillator systems for patients with…
A unified national plan for AEDs works far better than scattered devices sitting alone.
Plasma proteins linked to HCM severity identified in MYBPC3 carriers and UK Biobank
Cardiology
Plasma proteins linked to HCM severity identified in MYBPC3 carriers and UK Biobank Could blood proteins predict dangerous heart conditions like sudden cardiac arrest in people with specific gene mutations?
This observational study examined 144 MYBPC3 pathogenic variant carriers and 6,492 UK Biobank participants to identify plasma proteins assoc…
Blood proteins linked to heart failure and sudden cardiac arrest appear in people with specific gene mutations, offering new warning signs f…
Video call-assisted dispatcher guidance improves CPR quality metrics in simulation study of untrained students
Emergency Medicine RCT
Video call-assisted dispatcher guidance improves CPR quality metrics in simulation study of untrained students Can a video call help someone save a life when they've never learned CPR?
A randomized, single-blind, manikin-based trial with 85 university students without prior CPR training found video call-assisted dispatcher …
A video call where a dispatcher demonstrates CPR on a manikin helped untrained students perform deeper compressions with fewer pauses than a…
Video laryngoscopes improve success rates and reduce dental compression compared with direct laryngoscopes in pediatric cardiac arrest simulations
Emergency Medicine Meta-analysis
Video laryngoscopes improve success rates and reduce dental compression compared with direct laryngoscopes in pediatric cardiac arrest simulations When saving a child's life, does the camera on the tube make a difference?
This systematic review and meta-analysis evaluated 13 simulation-based studies involving 2,080 intubation attempts on pediatric manikins.
In simulated emergencies, tools with cameras helped doctors place breathing tubes faster and more often than older tools.
Supraglottic airway versus endotracheal intubation shows no overall survival benefit in out-of-hospital cardiac arrest
Emergency Medicine Meta-analysis
Supraglottic airway versus endotracheal intubation shows no overall survival benefit in out-of-hospital cardiac arrest Study finds airway device choice doesn't change survival after cardiac arrest outside hospitals
A systematic review and meta-analysis of 14,797 patients with out-of-hospital cardiac arrest found no significant difference in return of sp…
Paramedics saving people whose hearts stop outside hospitals find no survival benefit from complex breathing tubes versus simpler airway dev…

Questions about Sudden Cardiac Death

Does having a prior history of atrial fibrillation increase sudden cardiac death risk?

Yes, a prior history of atrial fibrillation is linked to a higher risk of sudden cardiac death, especially in patients with heart attack or heart failure.

Full answer →