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Universal digital mental health interventions show significant overall effects for anxiety and depression in children and adolescents

Universal digital mental health interventions show significant overall effects for anxiety and…
Photo by National Cancer Institute / Unsplash
Key Takeaway
Consider universal DMHIs for youth mental health; effects significant at 6 months.

This meta-analysis evaluated universal digital mental health interventions (DMHIs) for children and adolescents aged 19 or younger within the general population. The analysis included 29 studies and assessed outcomes such as anxiety, depression, psychological distress, externalising problems, psychological well-being, interpersonal functioning, and social-emotional skills.

Significant overall effects were found with an effect size of 0.16. Specific outcomes showed significant effects with effect sizes of 0.09 for anxiety, 0.06 for depression, 0.28 for psychological distress, 0.21 for externalising problems, 0.19 for psychological well-being, 0.21 for interpersonal functioning, and 0.19 for social-emotional skills. At follow-up of 6.0 months or longer, significant overall effects persisted with an effect size of 0.09. Anxiety and depression effects at follow-up were 0.11 and 0.05 respectively.

Safety data including adverse events, serious adverse events, discontinuations, and tolerability were not reported. The authors highlight a scarcity of meta-analyses examining short- and long-term effects or potential moderators in individuals aged 19 or younger. Providing universal DMHIs with longer durations to younger children may be critical for effectively improving a range of mental health outcomes. Future studies may explore how gamification and other features for reducing attrition could be effectively incorporated into DMHIs to promote engagement and effectiveness.

Study Details

Study typeMeta analysis
EvidenceLevel 1
Follow-up6.0 mo
PublishedJun 2026
View Original Abstract ↓
IntroductionUniversal digital mental health interventions (DMHIs) are emerging as a viable approach to promoting mental health among children and adolescents in general population. However, there is a scarcity of meta-analyses that examined their short- and long-term effects or potential moderators in individuals aged 19 or younger.MethodsA systematic search was conducted to identify randomised controlled trials that delivered universal DMHIs for promoting mental health, targeting children and adolescents aged 19 or younger in general population. Meta-analysis was performed to identify studies using Comprehensive Meta-Analysis.ResultsThe meta-analysis of 29 included studies identified significant overall effects ( = 0.16) as well as significant effects for anxiety ( = 0.09), depression ( = 0.06), psychological distress ( = 0.28), externalising problem ( = 0.21), psychological well-being ( = 0.19), interpersonal functioning ( = 0.21) and social-emotional skills ( = 0.19) at post-intervention. The analysis of 7 studies that followed up 6 months or longer revealed a significant overall effect ( = 0.09) as well as significant effects for anxiety ( = 0.11) and depression ( = 0.05) at follow-up. Age and intervention duration moderated the overall effects. Gamification moderated the effect on depression. Attrition rate moderated the effect on social-emotional skills.ConclusionsProviding universal DMHIs with longer durations to younger children may be critical for effectively improving a range of mental health outcomes among children and adolescents. To promote engagement and effectiveness, future studies may explore how gamification and other features for reducing attrition could be effectively incorporated into DMHIs.
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