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Home › Medications › testosterone

testosterone

5 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials of testosterone

27 trials tracked of testosterone: 13 in phase 3 or 4 and 7 with published results. The most-cited published study has 278 citations.

27Trials tracked
13Phase 3 & 4
0Recruiting
7With published results
Phase distribution
Phase 4 5 Phase 3 8 Phase 2 3 Phase 1 6 Other / NA 5
  1. Phase 4 Testosterone Replacement in Men With Diabetes and Obesity Completed · 278 cited
  2. Phase 3 Safety and Efficacy of Intranasal TBS-1 Treatment of Male Hypogonadism Completed · 81 cited
  3. Phase 3 Starting a Testosterone and Exercise Program After Hip Injury Completed · 73 cited
  4. Phase 3 Testosterone Administration and ACL Reconstruction in Men Completed · 24 cited
  5. Phase 3 Lifestyle Intervention and Testosterone Replacement in Obese Seniors Completed · 16 cited
  6. Phase 3 Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment Completed · 14 cited
Show 21 more trials
  1. Phase 4 Influence of Testosterone Administration on Drug-Induced QT Interval Prolongation and Torsades de Pointes Completed · 7 cited
  2. Phase 4 Intranasal Delivery of Testosterone and Its Effect on Doping Markers Completed
  3. Phase 4 Subcutaneous vs. Intramuscular Testosterone Completed
  4. Phase 4 Testosterone for Peripheral Vascular Disease Completed
  5. Phase 3 Testosterone Replacement for Fatigue in Male Hypogonadic Advanced Cancer Patients Completed
  6. Phase 3 A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone Completed
  7. Phase 3 Bone Loss in Women With Anorexia Nervosa Completed
  8. Phase 2 Hormonal Factors in the Treatment of Anorexia Nervosa Completed
  9. Phase 2 The Effect on Androxal Versus Androgel on Morning Testosterone in Men With Secondary Hypogonadism (Low Testosterone) Completed
  10. Phase 2 Testosterone and Growth Hormone for Bone Loss in Men Completed
  11. Phase 1 The Influence of Testosterone on Experimental Pain Perception Completed
  12. Phase 1 Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: The Effects of Vaginal Testosterone Therapy Completed
  13. Phase 1 Cycled Testosterone Replacement Study Completed
  14. Phase 1 ORAL T-6: Oral Androgens in Man-6 Completed
  15. Phase 1 A Study of Effect of Deodorant and Axillary Hair on Testosterone Absorption in Healthy Participants Completed
  16. Phase 1 Study of the Safety, and Sperm and Gonadotropin Suppression of a Contraceptive Gel in Normal Men Completed
  17. N/A Testosterone Antidepressant Augmentation in Women Completed
  18. N/A Effects of Testosterone in Women With Depression Completed
  19. N/A Sex Steroids, Sleep, and Metabolic Dysfunction in Women Completed
  20. N/A Metabolic Effects of Androgenicity in Aging Men and Women Completed
  21. N/A Dose-Response of Gonadal Steroids and Bone Turnover in Older Men Completed

Showing the 27 most-cited and recently-updated of 27 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Meta-analysis shows testosterone replacement therapy increases clinical fracture risk in hypogonadal men compared to placebo
Orthopedics & Sports Medicine Meta-analysis
Meta-analysis shows testosterone replacement therapy increases clinical fracture risk in hypogonadal men compared to placebo Testosterone therapy raises fracture risk in hypogonadal men
A systematic review of 2,711 hypogonadal men found that testosterone replacement therapy significantly increased the risk of clinical fractu…
A large review found that men with low testosterone taking replacement therapy had a higher risk of clinical fractures compared to those on …
Jun 5, 2026
Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone
Oncology RCT
Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone Adding chemo to hormone therapy for prostate cancer may depend on testosterone levels
This RCT subgroup analysis found that adding docetaxel to radiation and ADT significantly reduced all-cause mortality in nonmetastatic high-…
Adding chemo to standard therapy for high-risk prostate cancer may only help men with normal testosterone levels, a long-term study suggests…
Jun 2, 2026
Systematic review evaluates saliva, DBS, and urine testosterone testing versus serum monitoring during transdermal TRT
OB/GYN & Women's Health Sys. Review
Systematic review evaluates saliva, DBS, and urine testosterone testing versus serum monitoring during transdermal TRT Stop guessing your testosterone levels
This systematic review examined the accuracy of alternative testosterone assays compared to serum testing in patients receiving transdermal …
Saliva tests often show perfect results while you still feel terrible because gels create a false picture of your health that blood tests re…
Frontiers Apr 10, 2026
GAHT in transgender men shows no significant BMD changes but increases muscle strength and body composition
Diabetes & Endocrinology Meta-analysis
GAHT in transgender men shows no significant BMD changes but increases muscle strength and body composition Does hormone therapy affect bone health and strength for transgender men?
A systematic review with meta-analysis of transgender men found gender affirming hormone treatment was not associated with significant longi…
After four years of gender-affirming hormone therapy, transgender men show no bone loss at key sites while gaining muscle strength and lean …
medRxiv Apr 8, 2026
Triple therapy for CHH shows lower hCG dose but similar spermatogenesis rates in small RCT
Diabetes & Endocrinology RCT
Triple therapy for CHH shows lower hCG dose but similar spermatogenesis rates in small RCT Can a triple-hormone approach help men with a rare fertility condition?
A randomized trial in 45 adult males with congenital hypogonadotropic hypogonadism compared triple therapy (hCG, FSH, testosterone) to combi…
Men with a rare fertility condition using three hormones together needed lower weekly doses of one drug and reported better quality of life …
Frontiers Apr 8, 2026