Clinical Trial Search

Primary: Changes From Baseline in Working Memory Domain Z-score — -0.21955; -0.15432; -0.08842; 0.29594 z-score

Primary: Number of Participants With a Diagnosis of a Cognitive Impairment Disorder Measured by Pharmacological Interventions for the Management of Cognitive Impairment. — 0; 0…

Primary: FCI Score at Follow-up — 147.3; 164.0; 123.3; 150.8 points awarded for correct items

Primary: Face-name Memory Test Performance — -.28; -.01; -1.29; -1.76 pairs correctly recalled/recognized

Primary: N-acetylaspartate — 1.35; 1.86; 1.58; 1.26 NAA/creatine Ratio

Primary: Change From Baseline in Rey Auditory Verbal Learning Test — 1.53; 1.00; 5.30; 4.02 number of words correctly recalled

Primary: Number of MCI/SCD (Mild Cognitive Impairment/Subjective Cognitive Decline) Participants Recruited Within the First Six Months — 35 Participants

Primary: Change in the Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) — -0.89; 0.55 score

Primary: ADAS-Cog-Exec Global Composite — -0.146; -0.068 Change score — p=0.29

Primary: Physical Function — -4.7 score on a scale

Primary: Sleep Latency — 28.51; 47.06 minutes

Primary: Cognitive Measures - Hopkins Verbal Learning Test (HVLT) Total Recall Score — 26.02; 25.76; 27.96; 28.81 units on a scale

Primary: Selective Reminding Test (SRT) Total Recall — 45.6; 46.6 Words

Primary: Client Satisfaction Questionnaire 3-Item (CSQ-3): Number of Participants With Scores Above and Below Scale Midpoint — 8; 9; 0; 1 Participants

Primary: Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment — 80.0; 62.45 percent correct — p=<.001

Primary: fMRI Measure of Hippocampal Activation — 36.4; 41.3 percentage of active voxels

Primary: Change From Baseline in California Verbal Learning Task Score — 3.04; 5.17; 4.22; 7.04 score on a scale

Primary: Change in Score on the Rey Auditory Verbal Learning Test (RAVLT) — 13.8; 17.8; 18.0; 13.4 T-score on a scale — p=0.25

Primary: Episodic Memory Improvement — 31.8; 31.3 score on a scale — p=0.531

Primary: Change in East Boston Memory Test Scores From Baseline to 24 Weeks, 48 Weeks, and 72 Weeks — 0.03; -0.02; 0.01; 0.05 score on a scale — p=.409

Primary: Influence of the Neuroimaging Test on a Finding of Alzheimer's Disease as the Underlying Cause of the Mild Memory Loss — 3; 12; 9; 31 participants

Primary: Improvement of Cognitive Performance (Change From Baseline in Neuropsychological Computerized Test) — 3.46; 13.19; 7.92; 9.19 Points on a scale

Primary: Change in Total Recall Score in the Selective Reminding Test — 5.7; 9.4 score on a scale — p=0.05

Primary: Change in Plasma Amyloid Beta (Aβ) Levels — 0.343; -0.371; 0.381; -0.332 Z-score — p=0.817

Primary: Daily Steps Change From Baseline to Month 2 — 604.1 steps per day — p=0.376

Primary: The Effect of Niagen vs PBO on Cognition as Measured by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). — 92.15; 91.04; 94.87; 95.17…

Primary: Number of Participants With a Decline of 6 Points on the Hopkins Verbal Learning Test-Revised (HVLT-R) — 1; 9 Participants — p=.02

Primary: Memory Function — 25.5; 24.0; 9.7; 9.0 score on a scale

Primary: Arterial Compliance (m^2 Kilopascal^-1) — 0.824; 0.772 m^2 kilopascal^-1

Primary: Change in Plasma Amyloid Beta (Aβ) Levels — -0.38; 0.02; 0.24; -0.08 Z-score — p=0.003