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Home › Conditions › Psychological distress

Psychological distress

8 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Psychological distress

22 trials tracked for Psychological distress.

22Trials tracked
0Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 2 1 Phase 1 2 Other / NA 19
  1. Phase 2 Diabetes Homeless Medication Support Completed
  2. Phase 1 A Family-based, Resilience-focused Intervention for War-affected Communities in North-eastern Democratic Republic of Congo Completed
  3. Phase 1 Healthy Minds Program App Dosage Completed
  4. N/A A Needs-focused Palliative Care Intervention for Older Adults in ICUs Completed
  5. N/A Shift-and-persist and Cardiometabolic Markers Among Women in Puerto Rico Completed
  6. N/A Examine the Effects of Meditation on Daily Psychological Stress Responses in Woman With a History of Child Adversity Completed
Show 16 more trials
  1. N/A Facilitating Assessment of At-Risk Sailors Using Technology Completed
  2. N/A Adapting a Low-cost Intimate Partner Violence and Mental Health Response Intervention Completed
  3. N/A Personalized Feedback for Distress Intolerant Smokers Completed
  4. N/A Acceptance and Commitment Therapy for Older Adults Completed
  5. N/A Behavior, Biology and Well-Being Study Completed
  6. N/A Researching Resiliency in Stressful Experiences (RISE) Program for Men Leaving Incarceration Completed
  7. N/A COVID-19 and the Healthy Minds Program for Educators Completed
  8. N/A Mobile Mindfulness to Improve Psychological Distress After Critical Illness Completed
  9. N/A Symptom Management for YA Cancer Survivors Completed
  10. N/A Effects of Biofeedback in Patients With Acute Cerebral Infarction Completed
  11. N/A Behavior, Biology and Well-Being Study Completed
  12. N/A Addressing Palliative Care Needs Among Intensive Care Unit Family Members Completed
  13. N/A tAVNS for Stress Reduction in University Students Completed
  14. N/A Effects of Acupressure on Nurses' Psychological Distress, Depression, Job Stress, Occupational Burnout, and Resilience Completed
  15. N/A Can Massage During One Year Improve Health in Health-care Providers Working in Hospital Completed
  16. N/A Messy Memories: Mobile Application Therapy Following Critical Illness Completed

Showing the 22 most-cited and recently-updated of 22 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Smartphone app reduces psychological distress at 3 months with Cohen d -0.17
Primary Care & Family Medicine RCT
Smartphone app reduces psychological distress at 3 months with Cohen d -0.17 Smartphone app reduces workplace stress for some workers in Japan
This randomized controlled trial of 793 workers in Japan found that a stand-alone smartphone app significantly reduced psychological distres…
A smartphone app helped reduce psychological distress in Japanese workers over three months, though the benefits were not sustained long-ter…
Aug 17, 2026
Functional and emotion-focused coping strategies are associated with lower distress in family carers
Psychiatry Meta-analysis
Functional and emotion-focused coping strategies are associated with lower distress in family carers Coping styles impact mental health for parents of children with disabilities
This meta-analysis of 4548 participants examined the relationship between various coping strategies and psychological distress in family car…
Caregivers of dependent children face high stress, but research shows that specific ways of handling daily challenges can lower anxiety and …
Aug 1, 2026
Universal digital mental health interventions show significant overall effects for anxiety and depression in children and adolescents
Primary Care & Family Medicine Meta-analysis
Universal digital mental health interventions show significant overall effects for anxiety and depression in children and adolescents Universal digital mental health tools show benefits for youth anxiety and depression
This meta-analysis examined 29 studies involving children and adolescents aged 19 or younger in the general population. Universal digital me…
A meta-analysis of 29 studies found universal digital mental health interventions significantly improved anxiety, depression, and well-being…
Jun 3, 2026
Rapid review and meta-analysis of psychological distress in adults undergoing Mohs micrographic surgery
Dermatology Meta-analysis
Rapid review and meta-analysis of psychological distress in adults undergoing Mohs micrographic surgery Mohs Surgery Linked To Psychological Distress In Adults
This rapid review and meta-analysis examined psychological adverse events in adults undergoing Mohs micrographic surgery.
A rapid review found psychological distress is common after Mohs surgery, with risks often missing from consent forms.
May 1, 2026
Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients
Oncology RCT
Mirtazapine and olanzapine reduce anxiety and depression scores in oral cavity cancer patients Two Common Pills Ease Cancer Anxiety and Depression
This randomized controlled trial included 144 patients with oral cavity cancer.
Two well-known antidepressants significantly eased anxiety and depression in oral cancer patients, with mirtazapine showing a slight edge.
Apr 29, 2026
Scoping review of mental health in sub-Saharan African university students during COVID-19
Primary Care & Family Medicine Sys. Review
Scoping review of mental health in sub-Saharan African university students during COVID-19 Mental health crisis among African university students revealed
This systematic scoping review synthesized evidence on mental health among university students in sub-Saharan Africa during the COVID-19 pan…
Depression, anxiety, and suicidality are common among university students in sub-Saharan Africa, but help-seeking is rare. A new review maps…
Frontiers Apr 23, 2026
Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months
Psychiatry RCT
Omega-3 supplementation reduces stress, anxiety, and depression in Saudi adults over three months Omega-3s Help Calm Stress And Improve Sleep
A randomized, double-blind, placebo-controlled trial in 64 Saudi adults found that omega-3 supplementation (500 mg EPA + 250 mg DHA) signifi…
A new trial shows omega-3 supplements significantly reduce stress, anxiety, and depression while improving sleep and memory in people with s…
Apr 15, 2026
Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV
Nephrology Meta-analysis
Mental health syndemics reduce ART adherence and impair viral suppression in people living with HIV When HIV and Depression Collide, Treatment Suffers
This systematic review and meta-analysis of 32 studies involving people living with HIV (PLWH) examined the impact of mental health-related …
When depression, trauma, and poverty pile onto HIV, people struggle more to take their meds and keep the virus in check.
Frontiers Apr 13, 2026

Questions about Psychological distress

How does mental health syndemics impact ART adherence and viral suppression in people with HIV?

Mental health syndemics, which combine HIV with social and economic stressors, significantly lower antiretroviral therapy adherence and reduce viral suppression in people living with HIV.

Full answer →
How did the COVID-19 pandemic affect psychological distress among sub-Saharan African university students?

The COVID-19 pandemic increased psychological distress among university students in sub-Saharan Africa, driven by isolation, economic hardship, and academic stress.

Full answer →